Results 71 to 80 of about 1,493,002 (262)

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Targeted Genetic Screen in Amyotrophic Lateral Sclerosis Reveals Novel Genetic Variants with Synergistic Effect on Clinical Phenotype [PDF]

, 2017
Amyotrophic lateral sclerosis (ALS) is underpinned by an oligogenic rare variant architecture. Identified genetic variants of ALS include RNA-binding proteins containing prion-like domains (PrLDs). We hypothesized that screening genes encoding additional
Adrian Higginbottom, Adriano Chio, Ahmad Al Kheifat, Alberto Garcia Redondo, Aleksey Shatunov, Alfredo Iacoangeli, Ammar Al-Chalabi, Annelot Dekker, Bas Middelkoop, Chris Shaw, Christopher J. McDermott, Gijs Tazelaar, Guillaume M. Hautbergue, Henry Robins, Ian Blair, Isabell Niedermoser, Jan Veldink, Janine Kirby, Jesus Mora Pardina, John Landers, Johnathan Cooper-Knock, Joke van Vugt, Jonathan Glass, Jonathan Mill, Karen Morrison, Kevin Kenna, Kristelvan Eijk, Leonard van den Berg, Maarten Kooyman, Mamede de Carvalho, Marc Gotkine, Markus Weber, Matthew Kiernan, Matthew Wyles, Mattieu Moisse, Mayana Ztaz, Mbombe Kazoka, Michael van Es, Miguel Mitne Neto, Nazli Basak, Nicola Ticozzi, Orla Hardiman, Pamela J. Shaw, Paul G. Ince, Paul R. Heath, Peter Andersen, Philip van Damme, Philippe Corcia, Philippe Couratier, Project MinE ALS Sequencing Consortium, Rick van der Spek, Russel McLaughlin, Sara Pulit, Stephen Newhouse, Susana Pinto, Theresa Walsh, Vincenzo Silani, Vivian Drory, William Sproviero, Wim Robberecht, Winston Hide, Wouter van Rheenen   +61 more
core   +5 more sources

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

FEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche, John R. Riordan, Burkhard Tümmler   +2 more
wiley   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Interplay between single-stranded binding proteins on RNA secondary structure

, 2013
RNA protein interactions control the fate of cellular RNAs and play an important role in gene regulation. An interdependency between such interactions allows for the implementation of logic functions in gene regulation.
Bundschuh, Ralf, Lin, Yi-Hsuan
core   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

Inference of RNA decay rate from transcriptional profiling highlights the regulatory programs of Alzheimer's disease. [PDF]

, 2017
The abundance of mRNA is mainly determined by the rates of RNA transcription and decay. Here, we present a method for unbiased estimation of differential mRNA decay rate from RNA-sequencing data by modeling the kinetics of mRNA metabolism.
Alkallas, Rached, Fish, Lisa, Goodarzi, Hani, Najafabadi, Hamed S   +3 more
core   +3 more sources

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Predicting sequence and structural specificities of RNA binding regions recognized by splicing factor SRSF1 [PDF]

, 2011
- RNA-binding proteins (RBPs) play diverse roles in eukaryotic RNA processing. Despite their pervasive functions in coding and non-coding RNA biogenesis and regulation, elucidating the specificities that define protein-RNA interactions remains a major ...
Juan, Liran, Liu, Yunlong, Lv, Junjie, Sanford, Jeremy R, Wang, Kejun, Wang, Xin   +5 more
core   +3 more sources

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source