Results 71 to 80 of about 2,765,005 (400)

RNA-binding proteins in Mendelian disease

Trends in Genetics, 2013
RNA-binding proteins (RBPs) control all aspects of RNA fate, and defects in their function underlie a broad spectrum of human pathologies. We focus here on two recent studies that uncovered the in vivo mRNA interactomes of human cells, jointly implicating over 1100 proteins in RNA binding.
Castello, Alfredo, Fischer, Bernd, Hentze, Matthias, Preiss, Thomas   +3 more
openaire   +4 more sources

Functional Advantages of Conserved Intrinsic Disorder in RNA-Binding Proteins. [PDF]

PLoS ONE, 2015
Proteins form large macromolecular assemblies with RNA that govern essential molecular processes. RNA-binding proteins have often been associated with conformational flexibility, yet the extent and functional implications of their intrinsic disorder have
Mihaly Varadi, Fruzsina Zsolyomi, Mainak Guharoy, Peter Tompa   +3 more
doaj   +1 more source

Comprehensive landscape of the functions and prognostic value of RNA binding proteins in uterine corpus endometrial carcinoma

Frontiers in Molecular Biosciences, 2022
Background: The dysregulation of RNA binding proteins (RBPs) is involved in tumorigenesis and progression. However, information on the overall function of RNA binding proteins in Uterine Corpus Endometrial Carcinoma (UCEC) remains to be studied.
Yong Yao, Yong Yao, Yong Yao, Kangping Liu, Kangping Liu, Kangping Liu, Yuxuan Wu, Yuxuan Wu, Yuxuan Wu, Jieyu Zhou, Jieyu Zhou, Jieyu Zhou, Heyue Jin, Heyue Jin, Heyue Jin, Yimin Zhang, Yimin Zhang, Yimin Zhang, Yumin Zhu, Yumin Zhu, Yumin Zhu   +20 more
doaj   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Filling a GAP(DH) in Asymmetric Viral RNA Synthesis [PDF]

, 2008
SummaryHost proteins, such as RNA-binding proteins, are involved in most steps of replication by positive-strand RNA viruses, including Tomato bushy stunt virus (TBSV). In this issue of Cell Host & Microbe, Wang and Nagy report that efficient replication
Ahlquist, Paul, Wang, Xiaofeng
core   +1 more source

Sequence, Structure and Context Preferences of Human RNA Binding Proteins

bioRxiv, 2017
Production of functional cellular RNAs involves multiple processing and regulatory steps principally mediated by RNA binding proteins (RBPs). Here we present the affinity landscapes of 78 human RBPs using an unbiased assay that determines the sequence ...
Daniel Dominguez, Peter Freese, M. Alexis, Amanda Su, Myles Hochman, T. Palden, C. Bazile, Nicole J. Lambert, Eric L. Van Nostrand, G. Pratt, Gene W. Yeo, B. Graveley, C. Burge   +12 more
semanticscholar   +1 more source

RNA‐binding proteins in diabetic microangiopathy

Journal of Clinical Laboratory Analysis, 2022
AbstractBackgroundAs the most common complication of diabetes, the diabetic microangiopathy characterizes diabetic retinopathy (DR) and nephropathy (DN). Diabetic microangiopathy has always been a serious clinical problem. A wide variety of nucleic acid interacting factors called the RNA binding proteins (RBPS) take part in several crucial cellular ...
Chao Tu, Liangzhi Wang, Lan Wei
openaire   +2 more sources

Finding RNA structure in the unstructured RBPome

BMC Genomics, 2018
Background RNA-binding proteins (RBPs) play vital roles in many processes in the cell. Different RBPs bind RNA with different sequence and structure specificities.
Yaron Orenstein, Uwe Ohler, Bonnie Berger   +2 more
doaj   +1 more source

Transcriptome-Wide Identification of Coding and Noncoding RNA-Binding Proteins Defines the Comprehensive RNA Interactome of Leishmania mexicana

Microbiology Spectrum, 2022
Proteomic profiling of RNA-binding proteins in Leishmania is currently limited to polyadenylated mRNA-binding proteins, leaving proteins that interact with nonadenylated RNAs, including noncoding RNAs and pre-mRNAs, unidentified.
Karunakaran Kalesh, Wenbin Wei, Brian S. Mantilla, Theodoros I. Roumeliotis, Jyoti Choudhary, Paul W. Denny   +5 more
doaj   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source