Results 51 to 60 of about 2,650,407 (299)
An in Vitro Technique to Identify the RNA Binding-Site Sequences for RNA-Binding Proteins [PDF]
BioTechniques, 2017 RNA-protein interactions play a major role in gene regulation. Although many techniques to analyze RNA-protein interactions have been developed, noteworthy challenges such as determining the RNA sequences that bind RNA-binding proteins (RBPs) remain unsolved.
SunKyung Choi +3 more
openaire +3 more sources
Characterization of a novel association between two trypanosome-specific proteins and 5S rRNA. [PDF]
PLoS ONE, 2012 P34 and P37 are two previously identified RNA binding proteins in the flagellate protozoan Trypanosoma brucei. RNA interference studies have determined that the proteins are essential and are involved in ribosome biogenesis.
Martin Ciganda, Noreen Williams
doaj +1 more source
RNA-Binding Proteins Hold Key Roles in Function, Dysfunction, and Disease
Biology, 2021 Simple Summary Chronic hyperglycemia manifests in a variety of different micro- and macrovascular disorders such as diabetes mellitus and cardiovascular disease and has been shown to have links to post-transcriptional dysregulation.
Sophia Kelaini +3 more
semanticscholar +1 more source
Single molecule probing of disordered RNA binding proteins
STAR Protocols, 2022 Summary: Liquid-liquid phase separation of intrinsically disordered proteins is known to underlie diverse pathologies such as neurodegeneration, cancer, and aging.
Kevin Rhine, Sua Myong
doaj +1 more source
PLoS Biology, 2004 Genes encoding RNA-binding proteins are diverse and abundant in eukaryotic genomes. Although some have been shown to have roles in post-transcriptional regulation of the expression of specific genes, few of these proteins have been studied systematically.
André P. Gerber, D. Herschlag, P. Brown
semanticscholar +1 more source
Beyond RNA-binding domains: determinants of protein–RNA binding
RNARNA-binding proteins (RBPs) are composed of RNA-binding domains (RBDs) often linked via intrinsically disordered regions (IDRs). Structural and biochemical analyses have shown that disordered linkers contribute to RNA binding by orienting the adjacent RBDs and also characterized certain disordered repeats that directly contact the RNA.
Zigdon, Inbal +5 more
openaire +2 more sources
Alternative polyadenylation and RNA-binding proteins [PDF]
Journal of Molecular Endocrinology, 2016 Our understanding of the extent of microRNA-based gene regulation has expanded in an impressive pace over the past decade. Now, we are beginning to better appreciate the role of 3′-UTR (untranslated region) cis-elements which harbor not only microRNA but also RNA-binding protein (RBP) binding sites that have significant effect on the stability and ...
openaire +3 more sources
The regulatory impact of RNA-binding proteins on microRNA targeting
Nature Communications, 2021 Argonaute is the primary mediator of metazoan miRNA targeting (MT). Among the currently identified >1,500 human RNA-binding proteins (RBPs), there are only a handful of RBPs known to enhance MT and several others reported to suppress MT, leaving the ...
Sukjun Kim +14 more
semanticscholar +1 more source
Nature CommunicationsADP-ribosylation has long been recognised as a key regulator of essential signalling pathways, including the DNA damage response. However, only recent and ongoing technological advances are beginning to make it possible to investigate its distinct forms ...
Helen Dauben +6 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Neurotoxicity is a rare, often dose‐limiting adverse effect of methotrexate (MTX) therapy that disproportionally affects Latino children. Factors contributing to the observed disparity are not well understood. This study leveraged admixture mapping to identify genetic regions associated with MTX‐related neurotoxicity susceptibility ...
Rachel D. Harris +24 more
wiley +1 more source