Results 71 to 80 of about 2,650,407 (299)

Comprehensive landscape of the functions and prognostic value of RNA binding proteins in uterine corpus endometrial carcinoma

Frontiers in Molecular Biosciences, 2022
Background: The dysregulation of RNA binding proteins (RBPs) is involved in tumorigenesis and progression. However, information on the overall function of RNA binding proteins in Uterine Corpus Endometrial Carcinoma (UCEC) remains to be studied.
Yong Yao, Yong Yao, Yong Yao, Kangping Liu, Kangping Liu, Kangping Liu, Yuxuan Wu, Yuxuan Wu, Yuxuan Wu, Jieyu Zhou, Jieyu Zhou, Jieyu Zhou, Heyue Jin, Heyue Jin, Heyue Jin, Yimin Zhang, Yimin Zhang, Yimin Zhang, Yumin Zhu, Yumin Zhu, Yumin Zhu   +20 more
doaj   +1 more source

RNA‐PROTACs: Degraders of RNA‐Binding Proteins

Angewandte Chemie, 2020
Defects in the functions of RNA binding proteins (RBPs) are at the origin of many diseases; however, targeting RBPs with conventional drugs has proven difficult.
A. Ghidini, A. Cléry, François Halloy, F. Allain, Jonathan Hall   +4 more
semanticscholar   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

RNA-Binding Proteins in Plant Immunity [PDF]

Journal of Pathogens, 2011
Plant defence responses against pathogen infection are crucial to plant survival. The high degree of regulation of plant immunity occurs both transcriptionally and posttranscriptionally. Once transcribed, target gene RNA must be processed prior to translation. This includes polyadenylation,5′capping, editing, splicing, and mRNA export.
Woloshen, Virginia, Huang, Shuai, Li, Xin   +2 more
openaire   +2 more sources

Finding RNA structure in the unstructured RBPome

BMC Genomics, 2018
Background RNA-binding proteins (RBPs) play vital roles in many processes in the cell. Different RBPs bind RNA with different sequence and structure specificities.
Yaron Orenstein, Uwe Ohler, Bonnie Berger   +2 more
doaj   +1 more source

Transcriptome-Wide Identification of Coding and Noncoding RNA-Binding Proteins Defines the Comprehensive RNA Interactome of Leishmania mexicana

Microbiology Spectrum, 2022
Proteomic profiling of RNA-binding proteins in Leishmania is currently limited to polyadenylated mRNA-binding proteins, leaving proteins that interact with nonadenylated RNAs, including noncoding RNAs and pre-mRNAs, unidentified.
Karunakaran Kalesh, Wenbin Wei, Brian S. Mantilla, Theodoros I. Roumeliotis, Jyoti Choudhary, Paul W. Denny   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Identification of Protein-RNA Interactions in Mouse Testis Tissue Using fRIP

Bio-Protocol, 2022
During development, cells must quickly switch from one cell state to the next to execute precise and timely differentiation. One method to ensure fast transitions in cell states is by controlling gene expression at the post-transcriptional level through ...
Alexis Bailey, Pedro Batista, Howard Chang, Margaret Fuller   +3 more
doaj   +1 more source

Alternative splicing and related RNA binding proteins in human health and disease

Signal Transduction and Targeted Therapy
Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation, engendering transcript diversity, and modifications in protein structure and functionality. Across varying tissues, developmental stages, or under specific conditions,
Y. Tao, Qi Zhang, Haoyu Wang, Xiyu Yang, Haoran Mu   +4 more
semanticscholar   +1 more source

Nuclear-import receptors reverse aberrant phase transitions of RNA-binding proteins with prion-like domains

Cell, 2018
Summary RNA-binding proteins (RBPs) with prion-like domains (PrLDs) phase transition to functional liquids, which can mature into aberrant hydrogels composed of pathological fibrils that underpin fatal neurodegenerative disorders.
Lin Guo, Hong Joo Kim, H. Wang, J. Monaghan, F. Freyermuth, Julie C. Sung, K. O’Donovan, C. Fare, Zamia Diaz, Nikita Singh, Zi Chao Zhang, Maura Coughlin, Elizabeth A. Sweeny, Morgan E. DeSantis, Meredith E. Jackrel, C. Rodell, J. Burdick, O. King, A. Gitler, C. Lagier-Tourenne, U. Pandey, Y. Chook, J. Taylor, J. Shorter   +23 more
semanticscholar   +1 more source