Results 71 to 80 of about 3,111,959 (339)

Comprehensive landscape of the functions and prognostic value of RNA binding proteins in uterine corpus endometrial carcinoma

Frontiers in Molecular Biosciences, 2022
Background: The dysregulation of RNA binding proteins (RBPs) is involved in tumorigenesis and progression. However, information on the overall function of RNA binding proteins in Uterine Corpus Endometrial Carcinoma (UCEC) remains to be studied.
Yong Yao, Yong Yao, Yong Yao, Kangping Liu, Kangping Liu, Kangping Liu, Yuxuan Wu, Yuxuan Wu, Yuxuan Wu, Jieyu Zhou, Jieyu Zhou, Jieyu Zhou, Heyue Jin, Heyue Jin, Heyue Jin, Yimin Zhang, Yimin Zhang, Yimin Zhang, Yumin Zhu, Yumin Zhu, Yumin Zhu   +20 more
doaj   +1 more source

Specific binding of the methyl binding domain protein 2 at the BRCA1-NBR2 locus [PDF]

, 1996
The methyl-CpG binding domain (MBD) proteins are key molecules in the interpretation of DNA methylation signals leading to gene silencing. We investigated their binding specificity at the constitutively methylated region of a CpG island containing the ...
Auriol, Emilie, Billard, Lise-Marie, Magdinier, Frédérique, Dante, Robert   +3 more
core   +2 more sources

Beyond RNA-binding domains: determinants of protein–RNA binding

RNA
RNA-binding proteins (RBPs) are composed of RNA-binding domains (RBDs) often linked via intrinsically disordered regions (IDRs). Structural and biochemical analyses have shown that disordered linkers contribute to RNA binding by orienting the adjacent RBDs and also characterized certain disordered repeats that directly contact the RNA.
Zigdon, Inbal, Carmi, Miri, Brodsky, Sagie, Rosenwaser, Zohar, Barkai, Naama, Jonas, Felix   +5 more
openaire   +2 more sources

RNA-Binding Proteins in Pulmonary Hypertension [PDF]

International Journal of Molecular Sciences, 2020
Pulmonary hypertension (PH) is a life-threatening disease characterized by significant vascular remodeling and aberrant expression of genes involved in inflammation, apoptosis resistance, proliferation, and metabolism. Effective therapeutic strategies are limited, as mechanisms underlying PH pathophysiology, especially abnormal expression of genes ...
Hui Zhang, R. Dale Brown, Kurt R. Stenmark, Cheng-Jun Hu   +3 more
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Transcriptome-Wide Identification of Coding and Noncoding RNA-Binding Proteins Defines the Comprehensive RNA Interactome of Leishmania mexicana

Microbiology Spectrum, 2022
Proteomic profiling of RNA-binding proteins in Leishmania is currently limited to polyadenylated mRNA-binding proteins, leaving proteins that interact with nonadenylated RNAs, including noncoding RNAs and pre-mRNAs, unidentified.
Karunakaran Kalesh, Wenbin Wei, Brian S. Mantilla, Theodoros I. Roumeliotis, Jyoti Choudhary, Paul W. Denny   +5 more
doaj   +1 more source

Nucleic acid - protein fingerprints. Novel protein classification based on nucleic acid - protein recognition [PDF]

, 2012
Protein chemistry uses protein description and classification based on molecular mass and isoelectric point as general features. Enzymes are also compared by enzymatic reaction constants, namely Km and kcat values. Proteins are also studied by binding to
Alexander Krylov, Renad Zhdanov
core   +1 more source

Alternative polyadenylation and RNA-binding proteins [PDF]

Journal of Molecular Endocrinology, 2016
Our understanding of the extent of microRNA-based gene regulation has expanded in an impressive pace over the past decade. Now, we are beginning to better appreciate the role of 3′-UTR (untranslated region) cis-elements which harbor not only microRNA but also RNA-binding protein (RBP) binding sites that have significant effect on the stability and ...
openaire   +3 more sources

Trading translation with RNA-binding proteins [PDF]

RNA, 2008
RNA-binding proteins regulate every aspect of RNA metabolism, including pre-mRNA splicing, mRNA trafficking, stability, and translation. This review summarizes the available information on molecular mechanisms of translational repression by RNA-binding proteins.
Irina, Abaza, Fátima, Gebauer
openaire   +2 more sources

RNA‐PROTACs: Degraders of RNA‐Binding Proteins

Angewandte Chemie, 2020
Defects in the functions of RNA binding proteins (RBPs) are at the origin of many diseases; however, targeting RBPs with conventional drugs has proven difficult.
A. Ghidini, A. Cléry, François Halloy, F. Allain, Jonathan Hall   +4 more
semanticscholar   +1 more source