Results 91 to 100 of about 583,250 (311)

Computationally repurposed drugs and natural products against RNA dependent RNA polymerase as potential COVID-19 therapies

Molecular Biomedicine, 2021
Repurposing of existing drugs and drug candidates is an ideal approach to identify new potential therapies for SARS-CoV-2 that can be tested without delay in human trials of infected patients.
Sakshi Piplani, Puneet Kumar Singh, David A. Winkler, Nikolai Petrovsky   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

A Conserved GA Element in TATA-Less RNA Polymerase II Promoters [PDF]

, 2011
Initiation of RNA polymerase (Pol) II transcription requires assembly of the pre-initiation complex (PIC) at the promoter. In the classical view, PIC assembly starts with binding of the TATA box-binding protein (TBP) to the TATA box.
Hartmann, H., Kurth, F., Cramer, P., Hartmann, Holger, Hartmann Holger, Martin Dietmar E., Söding Johannes, Seizl, Martin, Kurth Fabian, Martin, D., Martin Seizl, Fabian Kurth, Cramer Patrick, Hoeg Friederike, Söding* Patrick Cramer, Martin, Dietmar E., Hoeg, F., Cramer, Patrick, Patrick Cramer, Soeding, J., Johannes Söding, Holger Hartmann, Hoeg, Frederike, Kurth, Fabian, Söding, J., Seizl, M., Seizl Martin, Söding, Johannes, Dietmar E Martin, Friederike Hoeg, Martin, D. E., Hoeg, Friederike, Dietmar E. Martin   +32 more
core   +1 more source

Flavivirus RNA-Dependent RNA Polymerase Interacts with Genome UTRs and Viral Proteins to Facilitate Flavivirus RNA Replication

Viruses, 2019
Flaviviruses, most of which are emerging and re-emerging human pathogens and significant public health concerns worldwide, are positive-sense RNA viruses. Flavivirus replication occurs on the ER and is regulated by many mechanisms and factors. NS5, which
YanPing Duan, Miao Zeng, Bowen Jiang, Wei Zhang, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Qiao Yang, Ying Wu, ShaQiu Zhang, YunYa Liu, Ling Zhang, YanLing Yu, Leichang Pan, Shun Chen, Anchun Cheng   +17 more
doaj   +1 more source

Glutathionylation of dengue and Zika NS5 proteins affects guanylyltransferase and RNA dependent RNA polymerase activities. [PDF]

PLoS ONE, 2018
It has been estimated for dengue infection that the global population at risk is 3.5 billion people, which makes dengue an important public health problem. The causative agents of dengue are dengue viruses.
Chonticha Saisawang, Atichat Kuadkitkan, Prasert Auewarakul, Duncan R Smith, Albert J Ketterman   +4 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

A coronavirus detected in the vampire bat Desmodus rotundus

Brazilian Journal of Infectious Diseases
This article reports on the identification of a group 2 coronavirus (BatCoV DR/2007) in a Desmodus rotundus vampire bat in Brazil. Phylogenetic analysis of ORF1b revealed that BatCoV DR/2007 originates from a unique lineage in the archetypical group 2 ...
Paulo Eduardo Brandão, Karin Scheffer, Laura Yaneth Villarreal, Samira Achkar, Rafael de Novaes Oliveira, Willian de Oliveira Fahl, Juliana Galera Castilho, Ivanete Kotait, Leonardo José Richtzenhain   +8 more
doaj   +1 more source

Origins and Evolution of the Global RNA Virome

mBio, 2018
Viruses with RNA genomes dominate the eukaryotic virome, reaching enormous diversity in animals and plants. The recent advances of metaviromics prompted us to perform a detailed phylogenomic reconstruction of the evolution of the dramatically expanded ...
Yuri I. Wolf, Darius Kazlauskas, Jaime Iranzo, Adriana Lucía-Sanz, Jens H. Kuhn, Mart Krupovic, Valerian V. Dolja, Eugene V. Koonin   +7 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source