Results 261 to 270 of about 763,502 (351)

Muscle‐Derived Small Extracellular Vesicles Mediate Exercise‐Induced Cognitive Protection in Chronic Cerebral Hypoperfusion

Advanced Science, EarlyView.
sEVs have a critical role in orchestrating interorgan crosstalk and mediating exercise‐induced therapeutic effects. Lin et al. demonstrates that sEVs miR‐17/20a‐5p mediates the muscle‐brain crosstalk and emphasizes the central role of mTOR signaling in executing molecular programs that can protect brain health in response to exercise. Abstract Physical
Huawei Lin, Lianhua Yin, Weilin Liu, Rui Li, Tao Jiang, Minguang Yang, Yajun Cao, Sinuo Wang, Yan Yu, Cong Chen, Xiaoqin Guo, Wenju Wang, Huanhuan Liu, Yaling Dai, Jiamin Yan, Yanting Lin, Yanyi Ding, Chendong Ruan, Lei Yang, Tiecheng Wu, Jing Tao, Lidian Chen   +21 more
wiley   +1 more source

Amentoflavone from Selaginella tamariscina inhibits SARS-CoV-2 RNA-dependent RNA polymerase. [PDF]

Heliyon
Youn KW, Lee S, Kim JH, Park YI, So J, Kim C, Cho CW, Park J.   +7 more
europepmc   +1 more source

Molecular and Structural Aspects of Clinically Relevant Mutations of SARS-CoV-2 RNA-Dependent RNA Polymerase in Remdesivir-Treated Patients. [PDF]

Pharmaceuticals (Basel), 2023
Gratteri C, Ambrosio FA, Lupia A, Moraca F, Catalanotti B, Costa G, Bellocchi M, Carioti L, Salpini R, Ceccherini-Silberstein F, Frazia S, Malagnino V, Sarmati L, Svicher V, Bryant S, Artese A, Alcaro S.   +16 more
europepmc   +1 more source

Sofosbuvir: A Potential Treatment for Ebola

Frontiers in Pharmacology, 2018
Sandra E. Reznik, Sandra E. Reznik, Amit K. Tiwari, Charles R. Ashby   +3 more
doaj   +1 more source

METTL14‐Mediated M6A Modification of LINC01094 Induces Glucose Metabolic Reprogramming in Breast Cancer by Recruiting the PKM2/JMJD5 Complex

Advanced Science, EarlyView.
METTL14/IGF2BP2‐mediated m6A modification drives LINC01094 upregulation in BC. Then, LINC01094 interacts with PKM2 monomers to promote their dimerization, while serving as a flexible scaffold to facilitate the assembly of the PKM2/JMJD5 complex, synergistically stabilizing PKM2 dimers and enhancing their nuclear translocation.
Mengqi Wang, Zhaoxin Gao, Ruinan Zhao, Pan Zhou, Jingxi Chen, Hui Zhang, Yawen Wang, Wenjie Zhu, Peng Gao   +8 more
wiley   +1 more source

Studies on the Conformation of DNA‐Dependent RNA Polymerase in Solution by Small‐Angle X‐Ray Measurements [PDF]

, 1972
Ingrid Pilz, O. Kratky, Dietmar Rabussay
openalex   +1 more source

RNA-dependent RNA polymerase of predominant human norovirus forms liquid-liquid phase condensates as viral replication factories. [PDF]

Sci Adv
Kaundal S, Anish R, Ayyar BV, Shanker S, Kaur G, Crawford SE, Pollet J, Stossi F, Estes MK, Prasad BVV.   +9 more
europepmc   +1 more source

Potential RNA-dependent RNA polymerase (RdRp) inhibitors as prospective drug candidates for SARS-CoV-2. [PDF]

Eur J Med Chem, 2023
Bekheit MS, Panda SS, Girgis AS.
europepmc   +1 more source

DNA‐dependent RNA polymerase from the thermophilic bacterium Thermus aquaticus

, 1974
Gillian M. Air, J. Ieuan Harris
openalex   +1 more source

Purification and Properties of the NAD⁺: Protein ADP‐ribosyltransferase Responsible for the T4‐Phage‐Induced Modification of the œ Subunit of DNA‐Dependent RNA Polymerase of Escherichia coli [PDF]

, 1977
Romuald Skórko, Wolfram Zillig, Hermann Rohrer, Hirota Fujiki, Reinhard MAlLHAMMER   +4 more
openalex   +1 more source