Results 261 to 270 of about 1,029,988 (373)

Structural basis of viral RNA-dependent RNA polymerase catalysis and translocation

Proceedings of the National Academy of Sciences of the United States of America, 2016
B. Shu, P. Gong
semanticscholar   +1 more source

Evaluating Cytocompatibility of Corynebacterium glutamicum‐poly Vinyl Alcohol Living Biomaterials for Ocular Use

Advanced Healthcare Materials, EarlyView.
In ophthalmology, living biomaterials such as living contact lenses appear promising for sustained drug delivery or biosensing. The cytocompatibility of Cg‐PVA hydrogels, developed as a model living contact lens, is investigated with the ocular surface, showing their potential translation to the clinic.
Krupansh Desai, Lorely Garcia‐Sanchez, Maryam Amini, Lara Luana Teruel‐Enrico, Silke Siegrist, Aránzazu del Campo, Sara Trujillo   +6 more
wiley   +1 more source

Sofosbuvir: A Potential Treatment for Ebola

Frontiers in Pharmacology, 2018
Sandra E. Reznik, Sandra E. Reznik, Amit K. Tiwari, Charles R. Ashby   +3 more
doaj   +1 more source

Impact of an oxidative RNA lesion on in vitro replication catalyzed by SARS-CoV-2 RNA-dependent RNA polymerase. [PDF]

J Biol Chem
Akagawa M, Sugasawa K, Ura K, Sassa A.
europepmc   +1 more source

Homology-Based Identification of a Mutation in the Coronavirus RNA-Dependent RNA Polymerase That Confers Resistance to Multiple Mutagens

Journal of Virology, 2016
Nicole R. Sexton, E. C. Smith, H. Blanc, M. Vignuzzi, O. Peersen, M. Denison   +5 more
semanticscholar   +1 more source

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

Dual-Site Inhibition of SARS-CoV-2 RNA-Dependent RNA Polymerase by Small Molecules Able to Block Viral Replication Identified through a Computer-Aided Drug Discovery Approach. [PDF]

ACS Infect Dis
Malune P, Iaconis D, Manelfi C, Giunta S, Emmolo R, Lunghini F, Paulis A, Talarico C, Corona A, Beccari AR, Tramontano E, Esposito F.   +11 more
europepmc   +1 more source

Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase

Proceedings of the National Academy of Sciences of the United States of America, 2010
P. Gong, O. Peersen
semanticscholar   +1 more source

Evaluating the Antiviral Efficacy of Encapsulated PKC Inhibitor BIM‐I against influenza A Virus Infection

Advanced Healthcare Materials, EarlyView.
This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide‐I (BIM‐I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles improved safety while maintaining the compound's strong antiviral activity.
Laura Klement, Jana Ismail, Josefine Schroeder, Amod Godbole, Johanna Schreiber, Christine Weber, Zoltan Cseresnyes, Marc T. Figge, Bettina Löffler, Ulrich S. Schubert, Stephanie Schubert, Christina Ehrhardt, Carsten Hoffmann   +12 more
wiley   +1 more source

Developing Allosteric Inhibitors of SARS-CoV-2 RNA-Dependent RNA Polymerase. [PDF]

ChemMedChem
Chayka A, Danda M, Dostálková A, Spiwok V, Klimešová A, Kapisheva M, Zgarbová M, Weber J, Ruml T, Rumlová M, Janeba Z.   +10 more
europepmc   +1 more source