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RNA editing of microRNA prevents RNA-induced silencing complex recognition of target mRNA [PDF]

open access: greenOpen Biology, 2015
MicroRNAs (miRNAs) integrate with Argonaut (Ago) to create the RNA-induced silencing complex, and regulate gene expression by silencing target mRNAs. RNA editing of miRNA may affect miRNA processing, assembly of the Ago complex and target mRNA binding ...
Yalei Cui   +2 more
doaj   +3 more sources

Critical role of backbone coordination in the mRNA recognition by RNA induced silencing complex [PDF]

open access: yesCommunications Biology, 2021
Lizhe Zhu et al. use a quasi Markov State Model built from extensive molecular dynamics simulations to elucidate the dynamics of RISC-mRNA interactions. Their results provide further insight on how a target nucleotide is positioned before recognition by ...
Lizhe Zhu   +5 more
doaj   +2 more sources

Oomycete small RNAs bind to the plant RNA-induced silencing complex for virulence [PDF]

open access: yeseLife, 2020
The exchange of small RNAs (sRNAs) between hosts and pathogens can lead to gene silencing in the recipient organism, a mechanism termed cross-kingdom RNAi (ck-RNAi).
Florian Dunker   +10 more
doaj   +2 more sources

RNA Interference by Single- and Double-stranded siRNA With a DNA Extension Containing a 3′ Nuclease-resistant Mini-hairpin Structure [PDF]

open access: yesMolecular Therapy: Nucleic Acids, 2014
Selective gene silencing by RNA interference (RNAi) involves double-stranded small interfering RNA (ds siRNA) composed of single-stranded (ss) guide and passenger RNAs.
Simon J Allison, Jo Milner
doaj   +8 more sources

The origin and effect of small RNA signaling in plants [PDF]

open access: yesFrontiers in Plant Science, 2012
Given their sessile condition, land plants need to integrate environmental cues rapidly and send signal throughout the organism to modify their metabolism accordingly. Small RNA (sRNA) molecules are among the messengers that plant cells use to carry such
Jean-Sébastien eParent   +2 more
doaj   +3 more sources

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