Results 141 to 150 of about 253,943 (166)

Hominoid-specific retrotransposons fuel regulatory novelty in early brain development. [PDF]

Cell Genom
Okorokova L, Cristofari G.
europepmc   +1 more source

Development of Triangle RNA Nanostructure for Enhancing RNAi-Mediated Control of <i>Botrytis cinerea</i> Through Spray-Induced Gene Silencing Without Extra Nanocarrier. [PDF]

Biology (Basel)
Chen Y, Liu Y, Huang Y, Wu F, Jin W.
europepmc   +1 more source

DROSHA, DICER, and damage-induced long ncRNA control BMI1-dependent transcriptional repression at DNA double-strand break.

Cell Rep
Esposito F, Capozzo I, Riccardi A, Gioia U, Modafferi S, Manfredi L, Colantoni A, Tavella S, Cabrini M, Iannelli F, di Lillo A, d'Adda di Fagagna F, Francia S.   +12 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Genetic variants in RNA-induced silencing complex genes and prostate cancer

World Journal of Urology, 2017
The purpose of this study is to evaluate the potential association between genetic variants in genes encoding the components of RNA-induced silencing complex and prostate cancer (PCa) risk. Genetic variants chosen for this study are rs3742330 in DICER1, rs4961280 in AGO2, rs784567 in TARBP2, rs7813 in GEMIN4 and rs197414 in GEMIN3.The study involved ...
Z. Nikolić, D. Pavićević, N. Vučić, S. Cerovic, V. Vukotić, G. Brajušković   +5 more
semanticscholar   +3 more sources

miRNA*: a passenger stranded in RNA-induced silencing complex?

Critical Reviews™ in Eukaryotic Gene Expression, 2010
Processing of the pre-microRNA (pre-miRNA) through Dicer1 generates a miRNA duplex, consisting of a miRNA and miRNA* strand (also termed guide strand and passenger strand, respectively). Despite the general consensus that miRNA*s have no regulatory activity, recent publications have provided evidence that the abundance, possible function, and ...
Sarah M. Mah, C. Buske, R. Humphries, F. Kuchenbauer   +3 more
semanticscholar   +3 more sources

Functional regulation of RNA-induced silencing complex by photoreactive oligonucleotides.

Bioorganic & Medicinal Chemistry, 2014
We developed a novel method for regulation of RISC function by photoreactive oligonucleotides (Ps-Oligo) containing 2'-O-psoralenylmethoxyethyl adenosine (Aps). We observed that inhibitory effects of Ps-Oligos on RISC function were enhanced by UV-irradiation compared with 2'-O-methyl-oligonucleotide without Aps. These results suggest Ps-Oligo inhibited
Yohei Matsuyama, A. Yamayoshi, A. Kobori, A. Murakami   +3 more
semanticscholar   +3 more sources

The Interactomics of the RNA-Induced Silencing Complex

, 2018
The posttranscriptional gene silencing mechanism initially mistaken as co-suppression but later identified as RNA interference mediated and regulated by small interfering RNAs (siRNAs), and microRNAs (miRNAs) has gradually emerged as a landmark discovery of the last decade.
A. Datta, S. Ganguli
semanticscholar   +2 more sources

RNA-Induced Silencing Complex-Bound Small Interfering RNA Is a Determinant of RNA Interference-Mediated Gene Silencing in Mice

Molecular Pharmacology, 2011
Deeper knowledge of pharmacokinetic and pharmacodynamic (PK/PD) concepts for RNA therapeutics is important to streamline the drug development process and for rigorous selection of best performing drug candidates. Here we characterized the PK/PD relationship for small interfering RNAs (siRNAs) targeting luciferase by examining siRNA concentration in ...
Jie Wei, Jeffrey J. Jones, Jing Kang, A. Card, Michael Krimm, Paula J. Hancock, Y. Pei, B. Ason, Elmer Payson, N. Dubinina, M. Cancilla, M. Stroh, J. Burchard, A. Sachs, J. Hochman, W. Flanagan, N. Kuklin, Rna Delivery   +17 more
semanticscholar   +3 more sources

Induction and biochemical purification of RNA-induced silencing complex from Drosophila S2 cells.

Methods in molecular biology, 2004
The discovery of RNA interference (RNAi) has greatly simplified the process of suppressing genes in many experimental systems, including Caenorhabditis elegans, Drosophila, and mammalian cells. A sequence-specific nuclease complex, called the RNA-induced silencing complex (RISC), can be purified from cells undergoing RNAi.
A. Caudy, G. Hannon
semanticscholar   +3 more sources