Results 141 to 150 of about 167,761 (271)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Alexander disease (AxD) is a severe neurodegenerative disorder caused by gain‐of‐function mutations in the gene for GFAP, which lead to protein aggregation and a primary astrocytopathy. Symptoms vary, but failure to thrive (FTT) and frequent emesis are common and cause significant morbidity. Here we investigate GDF15, a member of the
Tracy L. Hagemann +6 more
wiley +1 more source
MicroRNAs in the Stressed Heart: Sorting the Signal from the Noise
Cells, 2014 The short noncoding RNAs, known as microRNAs, are of undisputed importance in cellular signaling during differentiation and development, and during adaptive and maladaptive responses of adult tissues, including those that comprise the heart.
Scot J. Matkovich
doaj +1 more source
Advanced Biology, EarlyView.The study reveals that RRP9 is abnormally highly expressed in ESCC tissues and is closely associated with poor prognosis in patients. Furthermore, it is found that RRP9 promotes ESCC progression through enhancing the E2F1‐mediated transcriptional regulation of CDK1.
Gang He +14 more
wiley +1 more source
Targeting the eIF4A RNA helicase blocks translation of the MUC1-C oncoprotein [PDF]
, 2012 The oncogenic MUC1-C subunit is aberrantly overexpressed in most human breast cancers by mechanisms that are not well understood. The present studies demonstrate that stimulation of non- malignant MCF-10A cells with epidermal growth factor (EGF) or ...
Jin, Caining +4 more
core +1 more source
Advanced Functional Materials, EarlyView.A biofabricated 3D in vitro model recapitulating endochondral ossification (ECO) is described, mimicking the steps from condensation to chondrogenesis and hypertrophy, culminating with vascularization of the hypertrophic construct. As a model proof of concept application, Ewing Sarcoma cells are seeded in the model, showing modifications in their ...
Maria Vittoria Colombo +13 more
wiley +1 more source
Data from SND1, a Component of RNA-Induced Silencing Complex, Is Up-regulated in Human Colon Cancers and Implicated in Early Stage Colon Carcinogenesis [PDF]
, 2023 Naoto Tsuchiya +5 more
openalex +1 more source
浙江大学学报. 农业与生命科学版, 2008 The term virus-induced gene silencing' (VIGS) was first used to describe the phenomenon of recovery from virus infection, a natural plant antiviral mechanism, which recently has been exploited as a genetic technique involving recombinant viruses with a ...
XU You-ping +4 more
doaj +1 more source
Effect of Non-Coding RNA on Post-Transcriptional Gene Silencing of Alzheimer Disease [PDF]
, 2010 A large amount of hidden biological information is contained in the human genome, which is not expressed or revealed in the form of proteins; the usual end product form of gene expression.
Arun Mohan +7 more
core +1 more source
Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery
Advanced Functional Materials, EarlyView.This study provides an efficient approach to train a machine learning model by merging heterogeneous literature data to predict suitable polymers for siRNA delivery. Without the need for extensive laboratory synthesis, the machine learning enabled a virtual screening and successfully predicted a polymer that is validated for effective gene silencing in
Felix Sieber‐Schäfer +10 more
wiley +1 more source
Overlapping functions of argonaute proteins in patterning and morphogenesis of Drosophila embryos.
PLoS Genetics, 2006 Argonaute proteins are essential components of the molecular machinery that drives RNA silencing. In Drosophila, different members of the Argonaute family of proteins have been assigned to distinct RNA silencing pathways.
Wibke J Meyer +5 more
doaj +1 more source