Results 11 to 20 of about 286,999 (296)

High-throughput analysis of the RNA-induced silencing complex in myotonic dystrophy type 1 patients identifies the dysregulation of miR-29c and its target ASB2. [PDF]

Cell Death Dis, 2018
Cappella M, Perfetti A, Cardinali B, Garcia-Manteiga JM, Carrara M, Provenzano C, Fuschi P, Cardani R, Renna LV, Meola G, Falcone G, Martelli F.   +11 more
europepmc   +3 more sources

Comprehensive Evolutionary Analysis of the Major RNA-Induced Silencing Complex Members. [PDF]

Sci Rep, 2018
Zhang R, Jing Y, Zhang H, Niu Y, Liu C, Wang J, Zen K, Zhang CY, Li D.   +8 more
europepmc   +3 more sources

Optimized protocols for RNA-induced silencing complex assembly and cleavage in cultured Drosophila cells. [PDF]

STAR Protoc, 2022
Gao Y, Zhu Y, Sun Q, Chen D.
europepmc   +2 more sources

Remote precursor elements can modulate RNA induced silencing complex-loading efficiency of miR168 in Arabidopsis. [PDF]

Plant J
Dalmadi Á, Miloro F, Abdu A, Kis A, Havelda Z.   +4 more
europepmc   +2 more sources

C-terminal tagging impairs AGO2 function [PDF]

RNA Biology
MicroRNA-mediated gene silencing is a conserved mechanism of post-transcriptional gene regulation across metazoans. It depends on base pairing between small RNAs and mRNAs, and on protein complexes including the RNA-induced silencing complex (RISC ...
Kunal M. Shah, Alex F. F. Crozier, Anika Assaraf, Muzjda Arya, Paul Grevitt, Faraz Mardakheh, Michael J. Plevin, Tyson V. Sharp   +7 more
doaj   +2 more sources

Inhibiting MicroRNA function globally to target cancer: an emerging new scenario [PDF]

World Cancer Research Journal, 2020
MicroRNA (miRNA) is an important class of small non-coding RNAs that act as post-transcriptional modulators of gene expression, and whose dysregulation has been implicated in various stages of cancer development. Although promising experimental evidences
G. La Rocca, M. Mauro
doaj   +1 more source

Development of a Viral RdRp-Assisted Gene Silencing System and Its Application in the Identification of Host Factors of Plant (+)RNA Virus

Frontiers in Microbiology, 2021
Gene silencing induced by hairpin RNA or virus infection expression is one of the major tools in genetics studies in plants. However, when dealing with essential genes, virus-induced gene silencing (VIGS) and transgenic expression of hairpin RNA could ...
Wang Zhang, Yanglin Qiu, Lingyun Zhou, Jinlong Yin, Liqun Wang, Haijian Zhi, Kai Xu   +6 more
doaj   +1 more source

Dimerisation of the PICTS complex via LC8/Cut-up drives co-transcriptional transposon silencing in Drosophila

eLife, 2021
In animal gonads, the PIWI-interacting RNA (piRNA) pathway guards genome integrity in part through the co-transcriptional gene silencing of transposon insertions.
Evelyn L Eastwood, Kayla A Jara, Susanne Bornelöv, Marzia Munafò, Vasileios Frantzis, Emma Kneuss, Elisar J Barbar, Benjamin Czech, Gregory J Hannon   +8 more
doaj   +1 more source

RNA interference approaches for plant disease control

BioTechniques, 2020
Plant diseases caused by a variety of pathogens can have severe effects on crop plants and even plants in natural ecosystems. Despite many effective conventional approaches to control plant diseases, new, efficacious, environmentally sound and cost ...
Yen-Wen Kuo, Bryce W Falk
doaj   +1 more source

Silencing of Ago-2 Interacting Protein SERBP1 Relieves KCC2 Repression by miR-92 in Neurons

Cells, 2022
RNA-binding proteins (RBPs) play important roles in modulating miRNA-mediated mRNA target repression. Argonaute2 (Ago2) is an essential component of the RNA-induced silencing complex (RISC) that plays a central role in silencing mechanisms via small non ...
Christian Barbato, Paola Frisone, Laura Braccini, Simona D’Aguanno, Luisa Pieroni, Maria Teresa Ciotti, Caterina Catalanotto, Carlo Cogoni, Francesca Ruberti   +8 more
doaj   +1 more source