Through a comprehensive multi‐omics analysis, this study identifies a marked reduction in Nephronectin (NPNT) expression within fibrotic lung tissue. This reduction impairs the binding capability to the ITGA3 receptor, consequently causing YAP1 to persist in the cytoplasm, where it undergoes degradation.
Jiayu Guo+20 more
wiley +1 more source
The relationship between HERVs and exogenous viral infections: A focus on the value of HERVs in disease prediction and treatment. [PDF]
Dou A, Xu J, Zhou C.
europepmc +1 more source
Epidemiological data confirm obesity elevates thoracic aortic dissection (TAD) risk. Patient analyses implicate hyperleptinemia, where leptin binding to vascular smooth muscle cell (VSMC) receptors triggers Socs3‐mediated suppression of Stat5a transcriptional activity.
Ling Chen+18 more
wiley +1 more source
ATF3 Deficiency Exacerbates Ageing‐Induced Atherosclerosis and Clinical Intervention Strategy
Targeting ATF3 with terazosin to against VSMC Senescence and atherosclerosis. TZ reduces the binding affinity of YTHDF2 to Atf3 mRNA, while enhancing mRNA stability. ATF3 promotes Atg7 transcription, enhancing autophagy. ATG7 binds to ATF3 in the cytoplasm, facilitating ATF3 translocation to the nucleus and establishing positive feedback. By modulating
Hao Nie+11 more
wiley +1 more source
Integrating RNA Interference and Nanotechnology: A Transformative Approach in Plant Protection. [PDF]
Islam MS+11 more
europepmc +1 more source
Regulation of RNA-induced silencing complex by Leishmania: Targeting of host Argonaute-interactome
D. S. Brar, A Reiner
openalex +1 more source
Advances in Small RNA Regulation of Female Gametophyte Development in Flowering Plants. [PDF]
Liu Y+6 more
europepmc +1 more source
hnRNPH1: A Multifaceted Regulator in RNA Processing and Disease Pathogenesis. [PDF]
Zhu L+9 more
europepmc +1 more source
SARS-CoV-2-Derived RNA Fragment Induces Myocardial Dysfunction via siRNA-like Suppression of Mitochondrial ATP Synthase. [PDF]
Nukaga S+15 more
europepmc +1 more source
Regulation of Petal Coloration by the Auxin Amide Hydrolase Gene <i>RhILL1</i> in Rose (<i>Rosa hybrida</i>). [PDF]
Wang D+10 more
europepmc +1 more source