Results 231 to 240 of about 224,288 (284)

Nephronectin (NPNT) is a Crucial Determinant of Idiopathic Pulmonary Fibrosis: Modulating Cellular Senescence via the ITGA3/YAP1 Signaling Axis

Advanced Science, EarlyView.
Through a comprehensive multi‐omics analysis, this study identifies a marked reduction in Nephronectin (NPNT) expression within fibrotic lung tissue. This reduction impairs the binding capability to the ITGA3 receptor, consequently causing YAP1 to persist in the cytoplasm, where it undergoes degradation.
Jiayu Guo, Yan Wang, Qiudi Liu, Zhaoyang Luo, Xiaomu Tian, Yuquan Wang, Yang Liu, Zhiwei Ning, Yingying Guo, Huiying Gao, Xinyue Wang, Jinglong Feng, Mengmeng Liu, Dina Saifullina, Yixin Zhang, Tengfei Pan, Yu Bian, Tao Ban, Tianyu Li, Yunyan Gu, Haihai Liang   +20 more
wiley   +1 more source

The relationship between HERVs and exogenous viral infections: A focus on the value of HERVs in disease prediction and treatment. [PDF]

Virulence
Dou A, Xu J, Zhou C.
europepmc   +1 more source

Leptin Aggravates Thoracic Aortic Dissection Through Impairment of Energy Metabolism in Nrip2+ Smooth Muscle Cells

Advanced Science, EarlyView.
Epidemiological data confirm obesity elevates thoracic aortic dissection (TAD) risk. Patient analyses implicate hyperleptinemia, where leptin binding to vascular smooth muscle cell (VSMC) receptors triggers Socs3‐mediated suppression of Stat5a transcriptional activity.
Ling Chen, Yujie Zhu, Xi Yang, JiangBin Wu, Keyuan Chen, Wuqing Huang, Lu Fang, Qi Zhang, Jie Chen, Jianing Gao, Huanhuan Cao, Meifang Wu, Zhihuang Qiu, Yuling Zhang, Yue Shen, Qiuyu Huang, Zhiyong Lin, Lemin Zheng, Liangwan Chen   +18 more
wiley   +1 more source

ATF3 Deficiency Exacerbates Ageing‐Induced Atherosclerosis and Clinical Intervention Strategy

Advanced Science, EarlyView.
Targeting ATF3 with terazosin to against VSMC Senescence and atherosclerosis. TZ reduces the binding affinity of YTHDF2 to Atf3 mRNA, while enhancing mRNA stability. ATF3 promotes Atg7 transcription, enhancing autophagy. ATG7 binds to ATF3 in the cytoplasm, facilitating ATF3 translocation to the nucleus and establishing positive feedback. By modulating
Hao Nie, Tianyi Ji, Zixin Wan, Jie Huang, Han Li, Lingjiao Zou, Zhen Yang, Jiarui Li, Yuqi Guan, Lei Ruan, Jinhua Yan, Cuntai Zhang   +11 more
wiley   +1 more source

Integrating RNA Interference and Nanotechnology: A Transformative Approach in Plant Protection. [PDF]

Plants (Basel)
Islam MS, Ahmed MR, Noman M, Zhang Z, Wang J, Lu Z, Cai Y, Ahmed T, Li B, Wang Y, Golam Sarwar AKM, Wang J.   +11 more
europepmc   +1 more source

Regulation of RNA-induced silencing complex by Leishmania: Targeting of host Argonaute-interactome

D. S. Brar, A Reiner
openalex   +1 more source

Advances in Small RNA Regulation of Female Gametophyte Development in Flowering Plants. [PDF]

Plants (Basel)
Liu Y, He Q, Su H, Xi X, Xu X, Qin Y, Cai H.   +6 more
europepmc   +1 more source

hnRNPH1: A Multifaceted Regulator in RNA Processing and Disease Pathogenesis. [PDF]

Int J Mol Sci
Zhu L, Yi W, Zhang L, Qiu C, Sun N, He J, Feng P, Wu Q, Wang G, Wu G.   +9 more
europepmc   +1 more source

SARS-CoV-2-Derived RNA Fragment Induces Myocardial Dysfunction via siRNA-like Suppression of Mitochondrial ATP Synthase. [PDF]

Int J Mol Sci
Nukaga S, Fujiwara-Tani R, Mori T, Kawahara I, Nishida R, Miyagawa Y, Goto K, Ohmori H, Fujii K, Sasaki T, Nakashima C, Luo Y, Mori S, Kishi S, Ogata R, Kuniyasu H.   +15 more
europepmc   +1 more source

Regulation of Petal Coloration by the Auxin Amide Hydrolase Gene <i>RhILL1</i> in Rose (<i>Rosa hybrida</i>). [PDF]

Genes (Basel)
Wang D, Zhang Y, Li D, Ma X, Yang X, Jian H, Wang H, Wang L, Zhang H, Wang Q, Qiu X.   +10 more
europepmc   +1 more source