Results 231 to 240 of about 224,288 (284)

Nephronectin (NPNT) is a Crucial Determinant of Idiopathic Pulmonary Fibrosis: Modulating Cellular Senescence via the ITGA3/YAP1 Signaling Axis

open access: yesAdvanced Science, EarlyView.
Through a comprehensive multi‐omics analysis, this study identifies a marked reduction in Nephronectin (NPNT) expression within fibrotic lung tissue. This reduction impairs the binding capability to the ITGA3 receptor, consequently causing YAP1 to persist in the cytoplasm, where it undergoes degradation.
Jiayu Guo   +20 more
wiley   +1 more source

Leptin Aggravates Thoracic Aortic Dissection Through Impairment of Energy Metabolism in Nrip2+ Smooth Muscle Cells

open access: yesAdvanced Science, EarlyView.
Epidemiological data confirm obesity elevates thoracic aortic dissection (TAD) risk. Patient analyses implicate hyperleptinemia, where leptin binding to vascular smooth muscle cell (VSMC) receptors triggers Socs3‐mediated suppression of Stat5a transcriptional activity.
Ling Chen   +18 more
wiley   +1 more source

ATF3 Deficiency Exacerbates Ageing‐Induced Atherosclerosis and Clinical Intervention Strategy

open access: yesAdvanced Science, EarlyView.
Targeting ATF3 with terazosin to against VSMC Senescence and atherosclerosis. TZ reduces the binding affinity of YTHDF2 to Atf3 mRNA, while enhancing mRNA stability. ATF3 promotes Atg7 transcription, enhancing autophagy. ATG7 binds to ATF3 in the cytoplasm, facilitating ATF3 translocation to the nucleus and establishing positive feedback. By modulating
Hao Nie   +11 more
wiley   +1 more source

Integrating RNA Interference and Nanotechnology: A Transformative Approach in Plant Protection. [PDF]

open access: yesPlants (Basel)
Islam MS   +11 more
europepmc   +1 more source

hnRNPH1: A Multifaceted Regulator in RNA Processing and Disease Pathogenesis. [PDF]

open access: yesInt J Mol Sci
Zhu L   +9 more
europepmc   +1 more source

SARS-CoV-2-Derived RNA Fragment Induces Myocardial Dysfunction via siRNA-like Suppression of Mitochondrial ATP Synthase. [PDF]

open access: yesInt J Mol Sci
Nukaga S   +15 more
europepmc   +1 more source

Regulation of Petal Coloration by the Auxin Amide Hydrolase Gene <i>RhILL1</i> in Rose (<i>Rosa hybrida</i>). [PDF]

open access: yesGenes (Basel)
Wang D   +10 more
europepmc   +1 more source

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