Results 261 to 270 of about 167,761 (271)
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Regulation and different functions of the animal microRNA‐induced silencing complex
Wiley Interdisciplinary Reviews - RNA, 2021Among the different types of small RNAs, microRNAs (miRNAs) are key players in controlling gene expression at the mRNA level. To be active, they must associate with an Argonaute protein to form the miRNA induced silencing complex (miRISC) and binds to ...
Pierre-Marc Frédérick, M. J. Simard
semanticscholar +1 more source
Cancer Research, 2011
Abstract Objectives: There is virtually no treatment for advanced hepatocellular carcinoma (HCC). As such novel targets need to be identified to develop effective therapies to combat this fatal disease. The oncogene Astrocyte elevated gene-1 (AEG-1) is overexpressed in more than 90% of human HCC patients and plays a seminal role in ...
Dong Chen +6 more
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Abstract Objectives: There is virtually no treatment for advanced hepatocellular carcinoma (HCC). As such novel targets need to be identified to develop effective therapies to combat this fatal disease. The oncogene Astrocyte elevated gene-1 (AEG-1) is overexpressed in more than 90% of human HCC patients and plays a seminal role in ...
Dong Chen +6 more
openaire +2 more sources
AGO2 and its partners: a silencing complex, a chromatin modulator, and new features
Critical reviews in biochemistry and molecular biology, 2020AGO2 is the only member with catalytic activity in Argonaute family and contains four functional core domains, which are N domain, PAZ domain, MID domain, and PIWI domain from N-terminal to C-terminal.
Xiaojing Li +3 more
semanticscholar +1 more source
2017
Small RNA-mediated gene silencing is involved in a variety of biological processes among many eukaryotic organisms. The silencing effector, generally referred to as RNA-induced silencing complex (RISC), comprises an ARGONAUTE (AGO) protein and a small single-stranded guide RNA in its core. RISCs recognize target genes containing sequences complementary
Masayuki Ishikawa +2 more
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Small RNA-mediated gene silencing is involved in a variety of biological processes among many eukaryotic organisms. The silencing effector, generally referred to as RNA-induced silencing complex (RISC), comprises an ARGONAUTE (AGO) protein and a small single-stranded guide RNA in its core. RISCs recognize target genes containing sequences complementary
Masayuki Ishikawa +2 more
openaire +3 more sources
Nucleic Acid Therapeutics, 2017
MicroRNAs (miRNAs) regulate gene expression by forming RNA-induced silencing complexes (RISCs) and have been considered as promising therapeutic targets. MiRNA is an essential component of RISC for the modulation of gene expression. Therefore, the release of miRNA from RISC is considered as an effective method for the inhibition of miRNA functions.
Hiroshi Sugiyama +5 more
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MicroRNAs (miRNAs) regulate gene expression by forming RNA-induced silencing complexes (RISCs) and have been considered as promising therapeutic targets. MiRNA is an essential component of RISC for the modulation of gene expression. Therefore, the release of miRNA from RISC is considered as an effective method for the inhibition of miRNA functions.
Hiroshi Sugiyama +5 more
openaire +3 more sources
[Components and assembly of RNA-induced silencing complex].
Yi chuan = Hereditas, 2009Degradation of homologous RNA in RNA interference is carried out by functional RNA-induced silencing complex (RISC). RISC contains Dicer, Argonaute proein, siRNA and other components. Researching structures and functions of these components is primary important for understanding assembly and functional mechanism of RISC, as well as the whole RNAi ...
Xue-Mei, Song, Fei, Yan, Li-Xin, Du
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