RNA-induced silencing complex (RISC) Proteins PACT, TRBP, and Dicer are SRA binding nuclear receptor coregulators [PDF]
Proceedings of the National Academy of Sciences, 2013 The cytoplasmic RNA-induced silencing complex (RISC) contains dsRNA binding proteins, including protein kinase RNA activator (PACT), transactivation response RNA binding protein (TRBP), and Dicer, that process pre-microRNAs into mature microRNAs (miRNAs) that target specific mRNA species for regulation.
Andrew Redfern +20 more
semanticscholar +5 more sources
Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity [PDF]
Proceedings of the National Academy of Sciences, 2004 RNA interference is carried out by the small double-stranded RNA-induced silencing complex (RISC). The RISC-bound small RNA guides the RISC complex to identify and cleave mRNAs with complementary sequences. The proteins that make up the RISC complex and cleave mRNA have not been unequivocally defined.
Tim Rand +3 more
semanticscholar +4 more sources
The 5′-end heterogeneity of adenovirus virus-associated RNAI contributes to the asymmetric guide strand incorporation into the RNA-induced silencing complex [PDF]
Nucleic Acids Research, 2009 Human Adenovirus type 5 encodes two short RNA polymerase III transcripts, the virus-associated (VA) RNAI and VA RNAII, which can adopt stable hairpin structures that resemble micro-RNA precursors.
Ning Xu +3 more
openalex +2 more sources
PLoS ONE, 2010 Background GW/P bodies are cytoplasmic ribonucleoprotein-rich foci involved in microRNA (miRNA)-mediated messenger RNA (mRNA) silencing and degradation. The mRNA regulatory functions within GW/P bodies are mediated by GW182 and its binding partner hAgo2 ...
Joanna J. Moser, Marvin J. Fritzler
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In Arabidopsis thaliana, RNA-Induced Silencing Complex-Loading of MicroRNAs Plays a Minor Regulatory Role During Photomorphogenesis Except for miR163. [PDF]
Front Plant Sci, 2022 Lakatos L, Groma G, Silhavy D, Nagy F.
europepmc +2 more sources
miR-7 is recruited to the high molecular weight RNA-induced silencing complex in CD8+ T cells upon activation and suppresses IL-2 signaling. [PDF]
RNA, 2023 Toivakka M +6 more
europepmc +3 more sources
Life of RISC: Formation, action, and degradation of RNA-induced silencing complex.
Molecular Cell, 2021 Small RNAs regulate a wide variety of biological processes by repressing the expression of target genes at the transcriptional and post-transcriptional levels. To achieve these functions, small RNAs form RNA-induced silencing complex (RISC) together with a member of the Argonaute (AGO) protein family.
Hirotaka Iwakawa, Yukihide Tomari
semanticscholar +3 more sources
RISC in Development; A Review on RNA Induced Silencing Complex and its Contribution to Cellular Differentiation [PDF]
International Journal of Hematology-Oncology and Stem Cell Research, 2011 Messenger RNAs may be targeted by short 19-27 nt RNAs generally called Small none-coding RNAs (snRNAs), the role of miRNAs among other snRNAs has been more studied and is well known. Many researches show that all compartments of RISC, Proteins and miRNAs
Amirali Davoudpour
doaj +3 more sources