Using RNAi in the treatment of cardiovascular diseases - therapeutics based on siRNA overview
Journal of Education, Health and Sport, 2022 RNA interference (RNAi) discovered in the 1990s by Fire and Mello plays a role in silencing gene function. One type of RNAi is siRNA, which is a double-stranded molecule of 20-25 base pairs.
Barbara Rusinowska
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Argonaute2 is essential for mammalian gastrulation and proper mesoderm formation. [PDF]
PLoS Genetics, 2007 Mammalian Argonaute proteins (EIF2C1-4) play an essential role in RNA-induced silencing. Here, we show that the loss of eIF2C2 (Argonaute2 or Ago2) results in gastrulation arrest, ectopic expression of Brachyury (T), and mesoderm expansion. We identify a
Reid S Alisch +4 more
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Emerging connections between small RNAs and phytohormones [PDF]
, 2020 Small RNAs (sRNAs), mainly including miRNAs and siRNAs, are ubiquitous in eukaryotes. sRNAs mostly negatively regulate gene expression via (post-)transcriptional gene silencing through DNA methylation, mRNA cleavage, or translation inhibition.
Dubois, Marieke +3 more
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Structural insights into RNA processing by the human RISC-loading complex. [PDF]
, 2009 Targeted gene silencing by RNA interference (RNAi) requires loading of a short guide RNA (small interfering RNA (siRNA) or microRNA (miRNA)) onto an Argonaute protein to form the functional center of an RNA-induced silencing complex (RISC).
AD Haase +41 more
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Enhancement of Recombinant Protein Production in Transgenic Nicotiana benthamiana Plant Cell Suspension Cultures with Co-Cultivation of Agrobacterium Containing Silencing Suppressors. [PDF]
, 2018 We have previously demonstrated that the inducible plant viral vector (CMViva) in transgenic plant cell cultures can significantly improve the productivity of extracellular functional recombinant human alpha-1-antiryspin (rAAT) compared with either a ...
Dandekar, Abhaya M +3 more
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TRBP and eIF6 homologue in Marsupenaeus japonicus play crucial roles in antiviral response. [PDF]
PLoS ONE, 2012 Plants and invertebrates can suppress viral infection through RNA silencing, mediated by RNA-induced silencing complex (RISC). Trans-activation response RNA-binding protein (TRBP), consisting of three double-stranded RNA-binding domains, is a component ...
Shuai Wang +4 more
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Blanks, a nuclear siRNA/dsRNA-binding complex component, is required for Drosophila spermiogenesis [PDF]
, 2011 Small RNAs and a diverse array of protein partners control gene expression in eukaryotes through a variety of mechanisms. By combining siRNA affinity chromatography and mass spectrometry, we have identified the double-stranded RNA-binding domain protein ...
Cummins, T. D. +5 more
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RNA duplexes in transcriptional regulation
Biomolecular Concepts, 2010 Transcriptional regulation by small RNA molecules, including small interfering RNA and microRNA, has emerged as an important gene expression modulator.
Swaminathan Sanjay +3 more
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Transfer RNA-derived small RNAs in the cancer transcriptome [PDF]
, 2016 The cellular lifetime includes stages such as differentiation, proliferation, division, senescence and apoptosis.These stages are driven by a strictly ordered process of transcription dynamics.
A Dueck +38 more
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Role of RNA Interference (RNAi) in the Moss Physcomitrella patens [PDF]
, 2013 RNA interference (RNAi) is a mechanism that regulates genes by either transcriptional (TGS) or posttranscriptional gene silencing (PTGS), required for genome maintenance and proper development of an organism.
Arif, Muhammad Asif +2 more
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