Results 31 to 40 of about 315,328 (199)
Inhibiting MicroRNA function globally to target cancer: an emerging new scenario [PDF]
World Cancer Research Journal, 2020 MicroRNA (miRNA) is an important class of small non-coding RNAs that act as post-transcriptional modulators of gene expression, and whose dysregulation has been implicated in various stages of cancer development. Although promising experimental evidences
G. La Rocca, M. Mauro
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Frontiers in Microbiology, 2021 Gene silencing induced by hairpin RNA or virus infection expression is one of the major tools in genetics studies in plants. However, when dealing with essential genes, virus-induced gene silencing (VIGS) and transgenic expression of hairpin RNA could ...
Wang Zhang +6 more
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The RNA-induced Silencing Complex: A Versatile Gene-silencing Machine [PDF]
Journal of Biological Chemistry, 2009 RNA interference is a powerful mechanism of gene silencing that underlies many aspects of eukaryotic biology. On the molecular level, RNA interference is mediated by a family of ribonucleoprotein complexes called RNA-induced silencing complexes (RISCs), which can be programmed to target virtually any nucleic acid sequence for silencing.
Ashley J, Pratt, Ian J, MacRae
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RNA interference approaches for plant disease control
BioTechniques, 2020 Plant diseases caused by a variety of pathogens can have severe effects on crop plants and even plants in natural ecosystems. Despite many effective conventional approaches to control plant diseases, new, efficacious, environmentally sound and cost ...
Yen-Wen Kuo, Bryce W Falk
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eLife, 2021 In animal gonads, the PIWI-interacting RNA (piRNA) pathway guards genome integrity in part through the co-transcriptional gene silencing of transposon insertions.
Evelyn L Eastwood +8 more
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RNA Interference by Single- and Double-stranded siRNA With a DNA Extension Containing a 3′ Nuclease-resistant Mini-hairpin Structure [PDF]
, 2009 Selective gene silencing by RNA interference (RNAi) involves double-stranded small interfering RNA (ds siRNA) composed of single-stranded (ss) guide and passenger RNAs.
Allison, Simon J., Milner, Jo
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Regulation of RNA-induced silencing complex by Leishmania: Targeting of host Argonaute-interactome
Archives of Microbiology & ImmunologyD. S. Brar, A Reiner
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Silencing of Ago-2 Interacting Protein SERBP1 Relieves KCC2 Repression by miR-92 in Neurons
Cells, 2022 RNA-binding proteins (RBPs) play important roles in modulating miRNA-mediated mRNA target repression. Argonaute2 (Ago2) is an essential component of the RNA-induced silencing complex (RISC) that plays a central role in silencing mechanisms via small non ...
Christian Barbato +8 more
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Emerging connections between small RNAs and phytohormones [PDF]
, 2020 Small RNAs (sRNAs), mainly including miRNAs and siRNAs, are ubiquitous in eukaryotes. sRNAs mostly negatively regulate gene expression via (post-)transcriptional gene silencing through DNA methylation, mRNA cleavage, or translation inhibition.
Dubois, Marieke +3 more
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Structural insights into RNA processing by the human RISC-loading complex. [PDF]
, 2009 Targeted gene silencing by RNA interference (RNAi) requires loading of a short guide RNA (small interfering RNA (siRNA) or microRNA (miRNA)) onto an Argonaute protein to form the functional center of an RNA-induced silencing complex (RISC).
AD Haase +41 more
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