Results 31 to 40 of about 253,943 (166)

High-throughput analysis of the RNA-induced silencing complex in myotonic dystrophy type 1 patients identifies the dysregulation of miR-29c and its target ASB2. [PDF]

Cell Death Dis, 2018
Cappella M, Perfetti A, Cardinali B, Garcia-Manteiga JM, Carrara M, Provenzano C, Fuschi P, Cardani R, Renna LV, Meola G, Falcone G, Martelli F.   +11 more
europepmc   +3 more sources

Adenovirus Virus-Associated RNAII-Derived Small RNAs Are Efficiently Incorporated into the RNA-Induced Silencing Complex and Associate with Polyribosomes

Journal of Virology, 2007
Ning Xu, Bo Segerman, Xiaofu Zhou, Göran Akusjärvi   +3 more
openalex   +3 more sources

Inhibiting MicroRNA function globally to target cancer: an emerging new scenario [PDF]

World Cancer Research Journal, 2020
MicroRNA (miRNA) is an important class of small non-coding RNAs that act as post-transcriptional modulators of gene expression, and whose dysregulation has been implicated in various stages of cancer development. Although promising experimental evidences
G. La Rocca, M. Mauro
doaj   +1 more source

MicroRNAs are tightly associated with RNA-induced gene silencing complexes in vivo

Biochemical and Biophysical Research Communications, 2008
Previous work has shown that synthesized siRNA/miRNA is tightly associated with RNA-induced Gene Silencing Complexes (RISCs) in vitro. However, it is unknown if the endogenous miRNAs are also stably bound to RISC complexes in vivo in cells under physiological conditions.
Fuchou Tang, Petra Hájková, Dónal O’Carroll, Caroline Lee, Alexander Tarakhovsky, Kaiqin Lao, M. Azim Surani   +6 more
openalex   +4 more sources

Dehydration-Induced Phase Transition of Argonaute1 (Ago1) Attenuates Rna-Induced Silencing Complex (Risc) Activity

, 2023
Tae Rin Oh, Hyun Ju Jung, Woorim Yang, Jee‐Eun Kim, Min Han, Christian Møller, Moon Young Ryu, Hari Chandana Yadavalli, Sukwon Choi, Young Kyoung Oh, Donghyuk Kim, Jin Young Shin, Tae‐Hwan Kim, Jong Hum Kim, Taijoon Chung, Jae‐Hoon Jung, Phil Hyu Lee, Woo Taek Kim, Seok Keun Cho, Seong Wook Yang   +19 more
openalex   +2 more sources

Tryptophan As a New Member of RNA‐Induced Silencing Complexes Prevents Colon Cancer Liver Metastasis [PDF]

Advanced Science
AbstractEssential amino acids (EAA) and microRNAs (miRs) control biological activity of a cell. Whether EAA regulates the activity of miR has never been demonstrated. Here, as proof‐of‐concept, a tryptophan (Trp, an EAA) complex containing Argonaute 2 (Ago2) and miRs including miR‐193a (Trp/Ago2/miR‐193a) is identified.
Fangyi Xu, Yi Ren, Yun Teng, Jingyao Mu, Jie Tang, Kumaran Sundaram, Lifeng Zhang, Juw Won Park, Jae Yeon Hwang, Jun Yan, Gerald W. Dryden, Huang‐Ge Zhang   +11 more
openalex   +4 more sources

A Structured Viroid RNA Serves as a Substrate for Dicer-Like Cleavage To Produce Biologically Active Small RNAs but Is Resistant to RNA-Induced Silencing Complex-Mediated Degradation

Journal of Virology, 2007
Asuka Itaya, Xuehua Zhong, Ralf Bundschuh, Yijun Qi, Ying Wang, Ryuta Takeda, Ann R. Harris, Carlos A. Molina, Richard S. Nelson, Biao Ding   +9 more
openalex   +2 more sources

Development of a Viral RdRp-Assisted Gene Silencing System and Its Application in the Identification of Host Factors of Plant (+)RNA Virus

Frontiers in Microbiology, 2021
Gene silencing induced by hairpin RNA or virus infection expression is one of the major tools in genetics studies in plants. However, when dealing with essential genes, virus-induced gene silencing (VIGS) and transgenic expression of hairpin RNA could ...
Wang Zhang, Yanglin Qiu, Lingyun Zhou, Jinlong Yin, Liqun Wang, Haijian Zhi, Kai Xu   +6 more
doaj   +1 more source

Remote precursor elements can modulate RNA induced silencing complex-loading efficiency of miR168 in Arabidopsis. [PDF]

Plant J
SUMMARYRNA interference mediated via the action of micro RNAs (miRNAs) plays a pivotal role in developmental and stress response pathways. In the nucleus, plant miRNAs are generated by subsequent enzymatic cuts of the MIRNA precursors, having specific hairpin‐like secondary structures, to liberate the miRNA/miRNA* duplex.
Dalmadi Á, Miloro F, Abdu A, Kis A, Havelda Z.   +4 more
europepmc   +3 more sources

In Vitro Assembly of Plant RNA-Induced Silencing Complexes Facilitated by Molecular Chaperone HSP90 [PDF]

Molecular Cell, 2010
RNA-induced silencing complexes (RISCs) play central roles in posttranscriptional gene silencing. In plants, the mechanism of RISC assembly has remained elusive due to the lack of cell-free systems that recapitulate the process. In this report, we demonstrate that plant AGO1 protein synthesized by in vitro translation using an extract of evacuolated ...
Taichiro Iki, Manabu Yoshikawa, Masaki Nishikiori, Mauren Jaudal, Eiko Matsumoto-Yokoyama, Ichiro Mitsuhara, Tetsuo Meshi, Masayuki Ishikawa   +7 more
openalex   +3 more sources