Results 41 to 50 of about 457,045 (298)
Silencing of Ago-2 Interacting Protein SERBP1 Relieves KCC2 Repression by miR-92 in Neurons
Cells, 2022 RNA-binding proteins (RBPs) play important roles in modulating miRNA-mediated mRNA target repression. Argonaute2 (Ago2) is an essential component of the RNA-induced silencing complex (RISC) that plays a central role in silencing mechanisms via small non ...
Christian Barbato +8 more
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Using RNAi in the treatment of cardiovascular diseases - therapeutics based on siRNA overview
Journal of Education, Health and Sport, 2022 RNA interference (RNAi) discovered in the 1990s by Fire and Mello plays a role in silencing gene function. One type of RNAi is siRNA, which is a double-stranded molecule of 20-25 base pairs.
Barbara Rusinowska
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Argonaute2 is essential for mammalian gastrulation and proper mesoderm formation. [PDF]
PLoS Genetics, 2007 Mammalian Argonaute proteins (EIF2C1-4) play an essential role in RNA-induced silencing. Here, we show that the loss of eIF2C2 (Argonaute2 or Ago2) results in gastrulation arrest, ectopic expression of Brachyury (T), and mesoderm expansion. We identify a
Reid S Alisch +4 more
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The Effect of Silence Feature in Dimensional Speech Emotion Recognition [PDF]
10th International Conference on Speech Prosody 2020, 26-30, 2020 Silence is a part of human-to-human communication, which can be a clue for human emotion perception. For automatic emotion recognition by a computer, it is not clear whether silence is useful to determine human emotion within a speech. This paper presents an investigation of the effect of using silence feature in dimensional emotion recognition.
arxiv +1 more source
CCR4-NOT Deadenylates mRNA Associated with RNA-Induced Silencing Complexes in Human Cells [PDF]
Molecular and Cellular Biology, 2010 MicroRNAs (miRNAs) repress gene expression posttranscriptionally by inhibiting translation and by expediting deadenylation so as to trigger rapid mRNA decay. Their regulatory influence is mediated by the protein components of the RNA-induced silencing complex (RISC), which deliver miRNAs and siRNAs to their mRNA targets.
Joel G. Belasco +4 more
openaire +3 more sources
ADAR1 Forms a Complex with Dicer to Promote MicroRNA Processing and RNA-Induced Gene Silencing [PDF]
Cell, 2013 Adenosine deaminases acting on RNA (ADARs) are involved in RNA editing that converts adenosine residues to inosine specifically in double-stranded RNAs. In this study, we investigated the interaction of the RNA editing mechanism with the RNA interference (RNAi) machinery and found that ADAR1 forms a complex with Dicer through direct protein-protein ...
Ota, H. +8 more
openaire +4 more sources
TRBP and eIF6 homologue in Marsupenaeus japonicus play crucial roles in antiviral response. [PDF]
PLoS ONE, 2012 Plants and invertebrates can suppress viral infection through RNA silencing, mediated by RNA-induced silencing complex (RISC). Trans-activation response RNA-binding protein (TRBP), consisting of three double-stranded RNA-binding domains, is a component ...
Shuai Wang +4 more
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RNA duplexes in transcriptional regulation
Biomolecular Concepts, 2010 Transcriptional regulation by small RNA molecules, including small interfering RNA and microRNA, has emerged as an important gene expression modulator.
Swaminathan Sanjay +3 more
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When RNA and protein degradation pathways meet
Frontiers in Plant Science, 2014 RNA silencing has become a major focus of molecular and biomedical research in the last decade. This mechanism, which is conserved in most eukaryotes, has been extensively studied and is associated to various pathways implicated in the regulation of ...
Pascal eGENSCHIK, Benoit eDerrien
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High fidelity optogenetic control of individual prefrontal cortical pyramidal neurons in vivo [PDF]
F1000 Research 2012, 1:7, 2012 Precise spatial and temporal manipulation of neural activity in specific genetically defined cell populations is now possible with the advent of optogenetics. The emerging field of optogenetics consists of a set of naturally-occurring and engineered light-sensitive membrane proteins that are able to activate (e.g., channelrhodopsin-2, ChR2) or silence (
arxiv +1 more source