eLife, 2021 In animal gonads, the PIWI-interacting RNA (piRNA) pathway guards genome integrity in part through the co-transcriptional gene silencing of transposon insertions.
Evelyn L Eastwood +8 more
doaj +1 more source
RNA interference approaches for plant disease control
BioTechniques, 2020 Plant diseases caused by a variety of pathogens can have severe effects on crop plants and even plants in natural ecosystems. Despite many effective conventional approaches to control plant diseases, new, efficacious, environmentally sound and cost ...
Yen-Wen Kuo, Bryce W Falk
doaj +1 more source
Decision letter: Oomycete small RNAs bind to the plant RNA-induced silencing complex for virulence
, 2020 Michael J. Axtell
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Silencing of Ago-2 Interacting Protein SERBP1 Relieves KCC2 Repression by miR-92 in Neurons
Cells, 2022 RNA-binding proteins (RBPs) play important roles in modulating miRNA-mediated mRNA target repression. Argonaute2 (Ago2) is an essential component of the RNA-induced silencing complex (RISC) that plays a central role in silencing mechanisms via small non ...
Christian Barbato +8 more
doaj +1 more source
ADAR1 Forms a Complex with Dicer to Promote MicroRNA Processing and RNA-Induced Gene Silencing [PDF]
Cell, 2013 Adenosine deaminases acting on RNA (ADARs) are involved in RNA editing that converts adenosine residues to inosine specifically in double-stranded RNAs. In this study, we investigated the interaction of the RNA editing mechanism with the RNA interference (RNAi) machinery and found that ADAR1 forms a complex with Dicer through direct protein-protein ...
Hiromitsu Ota +8 more
semanticscholar +5 more sources
Argonaute2 is essential for mammalian gastrulation and proper mesoderm formation. [PDF]
PLoS Genetics, 2007 Mammalian Argonaute proteins (EIF2C1-4) play an essential role in RNA-induced silencing. Here, we show that the loss of eIF2C2 (Argonaute2 or Ago2) results in gastrulation arrest, ectopic expression of Brachyury (T), and mesoderm expansion. We identify a
Reid S Alisch +4 more
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Using RNAi in the treatment of cardiovascular diseases - therapeutics based on siRNA overview
Journal of Education, Health and Sport, 2022 RNA interference (RNAi) discovered in the 1990s by Fire and Mello plays a role in silencing gene function. One type of RNAi is siRNA, which is a double-stranded molecule of 20-25 base pairs.
Barbara Rusinowska
doaj +1 more source
Structural insights into RNA processing by the human RISC-loading complex. [PDF]
, 2009 Targeted gene silencing by RNA interference (RNAi) requires loading of a short guide RNA (small interfering RNA (siRNA) or microRNA (miRNA)) onto an Argonaute protein to form the functional center of an RNA-induced silencing complex (RISC).
AD Haase +41 more
core +2 more sources
Determination of mRNA Targets of miR-376c within the RNA-Induced Silencing Complex
Diseases and Research, 2023 Ines Stevic, Heidi Schwarzenbach
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The roles of microRNA in redox metabolism and exercise-mediated adaptation
Journal of Sport and Health Science, 2020 MicroRNAs (miRs) are small regulatory RNA transcripts capable of post-transcriptional silencing of mRNA messages by entering a cellular bimolecular apparatus called RNA-induced silencing complex.
Ferenc Torma +7 more
doaj +1 more source