Results 51 to 60 of about 253,943 (166)

TRBP and eIF6 homologue in Marsupenaeus japonicus play crucial roles in antiviral response. [PDF]

PLoS ONE, 2012
Plants and invertebrates can suppress viral infection through RNA silencing, mediated by RNA-induced silencing complex (RISC). Trans-activation response RNA-binding protein (TRBP), consisting of three double-stranded RNA-binding domains, is a component ...
Shuai Wang, An-Jing Chen, Li-Jie Shi, Xiao-Fan Zhao, Jin-Xing Wang   +4 more
doaj   +1 more source

Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology

Nature Communications, 2018
The RNA-induced silencing complex (RISC) represses gene expression via micro-RNA guided mRNA silencing. Here, the authors show that RISC component Argonaute 2 in the liver regulates energy metabolism by inducing microRNAs that cause metabolic disruption ...
Cai Zhang, Joonbae Seo, Kazutoshi Murakami, Esam S. B. Salem, Elise Bernhard, Vishnupriya J. Borra, Kwangmin Choi, Celvie L. Yuan, Calvin C. Chan, Xiaoting Chen, Taosheng Huang, Matthew T. Weirauch, Senad Divanovic, Nathan R. Qi, Hala Einakat Thomas, Carol A. Mercer, Haruhiko Siomi, Takahisa Nakamura   +17 more
doaj   +1 more source

When RNA and protein degradation pathways meet

Frontiers in Plant Science, 2014
RNA silencing has become a major focus of molecular and biomedical research in the last decade. This mechanism, which is conserved in most eukaryotes, has been extensively studied and is associated to various pathways implicated in the regulation of ...
Pascal eGENSCHIK, Benoit eDerrien
doaj   +1 more source

The RNA-binding Protein TDP-43 Selectively Disrupts MicroRNA-1/206 Incorporation into the RNA-induced Silencing Complex*♦

Journal of Biological Chemistry, 2014
Background: Regulation of microRNA activity independent of processing and biogenesis has not been demonstrated. Results: The RNA-binding protein, TDP-43, interacts with mature miR-1/miR-206, limiting their RNA-induced silencing complex (RISC) association
I. King, V. Yartseva, Donaldo Salas, Abhishek Kumar, A. Heidersbach, D. Michael Ando, N. R. Stallings, J. Elliott, D. Srivastava, Kathryn N. Ivey   +9 more
semanticscholar   +1 more source

Topoisomerase 3β interacts with RNAi machinery to promote heterochromatin formation and transcriptional silencing in Drosophila

Nature Communications, 2018
Topoisomerases solve topological problems during DNA metabolism, but their role in RNA metabolism remains unclear. Here the authors provide evidence that in Drosophila, Topoisomerase 3β interacts biochemically and genetically with the RNAi-induced ...
Seung Kyu Lee, Yutong Xue, Weiping Shen, Yongqing Zhang, Yuyoung Joo, Muzammil Ahmad, Madoka Chinen, Yi Ding, Wai Lim Ku, Supriyo De, Elin Lehrmann, Kevin G. Becker, Elissa P. Lei, Keji Zhao, Sige Zou, Alexei Sharov, Weidong Wang   +16 more
doaj   +1 more source

A calmodulin-like protein suppresses RNA silencing and promotes geminivirus infection by degrading SGS3 via the autophagy pathway in Nicotiana benthamiana.

PLoS Pathogens, 2017
A recently characterized calmodulin-like protein is an endogenous RNA silencing suppressor that suppresses sense-RNA induced post-transcriptional gene silencing (S-PTGS) and enhances virus infection, but the mechanism underlying calmodulin-like protein ...
Fangfang Li, Nan Zhao, Zhenghe Li, Xiongbiao Xu, Yaqin Wang, Xiuling Yang, Shu-Sheng Liu, Aiming Wang, Xueping Zhou   +8 more
doaj   +1 more source

Supplementary Figure Legends 1-5 from SND1, a Component of RNA-Induced Silencing Complex, Is Up-regulated in Human Colon Cancers and Implicated in Early Stage Colon Carcinogenesis [PDF]

, 2023
Naoto Tsuchiya, Masako Ochiai, Katsuhiko Nakashima, Tsuneyuki Ubagai, Takashi Sügimura, Hitoshi Nakagama   +5 more
openalex   +2 more sources

ADAR1 Forms a Complex with Dicer to Promote MicroRNA Processing and RNA-Induced Gene Silencing [PDF]

Cell, 2013
Adenosine deaminases acting on RNA (ADARs) are involved in RNA editing that converts adenosine residues to inosine specifically in double-stranded RNAs. In this study, we investigated the interaction of the RNA editing mechanism with the RNA interference (RNAi) machinery and found that ADAR1 forms a complex with Dicer through direct protein-protein ...
Hiromitsu Ota, M. Sakurai, Ravi Gupta, L. Valente, B. Wulff, Kentaro Ariyoshi, H. Iizasa, R. Davuluri, K. Nishikura   +8 more
semanticscholar   +4 more sources

The origin and effect of small RNA signaling in plants

Frontiers in Plant Science, 2012
Given their sessile condition, land plants need to integrate environmental cues rapidly and send signal throughout the organism to modify their metabolism accordingly. Small RNA (sRNA) molecules are among the messengers that plant cells use to carry such
Jean-Sébastien eParent, Angel Emilio eMartinez de Alba, Hervé eVaucheret   +2 more
doaj   +1 more source

NF90 interacts with components of RISC and modulates association of Ago2 with mRNA

BMC Biology, 2022
Background Nuclear factor 90 (NF90) is a double-stranded RNA-binding protein involved in a multitude of different cellular mechanisms such as transcription, translation, viral infection, and mRNA stability.
Giuseppa Grasso, Charbel Akkawi, Celine Franckhauser, Rima Nait-Saidi, Maxime Bello, Jérôme Barbier, Rosemary Kiernan   +6 more
doaj   +1 more source