Results 51 to 60 of about 457,045 (298)
Nature Communications, 2018 The RNA-induced silencing complex (RISC) represses gene expression via micro-RNA guided mRNA silencing. Here, the authors show that RISC component Argonaute 2 in the liver regulates energy metabolism by inducing microRNAs that cause metabolic disruption ...
Cai Zhang +17 more
doaj +1 more source
PLoS Pathogens, 2017 A recently characterized calmodulin-like protein is an endogenous RNA silencing suppressor that suppresses sense-RNA induced post-transcriptional gene silencing (S-PTGS) and enhances virus infection, but the mechanism underlying calmodulin-like protein ...
Fangfang Li +8 more
doaj +1 more source
Nature Communications, 2018 Topoisomerases solve topological problems during DNA metabolism, but their role in RNA metabolism remains unclear. Here the authors provide evidence that in Drosophila, Topoisomerase 3β interacts biochemically and genetically with the RNAi-induced ...
Seung Kyu Lee +16 more
doaj +1 more source
NF90 interacts with components of RISC and modulates association of Ago2 with mRNA
BMC Biology, 2022 Background Nuclear factor 90 (NF90) is a double-stranded RNA-binding protein involved in a multitude of different cellular mechanisms such as transcription, translation, viral infection, and mRNA stability.
Giuseppa Grasso +6 more
doaj +1 more source
The Impact of Silence on Speech Anti-Spoofing [PDF]
arXiv, 2023 The current speech anti-spoofing countermeasures (CMs) show excellent performance on specific datasets. However, removing the silence of test speech through Voice Activity Detection (VAD) can severely degrade performance. In this paper, the impact of silence on speech anti-spoofing is analyzed.
arxiv
The role of multiple marks in epigenetic silencing and the emergence of a stable bivalent chromatin state [PDF]
PLoS Comput Biol 9(7): e1003121, 2012 We introduce and analyze a minimal model of epigenetic silencing in budding yeast, built upon known biomolecular interactions in the system. Doing so, we identify the epigenetic marks essential for the bistability of epigenetic states. The model explicitly incorporates two key chromatin marks, namely H4K16 acetylation and H3K79 methylation, and ...
arxiv +1 more source
The origin and effect of small RNA signaling in plants
Frontiers in Plant Science, 2012 Given their sessile condition, land plants need to integrate environmental cues rapidly and send signal throughout the organism to modify their metabolism accordingly. Small RNA (sRNA) molecules are among the messengers that plant cells use to carry such
Jean-Sébastien eParent +2 more
doaj +1 more source
Life in the Cosmos: Paradox of Silence and Self-Awareness [PDF]
arXiv, 2023 As humanity embarks on an age of exploration, the question of whether we are alone in the universe remains unanswered. This comprehensive review reflects on the paradoxical nature of our existence in a seemingly lifeless cosmos, delving into the silence we encounter and the depths of our self-awareness.
arxiv
Time-delayed model of RNA interference [PDF]
Ecol. Compl. 30, 11-25 (2017), 2016 RNA interference (RNAi) is a fundamental cellular process that inhibits gene expression through cleavage and destruction of target mRNA. It is responsible for a number of important intracellular functions, from being the first line of immune defence against pathogens to regulating development and morphogenesis.
arxiv +1 more source
Speech is Silver, Silence is Golden: What do ASVspoof-trained Models Really Learn? [PDF]
ASVspoof 2021 Workshop, 2021 We present our analysis of a significant data artifact in the official 2019/2021 ASVspoof Challenge Dataset. We identify an uneven distribution of silence duration in the training and test splits, which tends to correlate with the target prediction label.
arxiv