Results 61 to 70 of about 253,943 (166)

GoldenBraid-compatible infectious clone of apple latent spherical virus (ALSV) and its use for virus-induced gene silencing

Biologia Plantarum
Virus-induced gene silencing (VIGS) is a technological process in which the expression of a plant target gene is down-regulated by inoculating a plant with a recombinant virus-based vector carrying part of the coding sequence of the target gene ...
Hana HOFFMEISTEROVÁ, Jakub DUŠEK, Emad IBRAHIM, Tomáš MORAVEC, Jiban Kumar KUNDU   +4 more
doaj   +1 more source

Argonaute 2 inhibits RIG-I signaling via competition for viral RNA binding

iScience
Summary: Interferon (IFN)-dependent responses constitute a critical initial defense against viruses in mammalian cells, while RNA interference (RNAi) acts as an additional strategy to combat invading viral pathogens.
Honglian Liu, Yingyin Liao, Fei Yu, Leo Ngo-Shing Li, Yajie Zhang, Lin Zhu, Guangshan Xie, Jiayan Liu, Siwen Liu, Shaofeng Deng, Rachel Chun-Yee Tam, Wenjun Song, Pin Chen, Xiaofeng Huang, Conor J. Cremin, Yixin Chen, Min Zheng, Pui Wang, Zongwei Cai, Kwok-Yung Yuen, Honglin Chen, Bobo Wing-Yee Mok   +21 more
doaj   +1 more source

Strand Analysis, a free online program for the computational identification of the best RNA interference (RNAi) targets based on Gibbs free energy

Genetics and Molecular Biology, 2007
The RNA interference (RNAi) technique is a recent technology that uses double-stranded RNA molecules to promote potent and specific gene silencing. The application of this technique to molecular biology has increased considerably, from gene function ...
Tiago Campos Pereira, Vinícius D'Ávila Pascoal Bittencourt, Rodrigo Secolin, Cristiane de Souza Rocha, Ivan de Godoy Maia, Iscia Lopes-Cendes   +5 more
doaj   +1 more source

Multifaceted Capsid Proteins: Multiple Interactions Suggest Multiple Roles for Pepino mosaic virus Capsid Protein

Molecular Plant-Microbe Interactions, 2014
Pepino mosaic virus (PepMV) (family Alphaflexiviridae, genus Potexvirus) is a mechanically transmitted tomato pathogen that, over the last decade, has evolved from emerging to endemic worldwide.
Matthaios M. Mathioudakis, Luis Rodríguez-Moreno, Raquel Navarro Sempere, Miguel A. Aranda, Ioannis Livieratos   +4 more
doaj   +1 more source

siRNA-AGO2 complex inhibits bacterial gene translation: A promising therapeutic strategy for superbug infection

Cell Reports Medicine
Summary: Silencing resistance genes of pathogenic bacteria by RNA interference (RNAi) is a potential strategy to fight antibiotic-resistant bacterial infections.
Chen Wang, Wangjian Sheng, Yu Zhou, Xudong Hang, Jiayi Zhao, Yuanyuan Gu, Xiangfeng Meng, Yuefan Bai, Weili Li, Yujing Zhang, Linlin Zhang, Jing Yu, Zhen Zhou, Xiaona Li, Haorui Sun, Yanhong Xue, Tao Xu, Ke Zen, Hong Ling, Chen-Yu Zhang, Hongkai Bi, Huan Wang   +21 more
doaj   +1 more source

The Long Non-Coding RNA XIST Controls Non-Small Cell Lung Cancer Proliferation and Invasion by Modulating miR-186-5p

Cellular Physiology and Biochemistry, 2017
Background/Aims: Long non-coding RNAs (lncRNAs) are key players in the development and progression of human cancers. The lncRNA XIST (X-inactive specific transcript) has been shown to be upregulated in human non-small cell lung cancer (NSCLC); however ...
Haoyou Wang, Qiming Shen, Xin Zhang, Chunlu Yang, Su Cui, Yanbin Sun, Liming Wang, Xiaoxi Fan, Shun Xu   +8 more
doaj   +1 more source

Regulation of RNA-induced silencing complex by Leishmania: Targeting of host Argonaute-interactome

Archives of Microbiology & Immunology
D. S. Brar, A Reiner
openalex   +2 more sources

Enzymatically produced pools of canonical and Dicer-substrate siRNA molecules display comparable gene silencing and antiviral activities against herpes simplex virus. [PDF]

PLoS ONE, 2012
RNA interference (RNAi)-based sequence-specific gene silencing is applied to identify gene function and also possesses great potential for inhibiting virus replication both in animals and plants.
Alesia Romanovskaya, Henrik Paavilainen, Michaela Nygårdas, Dennis H Bamford, Veijo Hukkanen, Minna M Poranen   +5 more
doaj   +1 more source

Classification of and detection techniques for RNAi-induced effects in GM plants

Frontiers in Plant Science
RNA interference (RNAi) is a biotechnological tool used for gene silencing in plants, with both endogenous and exogenous applications. Endogenous approaches, such as host-induced gene silencing (HIGS), involve genetically modified (GM) plants, while ...
Cecilia Diaz, Steve U. Ayobahan, Samson Simon, Luise Zühl, Andreas Schiermeyer, Elke Eilebrecht, Sebastian Eilebrecht   +6 more
doaj   +1 more source

RNA processing errors triggered by cadmium and integrator complex disruption are signals for environmental stress

BMC Biology, 2019
Background Adaptive responses to stress are essential for cell and organismal survival. In metazoans, little is known about the impact of environmental stress on RNA homeostasis.
Cheng-Wei Wu, Keon Wimberly, Adele Pietras, William Dodd, M. Blake Atlas, Keith P. Choe   +5 more
doaj   +1 more source