Results 71 to 80 of about 253,943 (166)
Microbiology Spectrum, 2023 Some insect viruses encode suppressors of RNA interference (RNAi) to counteract the antiviral RNAi pathway. However, it is unknown whether Bombyx mori cytoplasmic polyhedrosis virus (BmCPV) encodes an RNAi suppressor. In this study, the presence of viral
Jun Pan +8 more
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Thermodynamic control of small RNA-mediated gene silencing
Frontiers in Genetics, 2012 Small interfering RNAs (siRNAs) and microRNAs (miRNAs) are crucial regulators of posttranscriptional gene silencing, which is referred to as RNA interference (RNAi) or RNA silencing.
Kumiko eUi-Tei +3 more
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Innate Immunity Activation and RNAi Interplay in Citrus Exocortis Viroid—Tomato Pathosystem
Viruses, 2018 Although viroids are the smallest and simplest plant pathogens known, the molecular mechanisms underlying their pathogenesis remain unclear. To unravel these mechanisms, a dual approach was implemented consisting of in silico identification of potential ...
Thibaut Olivier, Claude Bragard
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Gene Silencing: The Mechanism to Down Regulate the Target Gene
International Journal of Bio-Resource and Stress Management, 2018 Gene silencing is one of the most efficient and promising functional genomics tools which down regulates the expression of a gene in a very precise manner and has significant impact on crop improvement.
Shreya +2 more
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Plant microRNAs: Biogenesis, Homeostasis, and Degradation
Frontiers in Plant Science, 2019 MicroRNAs (miRNAs), a class of endogenous, tiny, non-coding RNAs, are master regulators of gene expression among most eukaryotes. Intracellular miRNA abundance is regulated under multiple levels of control including transcription, processing, RNA ...
Junli Wang, Jun Mei, Guodong Ren
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Computational methods for ab initio detection of microRNAs
Frontiers in Genetics, 2012 MicroRNAs are small RNA sequences of 18-24 nucleotides in length, which serve as templates to drive post transcriptional gene silencing. The canonical microRNA pathway starts with transcription from DNA and is followed by processing via the ...
Malik eYousef, Jens eAllmer
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PLoS Pathogens, 2020 In this study, we investigated the significance of a conserved five-amino acid motif ‘AELPR’ in the C-terminal region of helper component–proteinase (HCPro) for potato virus A (PVA; genus Potyvirus) infection.
Swarnalok De +3 more
semanticscholar +1 more source
5′ Unlocked Nucleic Acid Modification Improves siRNA Targeting
Molecular Therapy: Nucleic Acids, 2013 Optimization of small interfering RNAs (siRNAs) is important in RNA interference (RNAi)-based therapeutic development. Some specific chemical modifications can control which siRNA strand is selected by the RNA-induced silencing complex (RISC) for gene ...
Nicholas M Snead +3 more
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Condensin Promotes Position Effects within Tandem DNA Repeats via the RITS Complex
Cell Reports, 2016 Summary: Tandem repetitive DNA is highly abundant in eukaryotic genomes and contributes to transcription control and genome stability. However, how the individual sequences within tandem repeats behave remains largely unknown.
Haijin He +4 more
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