Results 81 to 90 of about 167,761 (271)

Synaptotagmin 11 interacts with components of the RNA‐induced silencing complex RISC in clonal pancreatic β‐cells [PDF]

FEBS Letters, 2014
Synaptotagmins are two C2 domain‐containing transmembrane proteins. The function of calcium‐sensitive members in the regulation of post‐Golgi traffic has been well established whereas little is known about the calcium‐insensitive isoforms constituting half of the protein family. Novel binding partners of synaptotagmin 11 were identified in β‐cells.
Anne Dominique Lajoix, Jean-Marie Schmitter, Marie-Noëlle Benassy, Begoña Ochoa, J. Papin, Valérie Lagrée, Stéphane Chaignepain, Alexandra Milochau, Laetitia Coudert, Itsaso Garcia-Arcos, Jochen Lang, Carole Monterrat   +11 more
openaire   +2 more sources

The Long Non-Coding RNA XIST Controls Non-Small Cell Lung Cancer Proliferation and Invasion by Modulating miR-186-5p

Cellular Physiology and Biochemistry, 2017
Background/Aims: Long non-coding RNAs (lncRNAs) are key players in the development and progression of human cancers. The lncRNA XIST (X-inactive specific transcript) has been shown to be upregulated in human non-small cell lung cancer (NSCLC); however ...
Haoyou Wang, Qiming Shen, Xin Zhang, Chunlu Yang, Su Cui, Yanbin Sun, Liming Wang, Xiaoxi Fan, Shun Xu   +8 more
doaj   +1 more source

Саногенетичне обгрунтування застосування бальзаму "Трускавецький" для реабілітації імунодисфункції [PDF]

, 2008
In this thesis we studied various aspects of siRNA mediated silencing. siRNA mediated silencing is initiated by the introduction of dsRNA, transgenes and viral infection.
Чебаненко, Л.О., Лужецький, О.Г., Флюнт, І.С.   +2 more
core  

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Multifaceted Capsid Proteins: Multiple Interactions Suggest Multiple Roles for Pepino mosaic virus Capsid Protein

Molecular Plant-Microbe Interactions, 2014
Pepino mosaic virus (PepMV) (family Alphaflexiviridae, genus Potexvirus) is a mechanically transmitted tomato pathogen that, over the last decade, has evolved from emerging to endemic worldwide.
Matthaios M. Mathioudakis, Luis Rodríguez-Moreno, Raquel Navarro Sempere, Miguel A. Aranda, Ioannis Livieratos   +4 more
doaj   +1 more source

Enzymatically produced pools of canonical and Dicer-substrate siRNA molecules display comparable gene silencing and antiviral activities against herpes simplex virus. [PDF]

PLoS ONE, 2012
RNA interference (RNAi)-based sequence-specific gene silencing is applied to identify gene function and also possesses great potential for inhibiting virus replication both in animals and plants.
Alesia Romanovskaya, Henrik Paavilainen, Michaela Nygårdas, Dennis H Bamford, Veijo Hukkanen, Minna M Poranen   +5 more
doaj   +1 more source

Interaction between Bombyx mori Cytoplasmic Polyhedrosis Virus NSP8 and BmAgo2 Inhibits RNA Interference and Enhances Virus Proliferation

Microbiology Spectrum, 2023
Some insect viruses encode suppressors of RNA interference (RNAi) to counteract the antiviral RNAi pathway. However, it is unknown whether Bombyx mori cytoplasmic polyhedrosis virus (BmCPV) encodes an RNAi suppressor. In this study, the presence of viral
Jun Pan, Qunnan Qiu, Dhiraj Kumar, Jian Xu, Xinyu Tong, Zeen Shen, Min Zhu, Xiaolong Hu, Chengliang Gong   +8 more
doaj   +1 more source

Nucleotide bias of DCL and AGO in plant anti-virus gene silencing [PDF]

, 2010
Plant Dicer-like (DCL) and Argonaute (AGO) are the key enzymes involved in anti-virus post-transcriptional gene silencing (AV-PTGS). Here we show that AV-PTGS exhibited nucleotide preference by calculating a relative AV-PTGS efficiency on processing ...
Dalmay, Tamas, Ho, Thien, Huang, Linfeng, Li, Zhigang, Ohshima, Kazusato, Pallett, Denise W., Walsh, John A., Wang, Hui, Wang, Liang   +8 more
core   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

RNA processing errors triggered by cadmium and integrator complex disruption are signals for environmental stress

BMC Biology, 2019
Background Adaptive responses to stress are essential for cell and organismal survival. In metazoans, little is known about the impact of environmental stress on RNA homeostasis.
Cheng-Wei Wu, Keon Wimberly, Adele Pietras, William Dodd, M. Blake Atlas, Keith P. Choe   +5 more
doaj   +1 more source