Results 151 to 160 of about 4,240,750 (265)
Rationalizing the effects of RNA modifications on protein interactions
Molecular Therapy: Nucleic AcidsRNA modifications play a crucial role in regulating gene expression by altering RNA structure and modulating interactions with RNA-binding proteins (RBPs).
Andrea Vandelli +4 more
doaj +1 more source
RNA-binding proteins shape biology through their widespread functions in RNA biochemistry. Their function requires the recognition of specific RNA motifs for targeted binding.
Aoki, Scott Takeo +7 more
core +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection
Molecular Oncology, EarlyView.Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński +12 more
wiley +1 more source
Functions of RNAi Pathways in Ribosomal RNA Regulation
Argonaute proteins, guided by small RNAs, play crucial roles in gene regulation and genome protection through RNA interference (RNAi)-related mechanisms.
Shatskikh, Aleksei S +2 more
core +1 more source
Molecular Oncology, EarlyView.Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
SELEX with Affinity Chromatography on RNA-RNA Interaction
Journal of the Korean Chemical Society, 2015 RNA-RNA interaction is a feature of many biologicalprocesses including translation, post-transcriptional regu-lation, RNA interference and the action of ribozymes. Theinteraction between RNA and RNA can occur through nor-mal Watson-Crick interaction or specific tertiary interac-tion.
openaire +2 more sources
Study of regulatory models of RNA in RNA-protein phase separation condensation
四川大学学报. 自然科学版This modeling study aims to model the regulatory role of RNA in RNA-protein （PROT） phase separation condensation （PSC）. First， based on diffusion kinetics and Hill kinetics， a novel theoretical model for dynamic RNA-PROT PSC is proposed.
HAN Tuo-Di +3 more
doaj