Results 131 to 140 of about 867,422 (305)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

SELEX with Affinity Chromatography on RNA-RNA Interaction

Journal of the Korean Chemical Society, 2015
RNA-RNA interaction is a feature of many biologicalprocesses including translation, post-transcriptional regu-lation, RNA interference and the action of ribozymes. Theinteraction between RNA and RNA can occur through nor-mal Watson-Crick interaction or specific tertiary interac-tion.
openaire   +2 more sources

Nonstandard RNA/RNA interactions likely enhance folding and stability of segmented ribosomes. [PDF]

RNA, 2022
Rivas M, Fox GE.
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Evidence for a base-pairing interaction between U6 small nuclear RNA and 5' splice site during the splicing reaction in yeast.

, 1992
Hitoshi Sawa, John Abelson
openalex   +1 more source

Elucidating the Role of Noncovalent Interactions in Favipiravir, a Drug Active against Various Human RNA Viruses; a 1H-14N NQDR/Periodic DFT/QTAIM/RDS/3D Hirshfeld Surfaces Combined Study [PDF]

, 2023
Jolanta Natalia Latosińska, Magdalena Latosińska, J. Seliger, V. Žagar, T. Apih, Paweł Grieb   +5 more
openalex   +1 more source

Circular versus linear RNA topology: different modes of RNA-RNA interactions in vitro and in human cells. [PDF]

RNA Biol, 2021
Petkovic S, Graff S, Feller N, Berghaus J, Ruppert VP, Dülfer J, Sczakiel G.   +6 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Systematic identification of variant-specific RNA structure-small molecule interactions exemplified by RNA G-quadruplexes

Nature Communications
Individual genetic variations, such as cancer-associated somatic mutations, alter RNA structures, thereby potentially enhancing or inhibiting the binding of RNA-targeting small molecules. However, to date, no approach has been available to identify these
Emi Miyashita, Kazumitsu Onizuka, Yutong Chen, Hiroki Yoshida, Hina Hatayama, Shunya Ishikawa, Peijie Yan, Takahito Hasegawa, Mamiko Ozawa, Kaho Maeta, Fumi Nagatsugi, Hirohide Saito, Kaoru R. Komatsu   +12 more
doaj   +1 more source

Hold On! RNA polymerase interactions with the nascent RNA modulate transcription elongation and termination [PDF]

, 2010
Dina Grohmann, Finn Werner
openalex   +1 more source