Results 21 to 30 of about 867,422 (305)

RNA Proximity Labeling: A New Detection Tool for RNA–Protein Interactions

Molecules, 2021
Multiple cellular functions are controlled by the interaction of RNAs and proteins. Together with the RNAs they control, RNA interacting proteins form RNA protein complexes, which are considered to serve as the true regulatory units for post ...
Ronja Weissinger, Lisa Heinold, Saira Akram, Ralf-Peter Jansen, Orit Hermesh   +4 more
doaj   +1 more source

Hfq CLASH uncovers sRNA-target interaction networks linked to nutrient availability adaptation

eLife, 2020
By shaping gene expression profiles, small RNAs (sRNAs) enable bacteria to efficiently adapt to changes in their environment. To better understand how Escherichia coli acclimatizes to nutrient availability, we performed UV cross-linking, ligation and ...
Ira Alexandra Iosub, Robert Willem van Nues, Stuart William McKellar, Karen Jule Nieken, Marta Marchioretto, Brandon Sy, Jai Justin Tree, Gabriella Viero, Sander Granneman   +8 more
doaj   +1 more source

A Conserved Target Site in HIV-1 Gag RNA is Accessible to Inhibition by Both an HDV Ribozyme and a Short Hairpin RNA

Molecular Therapy: Nucleic Acids, 2014
Antisense-based molecules targeting HIV-1 RNA have the potential to be used as part of gene or drug therapy to treat HIV-1 infection. In this study, HIV-1 RNA was screened to identify more conserved and accessible target sites for ribozymes based on the ...
Robert J Scarborough, Michel V Lévesque, Etienne Boudrias-Dalle, Ian C Chute, Sylvanne M Daniels, Rodney J Ouellette, Jean-Pierre Perreault, Anne Gatignol   +7 more
doaj   +1 more source

Progress of CRISPR-Cas13 Mediated Live-Cell RNA Imaging and Detection of RNA-Protein Interactions

Frontiers in Cell and Developmental Biology, 2022
Ribonucleic acid (RNA) and proteins play critical roles in gene expression and regulation. The relevant study increases the understanding of various life processes and contributes to the diagnosis and treatment of different diseases.
Huake Cao, Huake Cao, Yuechen Wang, Yuechen Wang, Ning Zhang, Ning Zhang, Ning Zhang, Siyuan Xia, Siyuan Xia, Pengfei Tian, Pengfei Tian, Pengfei Tian, Li Lu, Juan Du, Juan Du, Yinan Du   +15 more
doaj   +1 more source

Global Mapping of Human RNA-RNA Interactions [PDF]

Molecular Cell, 2016
The majority of the human genome is transcribed into non-coding (nc)RNAs that lack known biological functions or else are only partially characterized. Numerous characterized ncRNAs function via base pairing with target RNA sequences to direct their biological activities, which include critical roles in RNA processing, modification, turnover, and ...
Eesha, Sharma, Tim, Sterne-Weiler, Dave, O'Hanlon, Benjamin J, Blencowe   +3 more
openaire   +2 more sources

Impact of Diminished Expression of circRNA on Multiple Sclerosis Pathomechanisms

Frontiers in Immunology, 2022
Circular RNA (circRNA) molecules represent a novel and unique class of endogenous non-coding RNAs controlling the expression and function of microRNA (miRNA) and post-transcriptional regulation.
Marcin P. Mycko, Anna E. Zurawska, Igor Selmaj, Krzysztof W. Selmaj, Krzysztof W. Selmaj   +4 more
doaj   +1 more source

RAID: a comprehensive resource for human RNA-associated (RNA–RNA/RNA–protein) interaction [PDF]

RNA, 2014
Transcriptomic analyses have revealed an unexpected complexity in the eukaryote transcriptome, which includes not only protein-coding transcripts but also an expanding catalog of noncoding RNAs (ncRNAs). Diverse coding and noncoding RNAs (ncRNAs) perform functions through interaction with each other in various cellular processes.
Zhang, Xiaomeng, Wu, Deng, Chen, Liqun, Li, Xiang, Yang, Jinxurong, Fan, Dandan, Dong, Tingting, Liu, Mingyue, Tan, Puwen, Xu, Jintian, Yi, Ying, Wang, Yuting, Zou, Hua, Hu, Yongfei, Fan, Kaili, Kang, Juanjuan, Huang, Yan, Miao, Zhengqiang, Bi, Miaoman, Jin, Nana, Li, Kongning, Li, Xia, Xu, Jianzhen, Wang, Dong   +23 more
openaire   +2 more sources

Virus-derived DNA drives mosquito vector tolerance to arboviral infection

Nature Communications, 2016
Mosquitoes tolerate long-lasting viral infections, which makes them efficient vectors for human viral diseases. Here, the authors show that the tolerance of Aedesmosquitoes to infection with dengue or chikungunya viruses depends on the production of ...
Bertsy Goic, Kenneth A. Stapleford, Lionel Frangeul, Aurélien J. Doucet, Valérie Gausson, Hervé Blanc, Nidia Schemmel-Jofre, Gael Cristofari, Louis Lambrechts, Marco Vignuzzi, Maria-Carla Saleh   +10 more
doaj   +1 more source

RNAplex: a fast tool for RNA–RNA interaction search [PDF]

Bioinformatics, 2008
Abstract Motivation: Regulatory RNAs often unfold their action via RNA-RNA interaction. Transcriptional gene silencing by means of siRNAs and miRNA as well as snoRNA directed RNA editing rely on this mechanism. Additionally ncRNA regulation in bacteria is mainly based upon RNA duplex formation.
Hakim Tafer, Ivo L. Hofacker
openaire   +3 more sources

Fast accessibility-based prediction of RNA–RNA interactions [PDF]

Bioinformatics, 2011
Abstract Motivation: Currently, the best RNA–RNA interaction prediction tools are based on approaches that consider both the inter- and intramolecular interactions of hybridizing RNAs. While accurate, these methods are too slow and memory-hungry to be employed in genome-wide RNA target scans. Alternative methods neglecting intramolecular
Hakim Tafer, Fabian Amman, Florian Eggenhofer, Peter F. Stadler, Ivo L. Hofacker   +4 more
openaire   +3 more sources