Results 71 to 80 of about 4,240,750 (265)

Simultaneous Capture of Chromatin-Associated RNA and Global RNA–RNA Interactions With Reduced Input Requirements

Bio-Protocol
Chromatin-associated RNAs (caRNAs) have been increasingly recognized as key regulators of gene expression and genome architecture. A few technologies, such as ChRD-PET and RedChIP, have emerged to assess protein-mediated RNA–chromatin interactions, but ...
Cheng Ding, Guoting Chen, Shiping Luan, Yuanyuan Gong, Cuilin Gui, Chen Yang, Zihe Xiang, Junjie Du, Mohamed Foda, Jiapei Yan, Xingwang Li   +10 more
doaj   +1 more source

Uncovering Novel Viral Innate Immune Evasion Strategies: What Has SARS-CoV-2 Taught Us?

Frontiers in Microbiology, 2022
The ongoing SARS-CoV-2 pandemic has tested the capabilities of public health and scientific community. Since the dawn of the twenty-first century, viruses have caused several outbreaks, with coronaviruses being responsible for 2: SARS-CoV in 2007 and ...
Douglas Jie Wen Tay, Douglas Jie Wen Tay, Douglas Jie Wen Tay, Zhe Zhang Ryan Lew, Zhe Zhang Ryan Lew, Justin Jang Hann Chu, Justin Jang Hann Chu, Justin Jang Hann Chu, Justin Jang Hann Chu, Kai Sen Tan, Kai Sen Tan, Kai Sen Tan, Kai Sen Tan   +12 more
doaj   +1 more source

Benchmarking the methods for predicting base pairs in RNA-RNA interactions [PDF]

MOTIVATION: The intricate network of RNA-RNA interactions, crucial for orchestrating essential cellular processes like transcriptional and translational regulations, has been unveiling through high-throughput techniques and computational predictions.
Lang, Mei, Zhan, Jian, Zhou, Yaoqi, Litfin, Thomas, Chen, Ke   +4 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

A comprehensive comparison of general RNA–RNA interaction prediction methods [PDF]

Nucleic Acids Research, 2015
RNA-RNA interactions are fast emerging as a major functional component in many newly discovered non-coding RNAs. Basepairing is believed to be a major contributor to the stability of these intermolecular interactions, much like intramolecular basepairs formed in RNA secondary structure.
Lai, D., Meyer, I.M.
openaire   +2 more sources

Mapping of Influenza Virus RNA-RNA Interactions Reveals a Flexible Network

Cell Reports, 2020
Summary: Selective assembly of influenza virus segments into virions is proposed to be mediated through intersegmental RNA-RNA interactions. Here, we developed a method called 2CIMPL that includes proximity ligation under native conditions to identify ...
Valerie Le Sage, Jack P. Kanarek, Dan J. Snyder, Vaughn S. Cooper, Seema S. Lakdawala, Nara Lee   +5 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

RNA–RNA interaction prediction based on multiple sequence alignments [PDF]

Bioinformatics, 2010
Abstract Motivation: Many computerized methods for RNA–RNA interaction structure prediction have been developed. Recently, O(N6) time and O(N4) space dynamic programming algorithms have become available that compute the partition function of RNA–RNA interaction complexes. However, few of these methods incorporate the knowledge concerning
Andrew X. Li, Manja Marz, Jing Qin 0006, Christian M. Reidys   +3 more
openaire   +4 more sources

Polygenic viral factors enable efficient mosquito-borne transmission of African Zika virus

Nature Communications
Zika virus (ZIKV) is a mosquito-borne orthoflavivirus primarily transmitted among humans by Aedes aegypti. Over the past two decades, it has caused significant outbreaks associated with birth defects and neurological disorders.
Shiho Torii, Jennifer S. Lord, Morgane Lavina, Matthieu Prot, Alicia Lecuyer, Cheikh T. Diagne, Oumar Faye, Ousmane Faye, Amadou A. Sall, Michael B. Bonsall, Etienne Simon-Lorière, Xavier Montagutelli, Louis Lambrechts   +12 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source