Results 211 to 220 of about 582,722 (350)
In pancreatic cancer, the protein DKK3 is found to play a complex role: it initially slows early tumor growth but later promotes tumor aggressiveness. DKK3 expression evolves during progression and drives cancer severity by orchestrating cellular and molecular signaling pathways.
Dharini Srinivasan +20 more
wiley +1 more source
IPScan: Detecting novel intronic PolyAdenylation events with RNA-seq data. [PDF]
Fahmi NA +5 more
europepmc +1 more source
RNA sequencing is a method for transcriptome analysis. Understanding the transcriptome is essential for various reasons such as interpreting the functional elements of the genome and undrestanding development of diseases, among many other use cases. This thesis presents a new RNA-seq spliced alignment algorithm, that uses finding the longest increasing
openaire +1 more source
Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids
Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang +6 more
wiley +1 more source
Expression changes in Fasl-deficient calvaria-derived osteoblasts: an RNA-seq analysis. [PDF]
Kratochvilova A +5 more
europepmc +1 more source
This study investigates a schematic overview of the mechanistic pathways. The relationship between myopia and DR has long been of clinical interest. In diabetic mice, Nna1 expression is downregulated, whereas in diabetic mice with FDM, Nna1 expression is upregulated–particularly in Müller cells–accompanied by decreased vascular endothelial growth ...
Lihui Xie +5 more
wiley +1 more source
MntJULiP and Jutils: differential splicing analysis of RNA-seq data with covariates. [PDF]
Lui WW, Yang G, He Z, Florea L.
europepmc +1 more source

