Results 51 to 60 of about 567,059 (348)
COEX-Seq: Convert a Variety of Measurements of Gene Expression in RNA-Seq [PDF]
Genomics & Informatics, 2018 Next generation sequencing (NGS), a high-throughput DNA sequencing technology, is widely used for molecular biological studies. In NGS, RNA-sequencing (RNA-Seq), which is a short-read massively parallel sequencing, is a major quantitative transcriptome ...
Sang Cheol Kim +2 more
doaj +1 more source
Comparison of reproducibility, accuracy, sensitivity, and specificity of miRNA quantification platforms [PDF]
, 2019 Given the increasing interest in their use as disease biomarkers, the establishment of reproducible, accurate, sensitive, and specific platforms for microRNA (miRNA) quantification in biofluids is of high priority.
Barczak, Andrea J +8 more
core +1 more source
FEBS Letters, EarlyView.Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona +4 more
wiley +1 more source
PLoS ONE, 2019 The wealth of information deliverable from transcriptome sequencing (RNA-seq) is significant, however current applications for variant detection still remain a challenge due to the complexity of the transcriptome.
Modupeore O Adetunji +3 more
doaj +1 more source
FEBS Letters, EarlyView.Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello +6 more
wiley +1 more source
Probe Region Expression Estimation for RNA-Seq Data for Improved Microarray Comparability. [PDF]
PLoS ONE, 2015 Rapidly growing public gene expression databases contain a wealth of data for building an unprecedentedly detailed picture of human biology and disease.
Karolis Uziela, Antti Honkela
doaj +1 more source
Near-optimal RNA-Seq quantification [PDF]
, 2015 We present a novel approach to RNA-Seq quantification that is near optimal in speed and accuracy. Software implementing the approach, called kallisto, can be used to analyze 30 million unaligned paired-end RNA-Seq reads in less than 5 minutes on a ...
Bray, Nicolas +3 more
core +1 more source
Simultaneous generation of many RNA-seq libraries in a single reaction [PDF]
, 2015 Although RNA-seq is a powerful tool, the considerable time and cost associated with library construction has limited its utilization for various applications.
Bhattacharyya, Roby P. +15 more
core +1 more source
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
wiley +1 more source
Polyribosomal RNA-Seq reveals the decreased complexity and diversity of the Arabidopsis translatome.
PLoS ONE, 2015 Recent RNA-seq studies reveal that the transcriptomes in animals and plants are more complex than previously thought, leading to the inclusion of many more splice isoforms in annotated genomes. However, it is possible that a significant proportion of the
Xingtan Zhang +4 more
doaj +1 more source