GSVA: gene set variation analysis for microarray and RNA-Seq data
BMC Bioinformatics, 2013 Gene set enrichment (GSE) analysis is a popular framework for condensing information from gene expression profiles into a pathway or signature summary.
Sonja Hänzelmann +2 more
semanticscholar +1 more source
CHIMIA, 2021 Nervous system disorders affect millions of people around the world, through a very broad range of diseases. Here we describe our contribution to find a treatment for patients suffering from three of those diseases.
Hasane Ratni
doaj +1 more source
Identification of mechanics-responsive osteocyte signature in osteoarthritis subchondral bone
Bone & Joint Research, 2022 Aims: Osteoarthritis (OA) is a common degenerative joint disease. The osteocyte transcriptome is highly relevant to osteocyte biology. This study aimed to explore the osteocyte transcriptome in subchondral bone affected by OA.
Jun Zhou +7 more
doaj +1 more source
Effects of zinc oxide nanoparticles on the expression of zinc transporter 1-4 genes in the hippocampus of male rats under acute stress [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2021 Zinc transporters (ZnT) and ZIP proteins maintain Zinc homeostasis in the live organisms. On the other hand, the impacts of zinc oxide nanoparticles (ZnO NPs) on the expression of the Znt genes in biological systems were not clear yet.
Maede NILECHI +3 more
doaj +1 more source
voom: precision weights unlock linear model analysis tools for RNA-seq read counts
Genome Biology, 2014 New normal linear modeling strategies are presented for analyzing read counts from RNA-seq experiments. The voom method estimates the mean-variance relationship of the log-counts, generates a precision weight for each observation and enters these into ...
C. Law, Yunshun Chen, Wei Shi, G. Smyth
semanticscholar +1 more source
On the utility of RNA sample pooling to optimize cost and statistical power in RNA sequencing experiments [PDF]
, 2020 Background: In gene expression studies, RNA sample pooling is sometimes considered because of budget constraints or lack of sufficient input material. Using microarray technology, RNA sample pooling strategies have been reported to optimize both the cost
Assefa, Alemu Takele +2 more
core +2 more sources
Recognition of two distinct elements in the RNA substrate by the RNA-binding domain of the T. thermophilus DEAD box helicase Hera [PDF]
, 2013 DEAD box helicases catalyze the ATP-dependent destabilization of RNA duplexes. Whereas duplex separation is mediated by the helicase core shared by all members of the family, flanking domains often contribute to binding of the RNA substrate.
Klostermeier, Dagmar +5 more
core +1 more source
RNA-Binding protein HuR and the members of miR-200 family play an unconventional role in the regulation of c-Jun mRNA [PDF]
, 2016 Post-transcriptional gene regulation is a fundamental step for coordinating cellular response in a variety of processes. RNA-binding proteins (RBPs) and microRNAs (miRNAs) are the most important factors responsible for this regulation.
BOZZONI, Irene +6 more
core +1 more source
HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs [PDF]
, 2019 HuR/ELAVL1 is an RNA-binding protein involved in differentiation and stress response that acts primarily by stabilizing messenger RNA (mRNA) targets. HuR comprises three RNA recognition motifs (RRMs) where the structure and RNA binding of RRM3 and of ...
Asami S +4 more
core +1 more source
Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA
Journal of Visualized Experiments, 2021 The growing role attributed nowadays to long non-coding RNAs (lncRNA) in physiology and pathophysiology makes it crucial to characterize their interactome by identifying their molecular partners, DNA, proteins and/or RNAs. The latter can interact with lncRNA through networks involving proteins, but they can also be engaged in direct RNA/RNA ...
Jacq, Audrey +6 more
openaire +4 more sources