Results 41 to 50 of about 4,315,290 (339)

RNA helicases in RNA decay [PDF]

Biochemical Society Transactions, 2018
RNA molecules have the tendency to fold into complex structures or to associate with complementary RNAs that exoribonucleases have difficulties processing or degrading. Therefore, degradosomes in bacteria and organelles as well as exosomes in eukaryotes have teamed-up with RNA helicases.
Khemici, Vanessa, Linder, Patrick
openaire   +3 more sources

An improved method for surface immobilisation of RNA: application to small Non-Coding RNA - mRNA pairing [PDF]

, 2013
Characterisation of RNA and its intermolecular interactions is increasing in importance as the inventory of known RNA functions continues to expand. RNA-RNA interactions are central to post-transcriptional gene regulation mechanisms in bacteria, and the ...
Butt, Louise, Callaghan, Anastasia, Gowers, Darren, Henderson, Charlotte, Mardle, C., Phillips, Jack, Pickford, Andy, Roberts, Adam J., Stone, Carlanne, Vincent, H.   +9 more
core   +3 more sources

Investigation of HIV-1 Gag binding with RNAs and Lipids using Atomic Force Microscopy [PDF]

, 2019
Atomic Force Microscopy was utilized to study the morphology of Gag, {\Psi}RNA, and their binding complexes with lipids in a solution environment with 0.1{\AA} vertical and 1nm lateral resolution. TARpolyA RNA was used as a RNA control.
Chen, Shaolong, Gill, Sarjeet S., Liu, Mingyue, Mohideen, Umar, Rao, A. L. N., Xu, Jun, Zandi, Roya   +6 more
core   +3 more sources

Investigating therapeutic efficacy of dacarbazine and temozolomide, alone and in combination with BRAF(V600E) siRNA in A375 human melanoma cell line [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Melanoma is one of the most aggressive and deadly skin cancers. Despite advances, effective melanoma treatment is challenging, often requiring a shift from individual therapies to combination approaches.
Fatemeh Tabandeh, Rana Moradian Tehrani, Mohammadreza Sharifi, Elmira Toopchi   +3 more
doaj   +1 more source

RNA tectonics: towards RNA design

Folding and Design, 1996
Our understanding of the structural, folding and catalytic properties of RNA molecules has increased enormously in recent years. The discovery of catalytic RNA molecules by Sidney Altman and Tom Cech, the development of in vitro selection procedures, and the recent crystallizations of hammerhead ribozymes and of a large domain of an autocatalytic group
Westhof, Eric, Masquida, Benoît, Jaeger, Luc   +2 more
openaire   +2 more sources

Moving RNA moves RNA forward [PDF]

Science China Life Sciences, 2013
Cell communication affects all aspects of cell structure and behavior, such as cell proliferation, differentiation, division, and coordination of various physiological functions. The moving RNA in plants and mammalian cells indicates that nucleic acid could be one of the various types of messengers for cell communication. The microvesicle is a critical
Peng, LiNa, Li, YuJiao, Zhang, Lan, Yu, WenQiang   +3 more
openaire   +2 more sources

Estimate and determinants of SARS-CoV-2 RNA clearance time among non-severe COVID-19 patients

Journal of Family Medicine and Primary Care, 2022
Objectives: To estimate SARS-CoV-2 RNA clearance time among non-severe COVID-19 patients and explore factors associated with delayed negative conversion.
Mohammed A Aljunaid, Abdulrahman M Albeshry, Najim Z Alshahrani, Samaher S Barabie   +3 more
doaj   +1 more source

RNA-binding protein CPEB1 remodels host and viral RNA landscapes. [PDF]

, 2016
Host and virus interactions occurring at the post-transcriptional level are critical for infection but remain poorly understood. Here, we performed comprehensive transcriptome-wide analyses revealing that human cytomegalovirus (HCMV) infection results in
Aigner, Stefan, Ares, Manuel, Batra, Ranjan, Belzile, Jean-Philippe, Bos, Tomas J, Clark, Elizabeth, Donohue, John Paul, Gelboin-Burkhart, Chelsea, Huang, Hui, Huelga, Stephanie C, Rigo, Frank, Roberts, Brett T, Sathe, Shashank, Spector, Deborah H, Stark, Thomas J, Wheeler, Emily C, Yee, Brian A, Yeo, Gene W   +17 more
core   +2 more sources

RNA Chemistry for RNA Biology

CHIMIA, 2019
Advances in the chemical synthesis of RNA have opened new possibilities to address current questions in RNA biology. Access to site-specifically modified oligoribonucleotides is often a pre-requisite for RNA chemical-biology projects. Driven by the enormous research efforts for development of oligonucleotide therapeutics, a wide range of ...
Rothlisberger, Pascal, Berk, Christian, Hall, Jonathan   +2 more
openaire   +5 more sources

Micro-RNA-1 is decreased by hypoxia and contributes to the development of pulmonary vascular remodeling via regulation of sphingosine kinase 1 [PDF]

, 2018
Sphingosine kinase 1 (SphK1) upregulation is associated with pathologic pulmonary vascular remodeling in pulmonary arterial hypertension (PAH), but the mechanisms controlling its expression are undefined.
Chen, Jiwang, Comhair, Suzy, Machado, Roberto F., Natarajan, Viswanathan, Singla, Sunit, Sysol, Justin R., Zhao, Shuangping   +6 more
core   +1 more source