Results 121 to 130 of about 1,370,770 (219)

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Development of CAR T Cells Targeting a Surface RNA-Binding Protein for the Treatment of Acute Leukemias. [PDF]

Cancer Discov
Fujino T, Lewis J, Chen B, Feinberg TY, Maron MI, Lewis AM, Wishnack C, Sievers Q, Kaito S, Cai W, Yoo S, Mathew SC, Souness S, Burns E, Um J, de Stanchina E, Chang Q, Qeriqi B, Chen K, Zhang P, DeWolf S, Weinreb JT, Mammone R, Miranda IC, Stanley RF, Cuibus MA, Weis K, Gipson B, Castro C, Fox N, Lee MS, Alvarez-Perez J, You D, Dela Cruz FS, Fronk AD, Akerman M, Kung AL, Abdel-Wahab O, Daniyan AF.   +38 more
europepmc   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

RNA-Binding Protein Trim71 Controls Epicardial Cell Migration. [PDF]

J Cardiovasc Dev Dis
Castillo-Casas JM, García-Padilla C, Carmona R, Lozano-Velasco E, Franco D.   +4 more
europepmc   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

The RNA-binding protein HuR stabilizes survivin mRNA in human oesophageal epithelial cells. [PDF]

Biochem J
Donahue JM, Chang ET, Xiao L, Wang PY, Rao JN, Turner DJ, Wang JY, Battafarano RJ.   +7 more
europepmc   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Expression and Role of the RNA-Binding Protein, ZFP36L1, in Mouse T Follicular Helper Cell Differentiation and Function. [PDF]

Eur J Immunol
Carslaw HA, Woolliscroft S, Watson EM, Bell SE, Linterman MA, Turner M, Webb LMC.   +6 more
europepmc   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

The RNA-binding protein Pumilio limits polymodal nociception in <i>Drosophila</i> larvae. [PDF]

PeerJ
Palega S, Davenport H, Stewart RK, Horton J, Bellemer A.   +4 more
europepmc   +1 more source