Results 231 to 240 of about 1,873,837 (361)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

RNA binding protein Sam68 promotes germinal center reaction and IgG response through regulation of miR29. [PDF]

Cell Mol Life Sci
Datta M, Renna V, Kumar M, Maity PC, Jumaa H.   +4 more
europepmc   +1 more source

Characterization of the RNA binding proteins forming complexes with a novel putative regulatory region in the 3'-UTR of TNF-alpha mRNA

, 1998
Zdeněk Hel
openalex   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

RNA-binding protein Rbm38 as a multifaceted post-transcriptional regulator in zebrafish pancreatic development. [PDF]

J Mol Cell Biol
Zhang X, Li X, Liu R, Wang L, Wang Y, Zhang A, Yang S, Li H.   +7 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

RSRC2 is a novel RNA-binding protein that safeguards mitotic fidelity by interacting with the lncRNA C1QTNF1-AS1. [PDF]

Nucleic Acids Res
Babaei P, Coomer AO, Georgieva K, Guiducci G, Vitiello E, Dodel M, Maniati E, Eid HE, Thind A, Krishnamurthy S, Nawrocka A, Wallis S, Wang J, Shkumatava A, Mardakheh FK, Stojic L.   +15 more
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Zinc-dependent RNA-binding protein controls hepatocyte senescence and recovery from alcohol-related liver failure. [PDF]

Gut
Dutta RK, Du K, Ren N, Umbaugh DS, Oh SH, Wang L, Kalsotra A, Blackshear PJ, Diehl AM.   +8 more
europepmc   +1 more source

Author response: ASAR lncRNAs control DNA replication timing through interactions with multiple hnRNP/RNA binding proteins

Mathew J. Thayer, Michael B. Heskett, Leslie G. Smith, Paul T. Spellman, Phillip A. Yates   +4 more
openalex   +1 more source