Results 261 to 270 of about 134,303 (299)

Crystal structure of mouse DXO in complex with the UDP-N-acetylglucosamine cap and molecular mechanism for the decapping reactions. [PDF]

Nucleic Acids Res
Ullah N, Doamekpor SK, Tong L.
europepmc   +1 more source

5′-cap RNA/SAM mimetic conjugates as bisubstrate inhibitors of viral RNA cap 2′-O-methyltransferases

Bioorganic Chemistry
Viral RNA cap 2'-O-methyltransferases are considered promising therapeutic targets for antiviral treatments, as they play a key role in the formation of viral RNA cap-1 structures to escape the host immune system. A better understanding of how they interact with their natural substrates (RNA and the methyl donor SAM) would enable the rational ...
Rostom Ahmed-Belkacem, Priscila Sutto-Ortiz, Adrien Delpal   +2 more
exaly   +6 more sources

RNA methyltransferases involved in 5′ cap biosynthesis [PDF]

RNA Biology, 2014
In eukaryotes and viruses that infect them, the 5' end of mRNA molecules, and also many other functionally important RNAs, are modified to form a so-called cap structure that is important for interactions of these RNAs with many nuclear and cytoplasmic proteins.
Elżbieta Purta, Janusz M Bujnicki
exaly   +4 more sources

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NAD-capped RNAs – a redox cofactor meets RNA

Trends in Biochemical Sciences, 2023
RNA modifications immensely expand the diversity of the transcriptome, thereby influencing the function, localization, and stability of RNA. One prominent example of an RNA modification is the eukaryotic cap located at the 5' terminus of mRNAs. Interestingly, the redox cofactor NAD can be incorporated into RNA by RNA polymerase in vitro.
Maik Wolfram-Schauerte, Katharina Höfer
openaire   +3 more sources

If the 5’ cap fits (wear it) – Non-canonical RNA capping

RNA Biology
RNA capping is a prominent RNA modification that influences RNA stability, metabolism, and function. While it was long limited to the study of the most abundant eukaryotic canonical m7G cap, the field recently went through a large paradigm shift with the discovery of non-canonical RNA capping in bacteria and ultimately all domains of life.
Jiří František Potužník, Hana Cahova   +1 more
exaly   +5 more sources

Chemical Route to the Capped RNAs

Nucleosides, Nucleotides & Nucleic Acids, 2004
Eukaryotic and viral messenger RNAs contain a CAP structure that plays an important role in the initiation of translation and several other cellular processes that involve mRNAs. In this paper, we report a convenient chemical approach to the preparation of milligram quantities of short, capped RNA oligonucleotides, which overcomes some of the ...
I I, Koukhareva, A V, Lebedev
openaire   +2 more sources