Results 41 to 50 of about 134,303 (299)

Loss of Human TGS1 Hypermethylase Promotes Increased Telomerase RNA and Telomere Elongation

Cell Reports, 2020
Summary: Biogenesis of the human telomerase RNA (hTR) involves a complex series of posttranscriptional modifications, including hypermethylation of the 5′ mono-methylguanosine cap to a tri-methylguanosine cap (TMG). How the TMG cap affects hTR maturation
Lu Chen, Caitlin M. Roake, Alessandra Galati, Francesca Bavasso, Emanuela Micheli, Isabella Saggio, Stefan Schoeftner, Stefano Cacchione, Maurizio Gatti, Steven E. Artandi, Grazia D. Raffa   +10 more
doaj   +1 more source

Folding transitions during assembly of the eukaryotic mRNA cap-binding complex. [PDF]

, 2006
The cap-binding protein eIF4E is the first in a chain of translation initiation factors that recruit 40S ribosomal subunits to the 5' end of eukaryotic mRNA. During cap-dependent translation, this protein binds to the 5'-terminal m(7)Gppp cap of the mRNA,
von der Haar, Tobias, Ptushkina, Marina, Wagner, Gerhard, McCarthy, John E G, Moerke, Nathan, Oku, Yuko, McCarthy, John E. G., Mccarthy, John, Gross, John D.   +8 more
core   +1 more source

Identification, Biosynthesis, and Decapping of NAD-Capped RNAs in B. subtilis

Cell Reports, 2018
Summary: The ubiquitous coenzyme nicotinamide adenine dinucleotide (NAD) decorates various RNAs in different organisms. In the proteobacterium Escherichia coli, the NAD-cap confers stability against RNA degradation.
Jens Frindert, Yaqing Zhang, Gabriele Nübel, Masroor Kahloon, Leonie Kolmar, Agnes Hotz-Wagenblatt, Jürgen Burhenne, Walter E. Haefeli, Andres Jäschke   +8 more
doaj   +1 more source

A twist in the tail : SHAPE mapping of long-range interactions and structural rearrangements of RNA elements involved in HCV replication [PDF]

, 2011
The RNA structure and long-range interactions of the SL9266 cis-acting replication element located within the NS5B coding region of hepatitis C virus (HCV) were determined using selective 2′-hydroxyl acylation analysed by primer extension.
Tuplin, Andrew, Struthers, Madeleine, Struthers, M., Andrew Tuplin, Tuplin, A., Struthers, M, Madeleine Struthers, Simmonds, Peter, David J. Evans, Tuplin, A, Evans, DJ, Peter Simmonds, Evans, David J., Simmonds, P., Evans, D. J., Simmonds, P   +15 more
core   +1 more source

Anthralin Suppresses the Proliferation of Influenza Virus by Inhibiting the Cap-Binding and Endonuclease Activity of Viral RNA Polymerase

Frontiers in Microbiology, 2020
Influenza virus RNA-dependent RNA polymerase (vRdRp) does not have capping activity and relies on the capped RNAs produced by the host RNA polymerase II (RNAPII).
Ao Hu, Ao Hu, Jing Li, Wei Tang, Ge Liu, Ge Liu, Haiwei Zhang, Chunlan Liu, Xulin Chen, Xulin Chen, Xulin Chen   +10 more
doaj   +1 more source

Cap-independent translation of plant viral RNAs [PDF]

Virus Research, 2006
The RNAs of many plant viruses lack a 5' cap and must be translated by a cap-independent mechanism. Here, we discuss the remarkably diverse cap-independent translation elements that have been identified in members of the Potyviridae, Luteoviridae, and Tombusviridae families, and genus Tobamovirus.
Elizabeth L Pettit, Kneller, Aurélie M, Rakotondrafara, W Allen, Miller   +2 more
openaire   +2 more sources

The RRM domain of poly(A)-specific ribonuclease has a noncanonical binding site for mRNA cap analog recognition

, 2008
The degradation of the poly(A) tail is crucial for posttranscriptional gene regulation and for quality control of mRNA. Poly(A)-specific ribonuclease (PARN) is one of the major mammalian 3’ specific exo-ribonucleases involved in the degradation of the ...
Naohiro Kobayashi, Shirouzu, Mikako, Sakura Suzuki, Nagata, Takashi, Yoshihide Hayashizaki, Takashi Nagata, Yutaka Muto, Takanori Kigawa, Kobayashi, Naohiro, Peter Güntert, Mikako Shirouzu, Muto, Yutaka, Akiko Tanaka, Endo, Ryuta, Makoto Inoue, Hayashizaki, Yoshihide, Terada, Takaho, Inoue, Makoto, Kigawa, Takanori, Suzuki, Sakura, Yokoyama, Shigeyuki, Takaho Terada, Ryuta Endo, Shigeyuki Yokoyama, Güntert, Peter, Tanaka, Akiko   +25 more
core   +1 more source

A freeze frame view of vesicular stomatitis virus transcription defines a minimal length of RNA for 5' processing.

PLoS Pathogens, 2011
The RNA synthesis machinery of vesicular stomatitis virus (VSV) comprises the genomic RNA encapsidated by the viral nucleocapsid protein (N) and associated with the RNA dependent RNA polymerase, the viral components of which are a large protein (L) and ...
Gergely Tekes, Amal A Rahmeh, Sean P J Whelan   +2 more
doaj   +1 more source

Practical Synthesis of Cap‐4 RNA

ChemBioChem, 2019
AbstractEukaryotic mRNAs possess 5′ caps that are determinants for their function. A structural characteristic of 5′ caps is methylation, with this feature already present in early eukaryotes such as Trypanosoma. While the common cap‐0 (m7GpppN) shows a rather simple methylation pattern, the Trypanosoma cap‐4 displays seven distinguished additional ...
Josef Leiter, Dennis Reichert, Andrea Rentmeister, Ronald Micura   +3 more
openaire   +2 more sources

Four methods of preparing mRNA 5' end libraries using the Illumina sequencing platform. [PDF]

PLoS ONE, 2014
BACKGROUND: The 5' untranslated regions of mRNA play an important role in their translation. RESULTS: Here, we describe the development of four methods of profiling mRNA 5' ends using the Illumina sequencing platform; the first method utilizes SMART ...
Ryuji J Machida, Ya-Ying Lin
doaj   +1 more source