Results 21 to 30 of about 134,303 (299)
Interaction Network of Porcine Circovirus Type 3 and 4 Capsids with Host Proteins
Viruses, 2022 An extensive understanding of the interactions between host cellular and viral proteins provides clues for studying novel antiviral strategies. Porcine circovirus type 3 (PCV3) and type 4 (PCV4) have recently been identified as viruses that can ...
Jianwei Zhou +8 more
doaj +1 more source
RNA capping by mitochondrial and multi-subunit RNA polymerases [PDF]
Transcription, 2018 Recently, it was found that bacterial and eukaryotic transcripts are capped with cellular cofactors installed by their respective RNA polymerases (RNAPs) during transcription initiation. We now show that mitochondrial RNAP efficiently caps transcripts with ADP - containing cofactors.
Christina Julius +2 more
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Visualization of two architectures in class-II CAP-dependent transcription activation.
PLoS Biology, 2020 Transcription activation by cyclic AMP (cAMP) receptor protein (CAP) is the classic paradigm of transcription regulation in bacteria. CAP was suggested to activate transcription on class-II promoters via a recruitment and isomerization mechanism. However,
Wei Shi +4 more
doaj +1 more source
2'-O-methylation of the mRNA cap protects RNAs from decapping and degradation by DXO. [PDF]
PLoS ONE, 2018 The 5' RNA cap structure (m7GpppRNA) is a key feature of eukaryotic mRNAs with important roles in stability, splicing, polyadenylation, mRNA export, and translation.
Frédéric Picard-Jean +11 more
doaj +1 more source
Molecular basis of specific viral RNA recognition and 5′-end capping by the Chikungunya virus nsP1
Cell Reports, 2022 Summary: Many viruses encode RNA-modifying enzymes to edit the 5′ end of viral RNA to mimic the cellular mRNA for effective protein translation, genome replication, and evasion of the host defense mechanisms.
Kuo Zhang +7 more
doaj +1 more source
Crystal structure of Schmallenberg orthobunyavirus nucleoprotein-RNA complex reveals a novel RNA sequestration mechanism [PDF]
, 2013 Schmallenberg virus (SBV) is a newly emerged orthobunyavirus (family Bunyaviridae) that has caused severe disease in the offspring of farm animals across Europe.
Richard M. Elliott +16 more
core +1 more source
Helix Capping in RNA Structure
PLoS ONE, 2014 Helices are an essential element in defining the three-dimensional architecture of structured RNAs. While internal basepairs in a canonical helix stack on both sides, the ends of the helix stack on only one side and are exposed to the loop side, thus susceptible to fraying unless they are protected.
Lee, Jung C., Gutell, Robin R.
openaire +5 more sources
RNA-specific ribonucleotidyl transferases [PDF]
, 2007 RNA-specific nucleotidyl transferases (rNTrs) are a diverse family of template-independent polymerases that add ribonucleotides to the 3'-ends of RNA molecules.
Keller, W. +3 more
core +1 more source
RAM function is dependent on Kapβ2-mediated nuclear entry [PDF]
, 2014 Eukaryotic gene expression is dependent on the modification of the first transcribed nucleotide of pre-mRNA by the addition of the 7-methylguanosine cap.
Gonatopoulos-Pournatzis, Thomas +1 more
core +1 more source
RNA capping: progress and prospects [PDF]
RNA, 2015 The 5′ m7GpppN cap, co-discovered by Shatkin, Furuichi, and Moss in 1975, is the signature feature of eukaryal cellular and viral messenger RNA that confers mRNA stability and efficient translation. Cap formation entails three sequential enzymatic modifications targeted to nascent pre-mRNAs synthesized by cellular or viral RNA polymerases. First, the 5′
openaire +2 more sources