Results 31 to 40 of about 134,303 (299)
Profiling stress-triggered RNA condensation with photocatalytic proximity labeling
Nature Communications, 2023 Stress granules (SGs) are highly dynamic cytoplasmic membrane-less organelles that assemble when cells are challenged by stress. RNA molecules are sorted into SGs where they play important roles in maintaining the structural stability of SGs and ...
Ziqi Ren, Wei Tang, Luxin Peng, Peng Zou
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Structural basis and dynamics of Chikungunya alphavirus RNA capping by nsP1 capping pores
Proceedings of the National Academy of Sciences, 2022 Alphaviruses are emerging positive-stranded RNA viruses which replicate and transcribe their genomes in membranous organelles formed in the cell cytoplasm. The nonstructural protein 1 (nsP1) is responsible for viral RNA capping and gates the replication organelles by assembling into monotopic membrane-associated dodecameric pores ...
Jones, Rhian +5 more
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PLoS Pathogens, 2021 Respiratory syncytial virus (RSV) is a negative sense single-stranded RNA virus and one of the main causes of severe lower respiratory tract infections in infants and young children.
Priscila Sutto-Ortiz +12 more
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Sequestering the 5′‐cap for viral RNA packaging
BioEssays, 2022 AbstractMany viruses evolved mechanisms for capping the 5′‐ends of their plus‐strand RNAs as a means of hijacking the eukaryotic messenger RNA (mRNA) splicing/translation machinery. Although capping is critical for replication, the RNAs of these viruses have other essential functions including their requirement to be packaged as either genomes or pre ...
Pengfei Ding, Michael F. Summers
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Biological roles of DExH RNA helicase, RHAU [PDF]
, 2007 In this thesis, I have described the work carried out on a single protein called RHAU, dealing with aspects of protein localization in cells, the regulation of global gene expression by different mechanisms, and cellular stress-responses.
Iwamoto, Fumiko
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5' cap-independent translation of dengue virus genomic RNA
Revista Peruana de Medicina Experimental y Salud Pública, 2015 Objetives. To analyze the involvement of methyl guanosine triphosphate cap (5’cap) and the start site of the genomic RNA of Dengue virus serotype 2 (DENV-2) American genotype in translation, using a cell-free system prepared from human placenta ...
Mariela Pérez Dominguez +5 more
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Anomalous HIV-1 RNA, How Cap-Methylation Segregates Viral Transcripts by Form and Function
Viruses, 2022 The acquisition of m7G-cap-binding proteins is now recognized as a major variable driving the form and function of host RNAs. This manuscript compares the 5′-cap-RNA binding proteins that engage HIV-1 precursor RNAs, host mRNAs, small nuclear (sn)- and ...
Kathleen Boris-Lawrie +5 more
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The SARS-CoV-2 RNA polymerase is a viral RNA capping enzyme [PDF]
Nucleic Acids Research, 2021 Abstract SARS-CoV-2 is a positive-sense RNA virus responsible for the Coronavirus Disease 2019 (COVID-19) pandemic, which continues to cause significant morbidity, mortality and economic strain. SARS-CoV-2 can cause severe respiratory disease and death in humans, highlighting the need for effective antiviral therapies.
Walker, AP +5 more
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Generation and characterization of a recombinant Rift Valley fever virus expressing a V5 epitope-tagged RNA-dependent RNA polymerase [PDF]
, 2011 The viral RNA-dependent RNA polymerase (RdRp; L protein) of Rift Valley fever virus (RVFV; family Bunyaviridae) is a 238 kDa protein that is crucial for the life cycle of the virus, as it catalyses both transcription of viral mRNAs and replication of the
Brennan, Benjamin +5 more
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Frontiers in Plant Science, 2018 In eukaryotes, the formation of a 5′-cap and 3′-poly(A) dependent protein–protein bridge is required for translation of its mRNAs. In contrast, several plant virus RNA genomes lack both of these mRNA features, but instead have a 3′-CITE (for cap ...
Manuel Miras +7 more
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