Results 121 to 130 of about 92,611 (279)

RNA chaperone activity of L1 ribosomal proteins: Phylogenetic conservation and splicing inhibition

, 2007
RNA chaperone activity is defined as the ability of proteins to either prevent RNA from misfolding or to open up misfolded RNA conformations. One-third of all large ribosomal subunit proteins from E.
Shcherbakov, Dmitry Yu (Medizinische Universität Innsbruck), Semrad, Katharina (Department of Biochemistry and Cell Biology, Centre for Molecular Biology, University of Vienna), Piendl, Wolfgang (Medizinische Universität Innsbruck), Nikonova, Ekaterina Yu (Institute of Protein Research), Ameres, Stefan (Department of Biochemistry and Cell Biology, Centre for Molecular Biology, University of Vienna), Schroeder, Renée (Department of Biochemistry and Cell Biology, Centre for Molecular Biology, University of Vienna)   +5 more
core   +1 more source

Palmitic Acid Promotes Antiviral Innate Immunity via ZDHHC20‐Mediated CMPK2 Palmitoylation

Advanced Science, EarlyView.
Metabolites have important functions in innate immune activation and regulation. Wang et al. uncover metabolic regulation of antiviral immunity through CMPK2 palmitoylation, which regulates CMPK2 mitochondrial localization and is promoted by ZDHHC20 but reversed by PPT1, inhibition of which antagonizes viral infection in mice.
Yujia Wang, Zenghui Cui, Yunkai Zhang, Zhiqing Li, Xuetao Cao   +4 more
wiley   +1 more source

NET‐DNA Activates the ANXA2/TMEM215/BiP Axis to Promote Mitophagy‐Mediated Anoikis Resistance in Endometriosis

Advanced Science, EarlyView.
NET‐DNA is enriched during early endometriotic lesion establishment and drives anoikis resistance by promoting an ANXA2–TMEM215–BiP axis. This pathway strengthens ER–mitochondria contacts, enhances PINK1/Parkin‐associated mitophagy, preserves mitochondrial homeostasis, and supports ectopic stromal cell survival, thereby facilitating lesion persistence ...
Honglin Wang, Yanling Gou, Huiyan Zhang, Hongli Wang, Beidi Wang, Jinming Liu, Yingying Cao, Ruru Bai, Yuxin Zhao, Xu Han, Chao Feng, Xin Huang, Zongfeng Zhang   +12 more
wiley   +1 more source

Taming free energy landscapes with RNA chaperones [PDF]

RNA Biology, 2010
Many non-coding RNAs fold into complex three-dimensional structures, yet the self-assembly of RNA structure is hampered by mispairing, weak tertiary interactions, electrostatic barriers, and the frequent requirement that the 5' and 3' ends of the transcript interact.
openaire   +2 more sources

Xp54 and related (DDX6-like) RNA helicases : roles in messenger RNP assembly, translation regulation and RNA degradation

, 2006
The DEAD-box RNA helicase Xp54 is an integral component of the messenger ribonucleoprotein (mRNP) particles of Xenopus oocytes. In oocytes, several abundant proteins bind pre-mRNA transcripts to modulate nuclear export, RNA stability and translational ...
Weston, A, Sommerville, John
core   +1 more source

Drug‐Induced Cuproptosis Defines the Therapeutic Window of Celecoxib in Intervertebral Disc Degeneration via the HSP90‐RBX1 Axis

Advanced Science, EarlyView.
This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo, Hongju Xiao, Shenghao Ba, Yu Zhou, Bijun Wang, Bin Yu, Yufeng Huang, Haihong Zhao, Zhefan Stephen Chen, Na Shen, Zhaoyu Ba, Desheng Wu   +11 more
wiley   +1 more source

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah   +17 more
wiley   +1 more source

RNA Chaperone Activity of the RRM2 Domain of Human La [PDF]

, 2015
Genuine La proteins are abundant RNA binding factors that primarily facilitate maturation of nascent precursor RNAs in eukaryotes. Chaperone activity is a conserved feature in the La superfamily, yet the structural basis for this activity remains obscure.
Sharifi, Samel
core  

Solution structure of the SGTA dimerisation domain and investigation of its interactions with the ubiquitin-like domains of BAG6 and UBL4A [PDF]

, 2014
Background The BAG6 complex resides in the cytosol and acts as a sorting point to target diverse hydrophobic protein substrates along their appropriate paths, including proteasomal degradation and ER membrane insertion.
Ewelina M Krysztofinska, Krysztofinska, EM, Darby, John F., Arjun Thapaliya, Maria R. Conte (664444), Isaacson Rivka L., Alfano, C, Bishop, David S., Peter J. Simpson (247964), Santiago Martínez-Lumbreras (206438), Conte, Maria R., Martinez-Lumbreras, S, High, S, Newran Sriskandarajah (664440), Leznicki, P, Rivka L. Isaacson (393277), Aline C Simon, Leznicki Pawel, Conte, Maria R; id_orcid, Thapaliya, Arjun, Caterina Alfano, Conte Maria R., Hale, Lisa R, High, Stephen; id_orcid, Simpson, PJ, Caterina Alfano (664443), Hale, Lisa R., Hale Lisa R., Pawel Leznicki (393272), Krysztofinska, Ewelina M, Simon, Aline C, Martínez-Lumbreras, Santiago, Newran Sriskandarajah, Sriskandarajah Newran, Bishop David S., Isaacson, Rivka L, Sriskandarajah, N, Aline C. Simon (664439), Ewelina M. Krysztofinska (393276), Bishop, DS, Simpson Peter J., Maria R Conte, Simpson, Peter J, Leznicki, Pawel, Darby, JF, John F. Darby (664438), David S. Bishop (664441), Thapaliya, A, Alfano Caterina, Hale, LR, Stephen High (20210), Peter J Simpson, Thapaliya Arjun, Conte, Maria R, Stephen High, Isaacson, RL, Arjun Thapaliya (664445), Krysztofinska Ewelina M., Martínez-Lumbreras Santiago, High Stephen, Darby John F., Lisa R Hale, Isaacson, Rivka L; id_orcid, John F Darby, Rivka L Isaacson, Lisa R. Hale (664442), Isaacson, Rivka L., Conte, MR, Simon Aline C., Darby, John F, Pawel Leznicki, Simon, AC, Simon, Aline C., David S Bishop, Santiago Martínez-Lumbreras, Krysztofinska, Ewelina M., Sriskandarajah, Newran, Bishop, David S, High, Stephen, Simpson, Peter J., Alfano, Caterina   +80 more
core   +1 more source

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source