Results 111 to 120 of about 2,163,835 (311)
444 Post-translational role of RNA modifications in sRNA chaperone Hfq
Journal of Clinical and Translational Science, 2022 OBJECTIVES/GOALS: The goal of this study is to determine the role of the tRNA modifications in the translation of Hfq. Hfq is an RNA chaperone that acts as a co-factor for the action of the largest class of small RNAs in E. coli.
Jalisa Nurse +2 more
doaj +1 more source
RNA Catalytic Activity as a Probe of Chaperone-Mediated RNA Folding [PDF]
, 2013 For structured RNAs that possess catalytic activity, this activity provides a powerful probe for measuring the progress of folding and the effects of RNA chaperone proteins on the folding rate. The crux of this approach is that only the natively folded RNA is able to perform the catalytic reaction.
Brant, Gracia, Rick, Russell
openaire +2 more sources
DEAD‐box proteins as RNA helicases and chaperones [PDF]
WIREs RNA, 2010 AbstractDEAD‐box proteins are ubiquitous in RNA‐mediated processes and function by coupling cycles of ATP binding and hydrolysis to changes in affinity for single‐stranded RNA. Many DEAD‐box proteins use this basic mechanism as the foundation for a version of RNA helicase activity, efficiently separating the strands of short RNA duplexes in a process ...
Inga, Jarmoskaite, Rick, Russell
openaire +2 more sources
Adenosine triphosphate as a modulator of protein interactions and stability
FEBS Open Bio, EarlyView.ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley +1 more source
Nature Communications, 2020 Long noncoding RNA SAM (Sugt1 associated muscle) is upregulated in the proliferating myoblast cells. Here the authors investigate SAM knockout mice and suggest that SAM binds and stabilizes Sugt1, a co-chaperone protein that regulates kinetochore ...
Yuying Li +10 more
doaj +1 more source
Formamide significantly enhances the efficiency of chemical adenylation of RNA sequencing ligation adaptors [PDF]
, 2023 Preadenylated single-stranded DNA ligation adaptors are essential reagents in many next generation RNA sequencing library preparation protocols. These oligonucleotides can be adenylated enzymatically or chemically.
Watts, Jonathan K +4 more
core +1 more source
FEBS Open Bio, EarlyView.Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada +7 more
wiley +1 more source
RNA remodeling by chaperones and helicases [PDF]
RNA Biology, 2010 (2010). RNA remodeling by chaperones and helicases. RNA Biology: Vol. 7, No. 6, pp. 632-633.
openaire +1 more source
On the facultative requirement of the bacterial RNA chaperone, Hfq [PDF]
Trends in Microbiology, 2009 The pleiotropic post-transcriptional regulator Hfq is an RNA chaperone that facilitates pairing interactions between small regulatory RNAs (sRNAs) and their mRNA targets in several bacteria. However, this classical pattern, derived from the Escherichia coli model, is not applicable to the whole bacterial kingdom.
Jousselin, Ambre +2 more
openaire +3 more sources
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source