Results 131 to 140 of about 92,611 (279)

Bakteri ribosoomide uurimus keemilise modifitseerimise meetoditega [PDF]

, 2010
Väitekirja elektrooniline versioon ei sisalda publikatsioone.Ribosoom on suur makromolekulaarne kompleks, mis kodeerib päriliku informatsiooni valgulisse olemusse.
Pulk, Arto
core  

SIRT6‐Mediated Deacetylation of ATF3 Promotes Silica‐Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α

Advanced Science, EarlyView.
SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng, Wenxia Bu, Fengxu Wang, Yueyuan Jin, Rongzhu Liu, Rui Zhao, Xuehai Wang, Mengna Jiang, Jinping Shen, Xinhang Cheng, Zuming Chen, Li Zhu, Jinlong Li, Zhenzhong Ge, Shichen Miao, Haotian Xu, Xiaoyu Zhou, Dongming Wang, Xinyuan Zhao   +18 more
wiley   +1 more source

The RNA binding and RNA chaperone activity of Sin Nombre virus nucleocapsid

, 2008
Sin Nombre Virus (SNV) is a member of the hantavirus genus in the Bunyaviridae family. Hantaviruses contain a tripartite negative sense RNA genome with individual segments that form panhandle structures through intramolecular interaction between the 5 ...
Brown, Bradley
core   +1 more source

RNA compaction and iterative scanning for small RNA targets by the Hfq chaperone

Nature Communications
RNA-guided enzymes must quickly search a vast sequence space for their targets. This search is aided by chaperones such as Hfq, a protein that mediates regulation by bacterial small RNAs (sRNAs).
Ewelina M. Małecka, Sarah A. Woodson
doaj   +1 more source

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, EarlyView.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source

Towards Understanding Helicase and Chaperone Activities in the RNA Degradosome

, 2020
The E. coli RNA degradosome is a complex multi-enzyme machine which is central to the post-transcriptional regulation of the cell. Some of its functions include maturing and processing sRNA, rRNA, and tRNA, as well as degrading mRNA.

core   +1 more source

CCT2 Promotes Prostate Cancer Progression Through EIF3F‐Dependent Stabilization of FASN

Advanced Science, EarlyView.
ABSTRACT Prostate cancer (PCa) is increasingly recognized to be driven by dysregulated lipid metabolism. Although fatty acid synthase (FASN) is highly expressed in PCa, the mechanisms governing FASN protein stability and its functional integration into oncogenic lipid metabolism remain poorly defined.
Shun Xu, Yifan Zhang, Haolin Li, Shengyu Zhao, Xiaoran Dai, Qili Xu, Mintian Fei, Chun Li, Zhihui Zou, Baojun Wang, Li Zhang, Hui Wang, Ligang Zhang, Chaozhao Liang   +13 more
wiley   +1 more source

The RNA chaperon activity of the human La protein (LARP3): DOI: 10.14800/rd.872

, 2016
Single-stranded RNA molecules fold intensively into secondary and tertiary structures and are often trapped in non-functional configurations. To adapt a functional configuration, structural changes have to be achieved.
Gunhild Sommer, Avery W Zierk, Alena Fedarovich, Alexander Brock, Dzmitry Fedarovich, Tilman Heise
core  

RNA-dependent proteome solubility maintenance in Escherichia coli lysates analysed by quantitative mass spectrometry: Proteomic characterization in terms of isoelectric point, structural disorder, functional hub, and chaperone network

Protein aggregation, a consequence of misfolding and impaired proteostasis, can lead to cellular malfunctions such as various proteinopathies.
Kwang Pyo Kim (600067), Yura Choi (554078), Yoontae Jin (17976878), Chan Park (114760), Baik L. Seong (17976884), Bitnara Han (17976875), Seong Il Choi (17976881)   +6 more
core   +1 more source

Mapping the RNA Chaperone Activity of the T. brucei Editosome Using SHAPE Chemical Probing

, 2019
Mitochondrial pre-mRNAs in African trypanosomes adopt intricately folded, highly stable 2D and 3D structures. The RNA molecules are substrates of a U-nucleotide-specific insertion/deletion-type RNA editing reaction, which is catalyzed by a 0.8 MDa ...
Leeder, W.-Matthias, Göringer, H. Ulrich, H. Ulrich Göringer, W.-Matthias Leeder   +3 more
core   +1 more source