Results 251 to 260 of about 1,834,577 (295)

Enediyne-mediated cleavage of RNA

Bioorganic & Medicinal Chemistry, 1995
RNA cleavage by enediyne anticancer antibiotics was shown to occur with no apparent sequence selectivity, but RNA structure appears to be important in those substrates where cleavage was observed. Neocarzinostatin (NCS) cleaved a wider variety of RNA substrates than either esperamicin (ESP) or calicheamicin (CAL), and dynemicin (DYN) has yet to cleave ...
J M, Battigello, M, Cui, S, Roshong, B J, Carter   +3 more
openaire   +2 more sources

Label-Free and Enzyme-Free Colorimetric Detection of Pb2+ Based on RNA Cleavage and Annealing-Accelerated Hybridization Chain Reaction.

Analytical Chemistry, 2019
A label-free and enzyme-free colorimetric sensor for rapid detection of Pb2+ is reported, which is based on the strategy of DNAzyme-mediated RNA cleavage combined with an annealing-accelerated DNA hybridization chain reaction (HCR). As a trigger DNA, the
Zhijun Huang, Junman Chen, Zewei Luo, Xiaqing Wang, Y. Duan   +4 more
semanticscholar   +1 more source

Effect of Ribose Conformation on RNA Cleavage via Internal Transesterification.

Journal of the American Chemical Society, 2018
RNA cleavage via internal transesterification is a fundamental reaction involved in RNA processing and metabolism, and the regulation thereof. Herein, the influence of ribose conformation on this reaction was investigated with conformationally ...
Fengmin Guo, Zekun Yue, Marko Trajkovski, Xiaoping Zhou, Dong Cao, Qiang Li, Baifan Wang, Xin Wen, J. Plavec, Q. Peng, Z. Xi, Chuanzheng Zhou   +11 more
semanticscholar   +1 more source

Cleavage of RNA oligonucleotides by aminoglycosides

Org. Biomol. Chem., 2009
A number of aminoglycoside antibiotics, and in particular neomycin B, are demonstrated to promote strand cleavage of RNA oligonucleotides (minimised HIV-1 TAR element and prokaryotic ribosomal A-site), by binding and causing sufficient distortion to the RNA backbone to render it more susceptible to intramolecular transesterification.
Matthew J, Belousoff, Bim, Graham, Leone, Spiccia, Yitzhak, Tor   +3 more
openaire   +2 more sources

Chemical Diversity in RNA Cleavage

Science, 1999
It was quite a shock when it was first discovered that RNA can perform catalysis, sometimes every bit as efficiently as an enzyme. In his Perspective, [Westhof][1] now describes new evidence ([ Perrotta et al. ][2]) that so-called ribozymes can perform base-catalysis without the assistance of a metal ion. In an early world containing only RNA molecules,
openaire   +2 more sources

[Hybridase cleavage of RNA. I. Oligonucleotide probes for regiospecific RNA cleavage].

Bioorganicheskaia khimiia, 1990
New oligonucleotide probes for regiospecific cleavage of RNA molecules by hybridase (RNase H) are suggested. RNase H from E. coli is shown to site-specifically split eight phosphodiester bonds in RNA in the heteroduplex, formed by 5S rRNA and d(ACCACCGCGCT).
V G, Metelev, N F, Krynetskaia, A A, Purmal', Z A, Shabarova   +3 more
openaire   +1 more source

RNA-mediated programmable DNA cleavage

Nature Biotechnology, 2012
Genome engineering has a new tool—endonucleases involved in bacterial adaptive immunity that can be reprogrammed with customizable small, noncoding RNAs.
openaire   +1 more source

Oligonucleotide-Peptide Conjjugates for RNA Cleavage

Nucleosides and Nucleotides, 1997
Abstract Directed cleavage of RNA phosphodiester bonds by peptidyloligodeoxyribonucleotide containing the peptide residues with the alternated hydrophobic and basic amino acids was demonstrated.
D. Pyshnyi, M. Repkova, S. Lokhov, E. Ivanova, A. Venyaminova, V. Zarytova   +5 more
openaire   +1 more source

Cleavage of RNA by Imidazole

2004
Development of RNA cleaving agents, artificial RNases, has attracted considerable attention in the last years, because they can find important applications in biotechnology, for manipulating RNA, and in drug design. A direct approach to design of artificial RNases consists in imitation of the active centers of natural enzymes by simple organic ...
V. V. Vlassov, A. V. Vlassov
openaire   +1 more source

The self-cleavage of lariat-RNA

Tetrahedron Letters, 1993
Abstract Lariat-RNAs 3 and 4 undergo site-specific self-cleavage reaction at the G 3 → C 6 /U 7 phosphodiester bond by the nucleophilic attack of 2′-OH of G 3 sugar moiety to its 3′-phosphate to give 5′-hydroxyl terminal at C 6 or U 7 and 2′,3′-cyclic phosphodiester of G 3 whereas lariat-tetramer 1 , pentamer 2 , the cyclic-A(2′→5′)G ...
Peter Agback, Corine Glemarec, Lee Yin, Anders Sandström, Janez Plavec, Christian Sund, Shun-ichi Yamakage, Garimella Viswanadham, Bertrand Rousse, Nitin Puri, Jyoti Chattopadhyaya   +10 more
openaire   +1 more source