Long Non-Coding RNAs: New Players in Hematopoiesis and Leukemia [PDF]
, 2015 Long non-coding RNAs (lncRNAs) are important regulators of gene expression that influence almost every step in the life cycle of genes, from transcription to mRNA splicing, RNA decay, and translation.
Ballarino, Monica +2 more
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UPFront and center in RNA decay: UPF1 in nonsense-mediated mRNA decay and beyond
RNA: A publication of the RNA Society, 2019 Nonsense-mediated mRNA decay (NMD), which is arguably the best-characterized translation-dependent regulatory pathway in mammals, selectively degrades mRNAs as a means of post-transcriptional gene control.
Yoon Ki Kim, L. Maquat
semanticscholar +1 more source
The human ZC3H3 and RBM26/27 proteins are critical for PAXT-mediated nuclear RNA decay
Nucleic Acids Research, 2020 Recruitment of the human ribonucleolytic RNA exosome to nuclear polyadenylated (pA+) RNA is facilitated by the Poly(A) Tail eXosome Targeting (PAXT) connection. Besides its core dimer, formed by the exosome co-factor MTR4 and the ZFC3H1 protein, the PAXT
Toomas Silla +11 more
semanticscholar +1 more source
Complementarity of end regions increases the lifetime of small RNAs in mammalian cells. [PDF]
PLoS ONE, 2012 Two RNAs (4.5SH and 4.5SI) with unknown functions share a number of features: short length (about 100 nt), transcription by RNA polymerase III, predominately nuclear localization, the presence in various tissues, and relatively narrow taxonomic ...
Anastasia P Koval +3 more
doaj +1 more source
Low-energy neutrino physics and neutrino mass [PDF]
, 1984 Among the principal concerns in neutrino physics today are the questions of whether neutrinos are massive and, if so, whether the neutrinos emitted in a weak decay are pure or mixed quantum states. The concept of mixed neutrinos has been with us for more
Boehm, F., Vogel, P.
core +1 more source
MARVELD1 Inhibits Nonsense-Mediated RNA Decay by Repressing Serine Phosphorylation of UPF1. [PDF]
PLoS ONE, 2013 We have observed low expression levels of MARVELD1, a novel tumor repressor, in multiple tumors; however, its function in normal cells has not been explored.
Jianran Hu, Yu Li, Ping Li
doaj +1 more source
Interaction Between LncRNA and UPF1 in Tumors
Frontiers in Genetics, 2021 Long non-coding RNAs (LncRNAs) can bind to other proteins or RNAs to regulate gene expression, and its role in tumors has been extensively studied. A common RNA binding protein, UPF1, is also a key factor in a variety of RNA decay pathways.
Junjian He +3 more
doaj +1 more source
Identification and characterization of novel factors that act in the nonsense-mediated mRNA decay pathway in nematodes, flies and mammals [PDF]
, 2014 Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that degrades mRNAs harboring premature termination codons (PTCs). We have conducted a genome-wide RNAi screen in Caenorhabditis elegans that resulted in the identification of five novel NMD ...
Ailion M +8 more
core +2 more sources
Impact of nonsense-mediated mRNA decay on the global expression profile of budding yeast. [PDF]
PLoS Genetics, 2006 Nonsense-mediated mRNA decay (NMD) is a eukaryotic mechanism of RNA surveillance that selectively eliminates aberrant transcripts coding for potentially deleterious proteins. NMD also functions in the normal repertoire of gene expression.
Qiaoning Guan +7 more
doaj +1 more source
Consequences for Pancreatic β-Cell Identity and Function of Unregulated Transcript Processing
Frontiers in Endocrinology, 2021 Mounting evidence suggests a role for alternative splicing (AS) of transcripts in the normal physiology and pathophysiology of the pancreatic β-cell. In the apparent absence of RNA repair systems, RNA decay pathways are likely to play an important role ...
Seyed M. Ghiasi, Guy A. Rutter
doaj +1 more source