Results 51 to 60 of about 208,041 (335)
Cell Reports, 2018 Summary: Nuclear RNA metabolism is influenced by protein complexes connecting to both RNA-productive and -destructive pathways. The ZC3H18 protein binds the cap-binding complex (CBC), universally present on capped RNAs, while also associating with the ...
Kinga Winczura +7 more
doaj +1 more source
RNA Decay Factor UPF1 Promotes Protein Decay: A Hidden Talent [PDF]
BioEssays, 2017 The RNA‐binding protein, UPF1, is best known for its central role in the nonsense‐mediated RNA decay (NMD) pathway. Feng et al. now report a new function for UPF1—it is an E3 ubiquitin ligase that specifically promotes the decay of a key pro‐muscle transcription factor: MYOD.
Plank, Terra‐Dawn M +1 more
openaire +4 more sources
Post-transcriptional regulation of satellite cell quiescence by TTP-mediated mRNA decay. [PDF]
, 2015 Skeletal muscle satellite cells in their niche are quiescent and upon muscle injury, exit quiescence, proliferate to repair muscle tissue, and self-renew to replenish the satellite cell population.
Blackshear, Perry J +7 more
core +2 more sources
Kaposi's sarcoma-associated herpesvirus ORF57 protein binds and protects a nuclear noncoding RNA from cellular RNA decay pathways. [PDF]
PLoS Pathogens, 2010 The control of RNA stability is a key determinant in cellular gene expression. The stability of any transcript is modulated through the activity of cis- or trans-acting regulatory factors as well as cellular quality control systems that ensure the ...
Brooke B Sahin +2 more
doaj +1 more source
Identification and functional analysis of novel phosphorylation sites in the RNA surveillance protein Upf1. [PDF]
, 2013 One third of inherited genetic diseases are caused by mRNAs harboring premature termination codons as a result of nonsense mutations. These aberrant mRNAs are degraded by the Nonsense-Mediated mRNA Decay (NMD) pathway.
Bracho, Dina P +11 more
core +1 more source
Twenty years of RNA and mRNA decay [PDF]
RNA, 2015 Happy 20th anniversary RNA journal! It is hard to believe it has already been two decades since the inception of the journal. I still remember the excitement within the RNA community upon hearing that the RNA Society would have its own journal. Over the years, RNA has proven itself as a major venue for disseminating quality research on RNA biology and ...
openaire +3 more sources
Analysis of RNA decay factor mediated RNA stability contributions on RNA abundance [PDF]
BMC Genomics, 2015 Histone epigenome data determined by chromatin immunoprecipitation sequencing (ChIP-seq) is used in identifying transcript regions and estimating expression levels. However, this estimation does not always correlate with eventual RNA expression levels measured by RNA sequencing (RNA-seq).
Takuma Irie +11 more
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Identification of novel post-transcriptional features in olfactory receptor family mRNAs. [PDF]
, 2015 Olfactory receptor (Olfr) genes comprise the largest gene family in mice. Despite their importance in olfaction, how most Olfr mRNAs are regulated remains unexplored.
Espinoza, Josh L +3 more
core +1 more source
Identification and characterization of novel factors that act in the nonsense-mediated mRNA decay pathway in nematodes, flies and mammals [PDF]
, 2014 Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that degrades mRNAs harboring premature termination codons (PTCs). We have conducted a genome-wide RNAi screen in Caenorhabditis elegans that resulted in the identification of five novel NMD ...
Ailion M +8 more
core +1 more source
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2013 The post-transcriptional addition of non-templated nucleotides to the 3' ends of RNA molecules can have a profound impact on their stability and biological function. Evidence accumulated over the past few decades has identified roles for polyadenylation in RNA stabilisation, degradation and, in the case of eukaryotic mRNAs, translational competence. By
Scott, D, Norbury, C
openaire +3 more sources