Results 71 to 80 of about 218,010 (194)
Genome-wide profiling of uncapped mRNA [PDF]
, 2012 Gene transcripts are under extensive posttranscriptional regulation, including the regulation of their stability. A major route for mRNA degradation produces uncapped mRNAs, which can be generated by decapping enzymes, endonucleases, and small RNAs ...
BD Gregory +9 more
core +2 more sources
Short RNA half-lives in the slow-growing marine cyanobacterium Prochlorococcus [PDF]
, 2010 Background: RNA turnover plays an important role in the gene regulation of microorganisms and influences their speed of acclimation to environmental changes.
Claudia Steglich +5 more
core +5 more sources
Nature CommunicationsMetazoan histone mRNAs are a unique class of mRNAs that lack the poly(A) tail present in all other eukaryotic transcripts. Instead, they end in a conserved stem-loop (SL) structure, necessitating a decay mechanism that is distinct from deadenylation ...
Alexandrina Machado de Amorim +15 more
doaj +1 more source
, 2012 Asymptotic normalization coefficients (ANCs) are fundamental nuclear constants playing important role in nuclear reactions, nuclear structure and nuclear astrophysics.
A. I. Baz' +18 more
core +1 more source
Identification and functional analysis of novel phosphorylation sites in the RNA surveillance protein Upf1. [PDF]
, 2013 One third of inherited genetic diseases are caused by mRNAs harboring premature termination codons as a result of nonsense mutations. These aberrant mRNAs are degraded by the Nonsense-Mediated mRNA Decay (NMD) pathway.
Bracho, Dina P +11 more
core +1 more source
Use of Cellular Decapping Activators by Positive-Strand RNA Viruses
Viruses, 2016 Positive-strand RNA viruses have evolved multiple strategies to not only circumvent the hostile decay machinery but to trick it into being a priceless collaborator supporting viral RNA translation and replication.
Jennifer Jungfleisch +2 more
doaj +1 more source
Nature Communications, 2022 Nucleocytoplasmic shuttling of several yeast mRNA decay factors regulates transcription and initiates a novel mRNA decay pathway; shuttling is controlled by the decaying RNA and is critical for coping with environmental changes.
Shiladitya Chattopadhyay +15 more
doaj +1 more source
Identification and characterization of novel factors that act in the nonsense-mediated mRNA decay pathway in nematodes, flies and mammals [PDF]
, 2014 Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that degrades mRNAs harboring premature termination codons (PTCs). We have conducted a genome-wide RNAi screen in Caenorhabditis elegans that resulted in the identification of five novel NMD ...
Ailion M +8 more
core +2 more sources
Widespread Co-translational RNA Decay Reveals Ribosome Dynamics [PDF]
Cell, 2015 It is generally assumed that mRNAs undergoing translation are protected from decay. Here, we show that mRNAs are, in fact, co-translationally degraded. This is a widespread and conserved process affecting most genes, where 5'-3' transcript degradation follows the last translating ribosome, producing an in vivo ribosomal footprint.
Pelechano V, Wei W, Steinmetz LM
openaire +3 more sources
The role of RNA helicases in aging and lifespan regulation
Translational Medicine of Aging, 2017 RNA helicases are members of a large family of enzymes that function in unwinding RNA duplexes and modulating interactions between RNAs and proteins. RNA helicases participate in numerous cellular processes, including transcription, translation, mRNA ...
Sangsoon Park +3 more
doaj +1 more source