The translational repressors Nanos and Pumilio have divergent effects on presynaptic terminal growth and postsynaptic glutamate receptor subunit composition [PDF]
, 2009 Pumilio (Pum) is a translational repressor that binds selectively to target mRNAs and recruits Nanos (Nos) as a corepressor. In the larval neuromuscular system, Pum represses expression of the translation factor eIF-4E and the glutamate receptor subunit ...
Andrews, Shane +4 more
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Stress and the nonsense-mediated RNA decay pathway [PDF]
Cellular and Molecular Life Sciences, 2017 Cells respond to internal and external cellular stressors by activating stress-response pathways that re-establish homeostasis. If homeostasis is not achieved in a timely manner, stress pathways trigger programmed cell death (apoptosis) to preserve organism integrity.
Alexandra E, Goetz, Miles, Wilkinson
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Nature Communications, 2020 How maternal RNA clearance is regulated in human preimplantation embryos is unclear. Here, the authors show there is a potential correlation between maternal mRNA decay defects and early developmental arrest from in vitro fertilized human embryos ...
Qian-Qian Sha +8 more
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RNA decay: a novel therapeutic target in bacteria [PDF]
WIREs RNA, 2012 AbstractThe need for novel antibiotics is greater now than perhaps any time since the pre‐antibiotic era. Indeed, the recent collapse of most pharmaceutical antibacterial groups, combined with the emergence of hypervirulent and pan‐antibiotic‐resistant bacteria have, in effect, created a ‘perfect storm’ that has severely compromised infection treatment
Tess M, Eidem +2 more
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DNA hybridization catalysts and catalyst circuits [PDF]
, 2005 Practically all of life's molecular processes, from chemical synthesis to replication, involve enzymes that carry out their functions through the catalysis of metastable fuels into waste products.
A.J. Turberfield +18 more
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Investigating the mechanism behind the feedback regulation of the Exon Junction Complex component MAGOH [PDF]
, 2020 RNA binding proteins are critical for regulation of RNA function, and therefore maintaining appropriate levels of these proteins is important for cellular regulation.
Nega, Abigail
core
Twenty years of RNA and mRNA decay [PDF]
RNA, 2015 Happy 20th anniversary RNA journal! It is hard to believe it has already been two decades since the inception of the journal. I still remember the excitement within the RNA community upon hearing that the RNA Society would have its own journal. Over the years, RNA has proven itself as a major venue for disseminating quality research on RNA biology and ...
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Dual RNA Processing Roles of Pat1b via Cytoplasmic Lsm1-7 and Nuclear Lsm2-8 Complexes
Cell Reports, 2017 Summary: Pat1 RNA-binding proteins, enriched in processing bodies (P bodies), are key players in cytoplasmic 5′ to 3′ mRNA decay, activating decapping of mRNA in complex with the Lsm1-7 heptamer.
Caroline Vindry +10 more
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The 5'-3' exoribonuclease pacman is required for epithelial sheet sealing in Drosophila and genetically interacts with the phosphatase puckered [PDF]
, 2008 Background information. Ribonucleases have been well studied in yeast and bacteria, but their biological significance to developmental processes in multicellular organisms is not well understood.
Browne, Cathy +7 more
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Attacked from All Sides: RNA Decay in Antiviral Defense
Viruses, 2017 The innate immune system has evolved a number of sensors that recognize viral RNA (vRNA) to restrict infection, yet the full spectrum of host-encoded RNA binding proteins that target these foreign RNAs is still unknown.
Jerome M. Molleston, Sara Cherry
doaj +1 more source