Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis. [PDF]
, 2016 Colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer-related mortality. Observed during CRC tumorigenesis is loss of post-transcriptional regulation of tumor-promoting genes such as COX-2, TNFα and VEGF. Overexpression of
Aguado, Andrea +12 more
core +2 more sources
Full UPF3B function is critical for neuronal differentiation of neural stem cells [PDF]
, 2015 Acknowledgments We thank Fred H Gage (Salk Institute, La Jolla, CA, USA) for HCN-A94 cells and Niels Gehring (University of Cologne, Germany) for constructs.
Alrahbeni, Tahani +5 more
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Interaction of yeast eIF4G with spliceosome components Implications in pre-mRNA processing events [PDF]
, 2009 International audienceAs evidenced from mammalian cells the eukaryotic translation initiation factor eIF4G has a putative role in nuclear RNA metabolism. Here we investigate whether this role is conserved in the yeast Saccharomyces cerevisiae.
Barrass, J. David +6 more
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Multi-omic Analyses of Extensively Decayed Pinus contorta Reveal Expression of a Diverse Array of Lignocellulose-Degrading Enzymes. [PDF]
, 2018 Fungi play a key role cycling nutrients in forest ecosystems, but the mechanisms remain uncertain. To clarify the enzymatic processes involved in wood decomposition, the metatranscriptomics and metaproteomics of extensively decayed lodgepole pine were ...
Barry, Kerrie +13 more
core
Multiple decay events target HAC1 mRNA during splicing to regulate the unfolded protein response
eLife, 2019 In the unfolded protein response (UPR), stress in the endoplasmic reticulum (ER) activates a large transcriptional program to increase ER folding capacity.
Patrick D Cherry +2 more
doaj +1 more source
tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay. [PDF]
, 2019 Yeast tRNA ligase (Trl1) is an essential trifunctional enzyme that catalyzes exon-exon ligation during tRNA biogenesis and the non-conventional splicing of HAC1 mRNA during the unfolded protein response (UPR).
Peschek, Jirka, Walter, Peter
core
RNA Decay by the Eukaryotic Exosome [PDF]
Biophysical Journal, 2009 The eukaryotic RNA exosome is a multi-subunit protein complex that regulates RNA processing and decay in processes that maintain the quality and abundance of cellular RNA. The subunit composition and activities of eukaryotic exosomes were determined by reconstituting exosomes from yeast and human.
openaire +1 more source
Nonsense-Mediated RNA Decay Influences Human Embryonic Stem Cell Fate
Stem Cell Reports, 2016 Summary: Nonsense-mediated RNA decay (NMD) is a highly conserved pathway that selectively degrades specific subsets of RNA transcripts. Here, we provide evidence that NMD regulates early human developmental cell fate. We found that NMD factors tend to be
Chih-Hong Lou +10 more
doaj +1 more source
Enzymes of physiological amyloidogenesis control pathological amyloid toxicity
Life Science AllianceThis study finds that modulating RNA tailing and decay enzymes can regulate proteotoxicity in Alzheimer’s and Parkinson’s disease models. Physiological amyloidogenesis drives the formation of functional amyloids involved in various biochemical pathways ...
Michael Bokros +5 more
doaj +1 more source
Composition and conservation of the mRNA-degrading machinery in bacteria
Journal of Biomedical Science, 2011 RNA synthesis and decay counteract each other and therefore inversely regulate gene expression in pro- and eukaryotic cells by controlling the steady-state level of individual transcripts.
Kaberdin Vladimir R +2 more
doaj +1 more source