Results 81 to 90 of about 208,041 (335)
On the edge of degradation: Autophagy regulation by RNA decay [PDF]
WIREs RNA, 2018 Cells must dynamically adapt to altered environmental conditions, particularly during times of stress, to ensure their ability to function effectively and survive. The macroautophagy/autophagy pathway is highly conserved across eukaryotic cells and promotes cell survival during stressful conditions.
Delorme‐axford, Elizabeth +1 more
openaire +4 more sources
FEBS Open Bio, EarlyView.TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo +11 more
wiley +1 more source
RNA decay: a novel therapeutic target in bacteria [PDF]
WIREs RNA, 2012 AbstractThe need for novel antibiotics is greater now than perhaps any time since the pre‐antibiotic era. Indeed, the recent collapse of most pharmaceutical antibacterial groups, combined with the emergence of hypervirulent and pan‐antibiotic‐resistant bacteria have, in effect, created a ‘perfect storm’ that has severely compromised infection treatment
Christelle M. Roux +2 more
openaire +2 more sources
The translational repressors Nanos and Pumilio have divergent effects on presynaptic terminal growth and postsynaptic glutamate receptor subunit composition [PDF]
, 2009 Pumilio (Pum) is a translational repressor that binds selectively to target mRNAs and recruits Nanos (Nos) as a corepressor. In the larval neuromuscular system, Pum represses expression of the translation factor eIF-4E and the glutamate receptor subunit ...
Andrews, Shane +4 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT C‐truncating variants in the charged multivesicular body protein 2B (CHMP2B) gene are a rare cause of frontotemporal lobar degeneration (FTLD), previously identified only in Denmark, Belgium, and China. We report a novel CHMP2B splice‐site variant (c.35‐1G>A) associated with familial FTLD in Spain. The cases were two monozygotic male twins who
Sara Rubio‐Guerra +17 more
wiley +1 more source
Use of Cellular Decapping Activators by Positive-Strand RNA Viruses
Viruses, 2016 Positive-strand RNA viruses have evolved multiple strategies to not only circumvent the hostile decay machinery but to trick it into being a priceless collaborator supporting viral RNA translation and replication.
Jennifer Jungfleisch +2 more
doaj +1 more source
Nature Communications, 2022 Nucleocytoplasmic shuttling of several yeast mRNA decay factors regulates transcription and initiates a novel mRNA decay pathway; shuttling is controlled by the decaying RNA and is critical for coping with environmental changes.
Shiladitya Chattopadhyay +15 more
doaj +1 more source
, 2012 Asymptotic normalization coefficients (ANCs) are fundamental nuclear constants playing important role in nuclear reactions, nuclear structure and nuclear astrophysics.
A. I. Baz' +18 more
core +1 more source
Advanced Engineering Materials, EarlyView.Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley +1 more source
The role of RNA helicases in aging and lifespan regulation
Translational Medicine of Aging, 2017 RNA helicases are members of a large family of enzymes that function in unwinding RNA duplexes and modulating interactions between RNAs and proteins. RNA helicases participate in numerous cellular processes, including transcription, translation, mRNA ...
Sangsoon Park +3 more
doaj +1 more source