Results 161 to 170 of about 5,666,730 (325)
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
RNA-Seq samples for glucose utilization and PNP degradation.
, 2016 (A) Glucose utilization in each RNA-Seq sample. The concentration of residual glucose was measured with the DNS method. (B) PNP degradation in samples E4-GP and R-GP. (C) pH variation in P. putida DLL-E4 and DLL-ΔpnpR grown in minimal medium containing 0.
Biying Zhang (3168798) +9 more
core +1 more source
ZnO Nanoparticles Protect RNA from Degradation Better than DNA
Nanomaterials, 2017 Gene therapy and RNA delivery require a nanoparticle (NP) to stabilize these nucleic acids when administered in vivo. The presence of degradative hydrolytic enzymes within these environments limits the nucleic acids’ pharmacologic activity.
Jayden McCall +6 more
doaj +1 more source
Profiling of RNA Degradation for Estimation of Post Morterm Interval
PLoS ONE, 2013 An estimation of the post mortem interval (PMI) is frequently touted as the Holy Grail of forensic pathology. During the first hours after death, PMI estimation is dependent on the rate of physical observable modifications including algor, rigor and ...
Fernanda Sampaio-Silva +4 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Molecular and developmental analysis of non-coding RNA metabolism in" C. elegans" : the exoribonuclease XRN2 and the RNA- binding proteins SART-3 and USIP-1 [PDF]
, 2014 About three quarters of a eukaryotic genome are transcribed into RNA. However, only
Rüegger, Stefan
core +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
RNA polymerase promotes splicing, prevents degradation. [PDF]
PLoS Biology, 2006 Richard Robinson
doaj +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Nature CommunicationsMetazoan histone mRNAs are a unique class of mRNAs that lack the poly(A) tail present in all other eukaryotic transcripts. Instead, they end in a conserved stem-loop (SL) structure, necessitating a decay mechanism that is distinct from deadenylation ...
Alexandrina Machado de Amorim +15 more
doaj +1 more source