Results 211 to 220 of about 806,296 (336)

Exploring Echinacea angustifolia for anti-viral compounds against Zika virus RNA-dependent RNA polymerase: a computational study. [PDF]

Sci Rep
El-Daly MM, Bajrai LH, Alandijany TA, Alsaady IM, Gattan HS, Alhamdan MM, Dwivedi VD, Azhar EI.   +7 more
europepmc   +1 more source

Muscle‐Derived Small Extracellular Vesicles Mediate Exercise‐Induced Cognitive Protection in Chronic Cerebral Hypoperfusion

Advanced Science, EarlyView.
sEVs have a critical role in orchestrating interorgan crosstalk and mediating exercise‐induced therapeutic effects. Lin et al. demonstrates that sEVs miR‐17/20a‐5p mediates the muscle‐brain crosstalk and emphasizes the central role of mTOR signaling in executing molecular programs that can protect brain health in response to exercise. Abstract Physical
Huawei Lin, Lianhua Yin, Weilin Liu, Rui Li, Tao Jiang, Minguang Yang, Yajun Cao, Sinuo Wang, Yan Yu, Cong Chen, Xiaoqin Guo, Wenju Wang, Huanhuan Liu, Yaling Dai, Jiamin Yan, Yanting Lin, Yanyi Ding, Chendong Ruan, Lei Yang, Tiecheng Wu, Jing Tao, Lidan Chen   +21 more
wiley   +1 more source

Contribution of critical amino acid residues in the RNA-dependent RNA polymerase to the replication fidelity and viral ribavirin sensitivity of porcine reproductive and respiratory syndrome virus. [PDF]

Vet Res
Zhang X, Yang Z, Zhang Z, Wang Z, Zhao Y, Yang T, Gong J, Feng K, He J, Zheng Q, Hou J, Li P.   +11 more
europepmc   +1 more source

Stereochemistry of polymerization by DNA-dependent RNA-polymerase from Escherichia coli: an investigation with a diastereomeric ATP-analogue.

, 1976
F. Eckstein, Victor W. Armstrong, Hans Sternbach   +2 more
openalex   +1 more source

Daunorubicin Inhibition of DNA‐Dependent RNA Polymerases from Ehrlich Ascites Tumor Cells [PDF]

, 1976
Véronique Barthelemy-Clavey, Catherine MOLINIER, Geneviève Aubel‐Sadron, R Maral   +3 more
openalex   +1 more source

The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges

Advanced Science, EarlyView.
This paper summarizes the potential of biomaterials, stem cells, and gene editing technologies in the regeneration of inner ear hair cells, spiral ganglion neurons, and inner ear organoids. Challenges and potential developments are discussed and explored.
Zhe Li, Ying Zhang, Zhenyu Xiao, Jieyu Qi   +3 more
wiley   +1 more source

Biochemical characterization of naturally occurring mutations in SARS-CoV-2 RNA-dependent RNA polymerase. [PDF]

Protein Sci
Danda M, Klimešová A, Kušková K, Dostálková A, Pagáčová A, Prchal J, Kapisheva M, Ruml T, Rumlová M.   +8 more
europepmc   +1 more source

Investigating the Mechanism of Action of Anti-Dengue Compounds as Potential Binders of Zika Virus RNA-Dependent RNA Polymerase. [PDF]

Viruses, 2023
Alandijany TA, El-Daly MM, Tolah AM, Bajrai LH, Khateb AM, Alsaady IM, Altwaim SA, Dubey A, Dwivedi VD, Azhar EI.   +9 more
europepmc   +1 more source

Delivery of A Chemically Modified Noncoding RNA Domain Improves Dystrophic Myotube Function

Advanced Science, EarlyView.
CYTOR is a pro‐myogenic ncRNA in skeletal muscle. Here, chemical probing of CYTOR, coupled with functional cellular assays identifies exon 2 as an independent myogenic RNA domain. Chemical engineering of CYTOR exon 2 RNA improves pharmacologic properties, including RNA stability and cell‐autonomous immunogenicity.
Zeinabou Niasse‐Sy, Bo Zhao, Ajda Lenardič, Huyen Thuc Tran Luong, Ori Bar‐Nur, Johan Auwerx, Martin Wohlwend   +6 more
wiley   +1 more source

Molecular Evolutionary Analyses of the RNA-Dependent RNA Polymerase (RdRp) Region and VP1 Gene in Sapovirus GI.1 and GI.2. [PDF]

Microorganisms
Mizukoshi F, Kimura R, Shirai T, Hirata-Saito A, Hiraishi E, Murakami K, Doan YH, Tsukagoshi H, Saruki N, Tsugawa T, Kidera K, Suzuki Y, Sakon N, Katayama K, Kageyama T, Ryo A, Kimura H.   +16 more
europepmc   +1 more source