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ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

In silico studies to understand the interactions of flavonoid inhibitor with nsp12-RNA dependent RNA polymerase of SARS-CoV-2 and its homologs. [PDF]

Biochem Biophys Rep
Kizhakkiniyakath SA, Choudhury T, Rajan MV, Rathee S, Meena B, Hariprasad G.   +5 more
europepmc   +1 more source

Exploring Echinacea angustifolia for anti-viral compounds against Zika virus RNA-dependent RNA polymerase: a computational study. [PDF]

Sci Rep
El-Daly MM, Bajrai LH, Alandijany TA, Alsaady IM, Gattan HS, Alhamdan MM, Dwivedi VD, Azhar EI.   +7 more
europepmc   +1 more source

Recovery of RNA-dependent RNA polymerase 6 gene-knockout phenotypes in Nicotiana benthamiana via in vivo generation of inverted repeat construct of the trans-acting short interference RNA3 sequence. [PDF]

Plant J
Matsuo K.
europepmc   +1 more source

Repurposing FDA-approved drugs and natural compounds to inhibit the RNA-dependent RNA polymerase domain of dengue virus 2 or dengue virus 3. [PDF]

Sci Rep
Ahmadi K, Jahantigh HR, Ahmadi N, Shahbazi B.   +3 more
europepmc   +1 more source

RNA-dependent RNA polymerase of predominant human norovirus forms liquid-liquid phase condensates as viral replication factories. [PDF]

Sci Adv
Kaundal S, Anish R, Ayyar BV, Shanker S, Kaur G, Crawford SE, Pollet J, Stossi F, Estes MK, Prasad BVV.   +9 more
europepmc   +1 more source

Molecular Evolutionary Analyses of the RNA-Dependent RNA Polymerase (RdRp) Region and VP1 Gene in Sapovirus GI.1 and GI.2. [PDF]

Microorganisms
Mizukoshi F, Kimura R, Shirai T, Hirata-Saito A, Hiraishi E, Murakami K, Doan YH, Tsukagoshi H, Saruki N, Tsugawa T, Kidera K, Suzuki Y, Sakon N, Katayama K, Kageyama T, Ryo A, Kimura H.   +16 more
europepmc   +1 more source

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Modulation of Noncoding RNAs (ncRNAs) and Their Potential Role as Therapeutics

Medical Epigenetics, 2021
Luciano Pirola, Aneta Balcerczyk, Oskar Ciesielski   +2 more
exaly