Results 121 to 130 of about 2,153,086 (396)
RNA editing regulates insect gamma-aminobutyric acid receptor function and insecticide sensitivity [PDF]
, 2008 A-to-I pre-mRNA editing by adenosine deaminase enzymes has been reported to enhance protein diversity in the nervous system. In Drosophila, the resistance to dieldrin (RDL) gamma-aminobutyric acid (GABA) receptor subunit displays an editing site (R122 ...
A. Hamon +3 more
core +2 more sources
Molecular Oncology, EarlyView.Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma +9 more
wiley +1 more source
A-to-I RNA editing does not change with age in the healthy male rat brain [PDF]
, 2013 RNA editing is a post-transcriptional process, which results in base substitution modifications to RNA. It is an important process in generating protein diversity through amino acid substitution and the modulation of splicing events.
Andrew P. Holmes +3 more
core +1 more source
Molecular Oncology, EarlyView.This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh +8 more
wiley +1 more source
Proteins that contain a functional Z-DNA-binding domain localize to cytoplasmic stress granules [PDF]
, 2013 Long double-stranded RNA may undergo hyper-editing by adenosine deaminases that act on RNA (ADARs), where up to 50% of adenosine residues may be converted to inosine.
Ng, Siew Kit +3 more
core +1 more source
GUN1 interacts with MORF2 to regulate plastid RNA editing during retrograde signaling
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Retrograde signaling and posttranscriptional RNA editing are important regulatory processes for chloroplast development and function in flowering plants. GUN1 is a central integrator of chloroplast retrograde signaling pathways.
Xiaobo Zhao, Jianyan Huang, J. Chory
semanticscholar +1 more source
BMC Biology, 2020 Adenosine-to-inosine (A-to-I) RNA editing is a process that contributes to the diversification of proteins that has been shown to be essential for neurotransmission and other neuronal functions.
Elin Lundin +7 more
semanticscholar +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Molecular Therapy: Nucleic AcidsRNA editing, a common and potentially highly functional form of RNA modification, encompasses two different RNA modifications, namely adenosine to inosine (A-to-I) and cytidine to uridine (C-to-U) editing. As inosines are interpreted as guanosines by the
Korina Karagianni +12 more
doaj +1 more source
dsRNA expression in the mouse elicits RNAi in oocytes and low adenosine deamination in somatic cells [PDF]
, 2017 Double-stranded RNA (dsRNA) can enter different pathways in mammalian cells, including sequence-specific RNA interference (RNAi), sequence-independent interferon (IFN) response and editing by adenosine deaminases.
Filipowicz, Witold +5 more
core