Results 121 to 130 of about 2,133,969 (419)
Evolutionary analysis reveals regulatory and functional landscape of coding and non-coding RNA editing. [PDF]
PLoS Genetics, 2017 Adenosine-to-inosine RNA editing diversifies the transcriptome and promotes functional diversity, particularly in the brain. A plethora of editing sites has been recently identified; however, how they are selected and regulated and which are functionally
Rui Zhang +3 more
doaj +1 more source
Exploration of RNA Editing and Design of Robust Genetic Algorithms [PDF]
arXiv, 2003 This paper presents our computational methodology using Genetic Algorithms (GA) for exploring the nature of RNA editing. These models are constructed using several genetic editing characteristics that are gleaned from the RNA editing system as observed in several organisms.
arxiv
Statistical-physics approaches to RNA molecules, families and networks [PDF]
arXiv, 2022 This contribution focuses on the fascinating RNA molecule, its sequence-dependent folding driven by base-pairing interactions, the interplay between these interactions and natural evolution, and its multiple regulatory roles. The four of us have dug into these topics using the tools and the spirit of the statistical physics of disordered systems, and ...
arxiv
Computer simulations explain mutation-induced effects on the DNA editing by adenine base editors. [PDF]
, 2020 Adenine base editors, which were developed by engineering a transfer RNA adenosine deaminase enzyme (TadA) into a DNA editing enzyme (TadA*), enable precise modification of A:T to G⋮C base pairs. Here, we use molecular dynamics simulations to uncover the
Komor, Alexis C +2 more
core
, 1970 Discoba (Excavata) is an ancient group of eukaryotes with great morphological and ecological diversity. Unlike the other major divisions of Discoba (Jakobida and Euglenozoa), little is known about the mitochondrial DNAs(mtDNAs) of Heterolobosea.
Andersson, Siv G. E. +4 more
core +2 more sources
Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma
Molecular Oncology, EarlyView.This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu +15 more
wiley +1 more source
A hierarchy in clusters of cephalopod mRNA editing sites
Scientific Reports, 2022 RNA editing in the form of substituting adenine with inosine (A-to-I editing) is the most frequent type of RNA editing in many metazoan species. In most species, A-to-I editing sites tend to form clusters and editing at clustered sites depends on editing
Mikhail A. Moldovan +3 more
doaj +1 more source
Comparing RNA structures using a full set of biologically relevant edit operations is intractable [PDF]
arXiv, 2008 Arc-annotated sequences are useful for representing structural information of RNAs and have been extensively used for comparing RNA structures in both terms of sequence and structural similarities. Among the many paradigms referring to arc-annotated sequences and RNA structures comparison (see \cite{IGMA_BliDenDul08} for more details), the most ...
arxiv
Mutations underlying Episodic Ataxia type-1 antagonize Kv1.1 RNA editing [PDF]
, 2017 © The Author(s), 2017. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Scientific Reports 7 (2017): 41095, doi:10.1038/srep41095.Adenosine-to-inosine RNA editing in ...
Ayers, Gregory D. +3 more
core +1 more source
Widespread RNA editing dysregulation in brains from autistic individuals
Nature Neuroscience, 2018 Transcriptomic analyses of postmortem brains have begun to elucidate molecular abnormalities in autism spectrum disorder (ASD). However, a crucial pathway involved in synaptic development, RNA editing, has not yet been studied on a genome-wide scale ...
Stephen S. Tran +14 more
semanticscholar +1 more source