Results 161 to 170 of about 2,133,969 (419)
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
An extra double-stranded RNA binding domain confers high activity to a squid RNA editing enzyme [PDF]
, 2009 RNA editing by adenosine deamination is particularly prevalent in the squid nervous system. We hypothesized that the squid editing enzyme might contain structural differences that help explain this phenomenon. As a first step, a squid adenosine deaminase
O'Connell, Mary A +2 more
core +2 more sources
RNA editing underlies genetic risk of common inflammatory diseases
Nature, 2022 Qin Li +11 more
semanticscholar +1 more source
RNA editing in the forefront of epitranscriptomics and human health
Journal of Translational Medicine, 2019 Post-transcriptional modifications have been recently expanded with the addition of RNA editing, which is predominantly mediated by adenosine and cytidine deaminases acting on DNA and RNA.
Theodoulakis Christofi, A. Zaravinos
semanticscholar +1 more source
Molecular Oncology, EarlyView.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho +11 more
wiley +1 more source
Programmable RNA editing with compact CRISPR–Cas13 systems from uncultivated microbes
Nature Methods, 2021 Chunlong Xu +15 more
semanticscholar +1 more source
Nature Methods, 2013 Targeted gene modification can be guided by programmable RNA in bacteria, zebrafish and mammalian cells.
openaire +2 more sources
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
Gene and RNA Editing: Methods, Enabling Technologies, Applications, and Future Directions [PDF]
arXivGene and RNA editing methods, technologies, and applications are emerging as innovative forms of therapy and medicine, offering more efficient implementation compared to traditional pharmaceutical treatments. Current trends emphasize the urgent need for advanced methods and technologies to detect public health threats, including diseases and viral ...
arxiv
Artificial and Natural Genetic Information Processing [PDF]
, 2017 Conventional methods of genetic engineering and more recent genome editing techniques focus on identifying genetic target sequences for manipulation.
Witzany, Guenther
core