Results 161 to 170 of about 1,495,760 (258)

Site-specific neoepitope induction by RNA editing reprograms tumor immunogenicity. [PDF]

Front Immunol
Liu S, Dong C, Chen L, Yan J, Luo X, Huang H, Qiu Z, Gan X, Yang J, Zhu J, Xiong C, Huang L, Wang L, Yang Z, Meng Z, Yi S, Chen Y, Zuo C, Leng Q, Wang X.   +19 more
europepmc   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

ADAR-mediated RNA editing in CNS disorders: from pathogenic mechanisms to therapeutic opportunities. [PDF]

Cell Mol Biol Lett
Zheng F, Guan R, Yu X, Yang J, Zhao H, Yang F.   +5 more
europepmc   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

The regulatory mechanism and clinical significance of RNA editing in prostate cancer. [PDF]

Curr Urol
Li S, Li A, Huang Y, Wang Y, Fan M, Jiang X, Bing K, Liang J, Wang K, Xu Z, Wang L.   +10 more
europepmc   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Multi-Tissue Genetic Regulation of RNA Editing in Pigs. [PDF]

Adv Sci (Weinh)
Pan X, Gong W, Cai X, Teng J, Cai J, Zeng H, Ayalew W, Shen Q, Zhong Z, Wang Y, Zhang W, Tian Y, Xu D, Gao Y, Yin H, Zhang Y, Hou J, Zhou T, Li J, Fang L, Yuan X, Zhang Z.   +21 more
europepmc   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

A single-cell transcriptome atlas reveals paradoxical monoallelic expression of RNA editing and heterozygous SNPs. [PDF]

Nucleic Acids Res
Duan Y, Liu J, Xu S, Xie Q, Ma L, Song F, Tian L, Cai W, Cao Q, Li H.   +9 more
europepmc   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source