Results 201 to 210 of about 2,110,017 (419)

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

RNA editing in response to COVID-19 vaccines: unveiling dynamic epigenetic regulation of host immunity

Frontiers in Immunology
BackgroundCOVID-19 vaccines are crucial for reducing the threat and burden of the pandemic on global public health, yet the epigenetic, especially RNA editing in response to the vaccines remains unelucidated.ResultsOur current study performed an ...
Yun-Yun Jin, Yun-Yun Jin, Yun-Yun Jin, Ya-Ping Liang, Ya-Ping Liang, Ya-Ping Liang, Jia-Qi Pan, Jia-Qi Pan, Jia-Qi Pan, Wen-Hao Huang, Wen-Hao Huang, Wen-Hao Huang, Yan-Meng Feng, Yan-Meng Feng, Yan-Meng Feng, Wei-Jia Sui, Wei-Jia Sui, Wei-Jia Sui, Han Yu, Han Yu, Han Yu, Xiao-Dan Tang, Xiao-Dan Tang, Xiao-Dan Tang, Lin Zhu, Lin Zhu, Lin Zhu, Jian-Huan Chen, Jian-Huan Chen, Jian-Huan Chen   +29 more
doaj   +1 more source

In vitro RNA editing-like activity in a mitochondrial extract from Leishmania tarentolae. [PDF]

, 1995
Georges C. Frech, Norbert Bakalara, Larry Simpson, Agda M. Simpson   +3 more
openalex   +1 more source

Artificial and Natural Genetic Information Processing [PDF]

, 2017
Conventional methods of genetic engineering and more recent genome editing techniques focus on identifying genetic target sequences for manipulation.
Witzany, Guenther
core  

Positive feedback loop between MAPK and aquaporin 7 regulates autophagy and apoptosis induced by palmitate in RIN‐m5f cells

FEBS Open Bio, EarlyView.
T2DM is characterized by peripheral blood insulin resistance and progressive pancreatic β‐cell dysfunction. Here, we showed that AQP7, the only aquaglyceroporin protein, regulates autophagy and apoptosis in pancreatic β‐cells. We propose the existence of a positive feedback loop between MAPK signaling and AQP7 that regulates autophagy and apoptosis in ...
Maoqi Wang, Jiang Tan, Xueting He, Yuqin Chen, Guoping Qiu, Mei Yang   +5 more
wiley   +1 more source

Erratum: RNA editing of hepatitis delta virus antigenome by dsRNA-adenosine deaminase [PDF]

, 1996
Andrew G. Polson, Brenda Bass, John Casey   +2 more
openalex   +1 more source

Hydrophobicity causes anomalous migration of cystine/glutamate antiporter SLC7A11 in SDS‐PAGE with low acrylamide concentration

FEBS Open Bio, EarlyView.
SLC7A11 frequently migrates faster in SDS‐PAGE. The present study found that the high hydrophobicity of SLC7A11 causes its anomalous migration in SDS‐PAGE with a low concentration of acrylamide gel. Replacing isoleucine with asparagine reduced hydrophobicity and restored its normal migration at 55 kDa, revealing the role of hydrophobicity and gel ...
Nsengiyumva Emmanuel, Qian He, Yixin Kang, Dianbao Zhang, Min Gao, Minglin Wang, Kexin Fan, Jingwen Xiong, Shaobo Wu, Botao Fa, Zhengtao Xiao, Yingfang Niu, Jun Yao, Yilei Zhang   +13 more
wiley   +1 more source

Zinc Finger RNA-Binding Protein Zn72D Regulates ADAR-Mediated RNA Editing in Neurons

Cell Reports, 2020
Summary: Adenosine-to-inosine RNA editing, catalyzed by adenosine deaminase acting on RNA (ADAR) enzymes, alters RNA sequences from those encoded by DNA. These editing events are dynamically regulated, but few trans regulators of ADARs are known in vivo.
Anne L. Sapiro, Emily C. Freund, Lucas Restrepo, Huan-Huan Qiao, Amruta Bhate, Qin Li, Jian-Quan Ni, Timothy J. Mosca, Jin Billy Li   +8 more
doaj  

Comparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer

FEBS Open Bio, EarlyView.
We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang, Lynn Kee, Alexander Gont, Jalna Meens, Fraser G. Ferens, Meredith S. Irwin, Laurie Ailles, Scott A. Yuzwa, Claire M. Robinson, Michael Ohh   +9 more
wiley   +1 more source

Direct Visualization of Uridylate Deletion In Vitro Suggests a Mechanism for Kinetoplastid RNA Editing [PDF]

, 1996
Scott D. Seiwert, Stefan Heidmann, Kenneth Stuart   +2 more
openalex   +1 more source