Results 321 to 330 of about 2,110,017 (419)

GRP78 Nanobody‐Directed Immunotoxin Activates Innate Immunity Through STING Pathway to Synergize Tumor Immunotherapy

Advanced Science, EarlyView.
A GRP78 nanobody‐directed immunotoxin suppresses cancer progression and metastasis by enhancing antitumor immunity via STING pathway activation, offering a pan‐cancer‐targeted approach and immunotherapy combination strategy. Abstract The lack of targetable antigens poses a significant challenge in developing effective cancer‐targeted therapies.
Huifang Wang, Runhua Zhou, Chengchao Xu, Lingyun Dai, Rui Hou, Liuhai Zheng, Chunjin Fu, Guangwei Shi, Jingwei Wang, Yang Li, Jinpeng Cen, Xiaolong Xu, Le Yu, Yilei Li, Jigang Wang, Qingfeng Du, Zhijie Li   +16 more
wiley   +1 more source

Heterologous, splicing-dependent RNA editing in chloroplasts: allotetraploidy provides trans-factors

, 2001
Christian Schmitz‐Linneweber
openalex   +2 more sources

Fine-tuning of the PPR protein directs the RNA editing activity toward C-to-U or U-to-C conversion. [PDF]

Sci Rep
Ichinose M, Teramoto T, Nakamura I, Shimajiri Y, Yagi Y, Gutmann B.   +5 more
europepmc   +1 more source

RNF112 Facilitates Ubiquitin‐Mediated Degradation of c‐Myc, Suppressing Proliferation, Migration and Lipid Synthesis in Bladder Cancer

Advanced Science, EarlyView.
RNF112, an E3 ubiquitin ligase, is markedly reduced in bladder cancer (BLCA). It curbs BLCA cell proliferation, migration, and lipid production primarily by enhancing ubiquitin‐dependent degradation of c‐Myc. This degradation inhibits c‐Myc's role in upregulating ACLY, a crucial enzyme for lipid synthesis, highlighting RNF112's potential as a ...
Kangping Xiong, Siming Chen, Huimin Xu, Sheng Tu, Hong Weng, Yejinpeng Wang, Mingxing Li, Jingtian Yu, Kaiyu Qian, Lingao Ju, Yi Zhang, Yu Xiao, Xinghuan Wang, Gang Wang   +13 more
wiley   +1 more source

Non-templated addition of nucleotides to the 3′ end of nascent RNA during RNA editing in Physarum

, 2001
Yu‐Wei Cheng, Linda M. Visomirski-Robic, Jonatha M. Gott   +2 more
openalex   +2 more sources

Global A-to-I RNA editing during myogenic differentiation of goat MuSCs. [PDF]

Front Vet Sci
Xu X, Zhang M, Zhan S, Chen Y, Wei C, Cao J, Guo J, Dai D, Wang L, Zhong T, Zhang H, Li L.   +11 more
europepmc   +1 more source

Genome‐Wide Silencer Screening Reveals Key Silencer Modulating Reprogramming Efficiency in Mouse Induced Pluripotent Stem Cells

Advanced Science, EarlyView.
This study utilized Ss‐STARR‐seq to construct a genome‐wide silencer map of mouse cells and elucidated the fundamental characteristics of these silencers. These silencers exist in a cell‐specific manner and exhibit unique epigenetic modifications. Through functional experiments, we also discovered that these silencers can regulate gene expression and ...
Xiusheng Zhu, Lei Huang, Guoli Li, Biao Deng, Xiaoxiao Wang, Hu Yang, Yuanyuan Zhang, Qiuhan Wen, Chao Wang, Jingshu Zhang, Yunxiang Zhao, Kui Li, Yuwen Liu   +12 more
wiley   +1 more source

RNA editing-based biomarker blood test for the diagnosis of bipolar disorder: protocol of the EDIT-B study. [PDF]

Ann Gen Psychiatry
Miranda-Mendizabal A, Vetter D, Zambrano J, Zarp J, Chavarría V, Giménez-Palomo A, Gonzalez-Campos M, Valenti M, Walczer Baldinazzo L, Siddi S, Ferrari M, Weissmann D, Henry C, Haro JM, Vedel Kessing L, Vieta E.   +15 more
europepmc   +1 more source

GDC: Integration of Multi‐Omic and Phenotypic Resources to Unravel the Genetic Pathogenesis of Hearing Loss

Advanced Science, EarlyView.
Overview of the Genetic Deafness Commons (GDC), integrating data from the Chinese Deafness Genetics Consortium (CDGC) and 51 public databases. The GDC provides tools for variant search, functional predictions, and gene‐disease visualization, offering insights into 201 hearing loss genes and facilitating novel gene discovery and clinical applications ...
Hui Cheng, Xuegang Wang, Mingjun Zhong, Jia Geng, Wenjian Li, Kanglu Pei, Jing Wang, Lanchen Wang, Yu Lu, Jing Cheng, Fengxiao Bu, Huijun Yuan   +11 more
wiley   +1 more source

RNA editing is a molecular clock in unmodified human cells

Ghareeb AE, Bayne J, Wagen AZ, Abdelhafid AM, Miller D, Cubitt L, Meran L, Hill C, Cribbs AP, Ryten M, Gandhi S, Gaffney E, Coles M, Young G, Rodriques SG.   +14 more
europepmc   +1 more source