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A-to-I RNA editing — immune protector and transcriptome diversifier
Nature Reviews Genetics, 2018Eli Eisenberg, Erez Y Levanon
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Annual Review of Neuroscience, 1996
RNA editing is a term describing a variety of novel mechanisms for the modification of nucleotide sequences of RNA transcripts in different organisms. These editing events include (a) the U-insertion and -deletion type of editing found in the mitochondrion of kinetoplastid protozoa, (b) the C-insertion editing found in the mitochondrion of Physarum ...
L, Simpson, R B, Emeson
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RNA editing is a term describing a variety of novel mechanisms for the modification of nucleotide sequences of RNA transcripts in different organisms. These editing events include (a) the U-insertion and -deletion type of editing found in the mitochondrion of kinetoplastid protozoa, (b) the C-insertion editing found in the mitochondrion of Physarum ...
L, Simpson, R B, Emeson
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RNA Editing in Interferonopathies
2020The type I interferonopathies comprise a heterogenous group of monogenic diseases associated with a constitutive activation of type I interferon signaling.The elucidation of the genetic causes of this group of diseases revealed an alteration of nucleic acid processing and signaling.ADAR1 is among the genes found mutated in patients with this type of ...
Frassinelli L. +3 more
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WIREs RNA, 2011
AbstractRNA editing is a term used for a number of mechanistically different processes that alter the nucleotide sequence of RNA molecules to differ from the gene sequence. RNA editing occurs in a wide variety of organisms and is particularly frequent in organelle transcripts of eukaryotes.
Chateigner Boutin, Anne Laure +1 more
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AbstractRNA editing is a term used for a number of mechanistically different processes that alter the nucleotide sequence of RNA molecules to differ from the gene sequence. RNA editing occurs in a wide variety of organisms and is particularly frequent in organelle transcripts of eukaryotes.
Chateigner Boutin, Anne Laure +1 more
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On the evolution of RNA editing
Trends in Genetics, 1993The term 'RNA editing' encompasses a variety of processes that change the primary nucleotide sequence of an RNA transcript from that of its encoding DNA. As in the case of certain other molecular genetic phenomena, for example RNA splicing, the discovery of RNA editing presented molecular biologists with an evolutionary puzzle, since the existence of ...
Michael W. Gray, Patrick S. Covello
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Partially edited RNAs are intermediates of RNA editing in plant mitochondria
The Plant Journal, 2006SummaryRNA editing in flowering plant mitochondria addresses several hundred specific C nucleotides in individual sequence contexts in mRNAs and tRNAs. Many of the in vivo steady state RNAs are edited at some sites but not at others. It is still unclear whether such incompletely edited RNAs can either be completed or are aborted.
Daniil Verbitskiy +4 more
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Journal of Plant Biochemistry and Biotechnology, 2013 Here, we raised some concerns about the identification of RNA editing sites at transcriptomic level which might be interfered by widespread SNPs (single nucleotide polymorphisms) at genomic level. This commentary will remind the RNA biologists that the potential RNA editing sites discovered by high-throughput RNA sequencing without supportive evidences
Xiaoxia Ma, Chaogang Shao, Yijun Meng
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Current Opinion in Cell Biology, 1991
Since its discovery, RNA editing in kinetoplastid mitochondria has proven a fascinating topic of study, and the last one and a half years have witnessed enormous advances in our understanding of this unprecedented form of RNA processing. The information flow in this RNA editing, once considered a candidate for defying the central dogma, is now known to
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Since its discovery, RNA editing in kinetoplastid mitochondria has proven a fascinating topic of study, and the last one and a half years have witnessed enormous advances in our understanding of this unprecedented form of RNA processing. The information flow in this RNA editing, once considered a candidate for defying the central dogma, is now known to
openaire +2 more sources
Physiologia Plantarum, 1994
Higher plant mitochondrial RNAs undergo predetermined modifications which involve differences of splicing and trimming of the primary transcripts. These post‐transcriptional modifications are specific C‐to‐U changes occurring mostly in the coding regions of mRNAs without changing the reading frame.
Simon Litvak +2 more
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Higher plant mitochondrial RNAs undergo predetermined modifications which involve differences of splicing and trimming of the primary transcripts. These post‐transcriptional modifications are specific C‐to‐U changes occurring mostly in the coding regions of mRNAs without changing the reading frame.
Simon Litvak +2 more
openaire +2 more sources
Databases for RNA Editing Collections
2021A-to-I RNA editing in humans plays a relevant role since it can influence gene expression and increase proteome diversity. In addition, its deregulation has been linked to a variety of human diseases, including neurological disorders and cancer.In the last decade, massive transcriptome sequencing through the RNAseq technology has dramatically improved ...
Ernesto Picardi +4 more
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