Results 351 to 360 of about 2,153,086 (396)

RNA editing: getting U into RNA

Trends in Biochemical Sciences, 1997
RNA editing in kinetoplastid protozoa remodels the sequences of mitochondrial pre-mRNAs by the precise insertion and deletion of uridylate residues. These sequence changes are directed by small trans-acting RNAs, termed guide RNAs. The basic mechanistic pathway by which edited RNA is generated has recently been elucidated using in vitro systems capable
Stefan Heidmann, Kenneth Stuart, Kenneth Stuart, Moffett L. Kable, Moffett L. Kable   +4 more
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RNA‐Editing 1999 [PDF]

Biologie in unserer Zeit, 1999
AbstractIn den letzten Jahren wurden immer mehr RNA‐Editingprozesse entdeckt, welche die Abfolge der Nukleotidbausteine einer RNA nach der Abschrift aus dem zugehörigen Gen variieren. Mit der modifizierten Sequenz der Nukleotide ändert sich natürlich auch der Informationsgehalt der RNA ‐ eine Proteinsequenz ist damit in diesen Fällen nicht mehr ...
Axel Brennicke, Volker Knoop
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RNA editing in trypanosomes

European Journal of Biochemistry, 1994
The nucleotide sequence of mitochondrial pre‐mRNAs in trypanosomes is posttranscriptionally edited by the insertion and deletion of uridylate (U) residues. In some RNAs editing is limited to small sections but in African trypanosomes, such as Trypanosoma brucei, 9 of the 18 known mitochondrial mRNAs are created by massive editing which can produce more
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RNA Editing In Trypanosomatid Mitochondria

Annual Review of Microbiology, 1991
INTRODUCTION 327 kDNA 328 Ma.ti circle s .... 329 Mi nicircle s . . ..... . . . . . . . ......... . . .. . . . . . . . . . . . .. . .. . . ... . . . . . . . .. . . . . . . . ...... . . . . . . 329 kDNA Mutati o ns . . .. ... . .... . . .. . .. . .. . . .. . . . . .. . .. ... . . . . ... ..... . .. .. . . . . . . . . . . . . .. .. . . . . .
openaire   +3 more sources

Engineered circular ADAR-recruiting RNAs increase the efficiency and fidelity of RNA editing in vitro and in vivo

Nature Biotechnology, 2022
Zongyi Yi, Liang Qu, Huixian Tang, Zhiheng Liu, Y. Liu, Feng Tian, Chunhui Wang, Xiaoxue Zhang, Ziqi Feng, Ying Yu, Pengfei Yuan, Zexuan Yi, Yanxia Zhao, Wensheng Wei   +13 more
semanticscholar   +1 more source

Endogenous ADAR-mediated RNA editing in non-human primates using stereopure chemically modified oligonucleotides

Nature Biotechnology, 2022
Prashant Monian, C. Shivalila, Genliang Lu, M. Shimizu, D. Boulay, K. Bussow, M. Byrne, Adam Bezigian, Arindom Chatterjee, David Chew, J. Desai, Frank G. Favaloro, Jack Godfrey, Andrew Hoss, N. Iwamoto, T. Kawamoto, Jayakanthan Kumarasamy, A. Lamattina, Amber Lindsey, Fangjun Liu, R. Looby, Subramanian Marappan, Jake Metterville, Ronelle Murphy, Jeff Rossi, Tom Pu, B. Bhattarai, S. Standley, S. Tripathi, Hailin Yang, Yuan Yin, Hui Yu, Cong Zhou, L. Apponi, P. Kandasamy, C. Vargeese   +35 more
semanticscholar   +1 more source

CLUSTER guide RNAs enable precise and efficient RNA editing with endogenous ADAR enzymes in vivo

Nature Biotechnology, 2022
Philipp Reautschnig, Nicolai Wahn, J. Wettengel, A. Schulz, Ngadhnjim Latifi, Paul Vogel, T. Kang, Laura Pfeiffer, C. Zarges, Ulrike Naumann, L. Zender, J. B. Li, Thorsten Stafforst   +12 more
semanticscholar   +1 more source

Visualizing Nuclear RNA Editing

Trends in Biochemical Sciences, 2017
RNA editing results in the site-specific conversion of adenosine to inosine in mRNAs. Genomics has revealed millions of editing sites in metazoans, but examining the spatial aspects of editing in cells has been challenging. A new method, inosineFISH (inoFISH), provides the ability to detect edited and unedited mRNAs within intact cells.
Hodaya Hochberg, Yaron Shav-Tal
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RNA Editing Uridylyltransferases of Trypanosomatids

2007
Terminal RNA uridylyltransferases (TUTases) catalyze the transfer of UMP residues to the 3' hydroxyl group of RNA. These enzymes belong to the DNA polymerase beta superfamily, which also includes poly(A) polymerases, CCA-adding enzymes, and other nucleotidyltransferases.
Ruslan Aphasizhev, Inna Aphasizheva
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Proteome Diversification by RNA Editing

2020
RNA editing is an RNA modification that alters the RNA sequence relative to its genomic blueprint. The most common type of RNA editing is A-to-I editing by double-stranded RNA-specific adenosine deaminase (ADAR) enzymes. Editing of a protein-coding region within the RNA molecule may result in non-synonymous substitutions, leading to a modified protein ...
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