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Physiologia Plantarum, 1994
Higher plant mitochondrial RNAs undergo predetermined modifications which involve differences of splicing and trimming of the primary transcripts. These post‐transcriptional modifications are specific C‐to‐U changes occurring mostly in the coding regions of mRNAs without changing the reading frame.
Simon Litvak +2 more
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Higher plant mitochondrial RNAs undergo predetermined modifications which involve differences of splicing and trimming of the primary transcripts. These post‐transcriptional modifications are specific C‐to‐U changes occurring mostly in the coding regions of mRNAs without changing the reading frame.
Simon Litvak +2 more
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Databases for RNA Editing Collections
2021A-to-I RNA editing in humans plays a relevant role since it can influence gene expression and increase proteome diversity. In addition, its deregulation has been linked to a variety of human diseases, including neurological disorders and cancer.In the last decade, massive transcriptome sequencing through the RNAseq technology has dramatically improved ...
Ernesto Picardi +4 more
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RNA editing: getting U into RNA
Trends in Biochemical Sciences, 1997RNA editing in kinetoplastid protozoa remodels the sequences of mitochondrial pre-mRNAs by the precise insertion and deletion of uridylate residues. These sequence changes are directed by small trans-acting RNAs, termed guide RNAs. The basic mechanistic pathway by which edited RNA is generated has recently been elucidated using in vitro systems capable
Stefan Heidmann +4 more
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European Journal of Biochemistry, 1994
The nucleotide sequence of mitochondrial pre‐mRNAs in trypanosomes is posttranscriptionally edited by the insertion and deletion of uridylate (U) residues. In some RNAs editing is limited to small sections but in African trypanosomes, such as Trypanosoma brucei, 9 of the 18 known mitochondrial mRNAs are created by massive editing which can produce more
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The nucleotide sequence of mitochondrial pre‐mRNAs in trypanosomes is posttranscriptionally edited by the insertion and deletion of uridylate (U) residues. In some RNAs editing is limited to small sections but in African trypanosomes, such as Trypanosoma brucei, 9 of the 18 known mitochondrial mRNAs are created by massive editing which can produce more
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Biologie in unserer Zeit, 1999 AbstractIn den letzten Jahren wurden immer mehr RNA‐Editingprozesse entdeckt, welche die Abfolge der Nukleotidbausteine einer RNA nach der Abschrift aus dem zugehörigen Gen variieren. Mit der modifizierten Sequenz der Nukleotide ändert sich natürlich auch der Informationsgehalt der RNA ‐ eine Proteinsequenz ist damit in diesen Fällen nicht mehr ...
Axel Brennicke, Volker Knoop
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RNA Editing In Trypanosomatid Mitochondria
Annual Review of Microbiology, 1991INTRODUCTION 327 kDNA 328 Ma.ti circle s .... 329 Mi nicircle s . . ..... . . . . . . . ......... . . .. . . . . . . . . . . . .. . .. . . ... . . . . . . . .. . . . . . . . ...... . . . . . . 329 kDNA Mutati o ns . . .. ... . .... . . .. . .. . .. . . .. . . . . .. . .. ... . . . . ... ..... . .. .. . . . . . . . . . . . . .. .. . . . . .
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CLUSTER guide RNAs enable precise and efficient RNA editing with endogenous ADAR enzymes in vivo
Nature Biotechnology, 2022Philipp Reautschnig +12 more
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Visualizing Nuclear RNA Editing
Trends in Biochemical Sciences, 2017RNA editing results in the site-specific conversion of adenosine to inosine in mRNAs. Genomics has revealed millions of editing sites in metazoans, but examining the spatial aspects of editing in cells has been challenging. A new method, inosineFISH (inoFISH), provides the ability to detect edited and unedited mRNAs within intact cells.
Hodaya Hochberg, Yaron Shav-Tal
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