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Current Opinion in Cell Biology, 1991
Since its discovery, RNA editing in kinetoplastid mitochondria has proven a fascinating topic of study, and the last one and a half years have witnessed enormous advances in our understanding of this unprecedented form of RNA processing. The information flow in this RNA editing, once considered a candidate for defying the central dogma, is now known to
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Since its discovery, RNA editing in kinetoplastid mitochondria has proven a fascinating topic of study, and the last one and a half years have witnessed enormous advances in our understanding of this unprecedented form of RNA processing. The information flow in this RNA editing, once considered a candidate for defying the central dogma, is now known to
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Here, we raised some concerns about the identification of RNA editing sites at transcriptomic level which might be interfered by widespread SNPs (single nucleotide polymorphisms) at genomic level. This commentary will remind the RNA biologists that the potential RNA editing sites discovered by high-throughput RNA sequencing without supportive evidences
Xiaoxia Ma, Chaogang Shao, Yijun Meng
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Physiologia Plantarum, 1994
Higher plant mitochondrial RNAs undergo predetermined modifications which involve differences of splicing and trimming of the primary transcripts. These post‐transcriptional modifications are specific C‐to‐U changes occurring mostly in the coding regions of mRNAs without changing the reading frame.
Simon Litvak+2 more
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Higher plant mitochondrial RNAs undergo predetermined modifications which involve differences of splicing and trimming of the primary transcripts. These post‐transcriptional modifications are specific C‐to‐U changes occurring mostly in the coding regions of mRNAs without changing the reading frame.
Simon Litvak+2 more
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Databases for RNA Editing Collections
2021A-to-I RNA editing in humans plays a relevant role since it can influence gene expression and increase proteome diversity. In addition, its deregulation has been linked to a variety of human diseases, including neurological disorders and cancer.In the last decade, massive transcriptome sequencing through the RNAseq technology has dramatically improved ...
Ernesto Picardi+4 more
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RNA editing: getting U into RNA
Trends in Biochemical Sciences, 1997RNA editing in kinetoplastid protozoa remodels the sequences of mitochondrial pre-mRNAs by the precise insertion and deletion of uridylate residues. These sequence changes are directed by small trans-acting RNAs, termed guide RNAs. The basic mechanistic pathway by which edited RNA is generated has recently been elucidated using in vitro systems capable
Stefan Heidmann+4 more
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AbstractIn den letzten Jahren wurden immer mehr RNA‐Editingprozesse entdeckt, welche die Abfolge der Nukleotidbausteine einer RNA nach der Abschrift aus dem zugehörigen Gen variieren. Mit der modifizierten Sequenz der Nukleotide ändert sich natürlich auch der Informationsgehalt der RNA ‐ eine Proteinsequenz ist damit in diesen Fällen nicht mehr ...
Axel Brennicke, Volker Knoop
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European Journal of Biochemistry, 1994
The nucleotide sequence of mitochondrial pre‐mRNAs in trypanosomes is posttranscriptionally edited by the insertion and deletion of uridylate (U) residues. In some RNAs editing is limited to small sections but in African trypanosomes, such as Trypanosoma brucei, 9 of the 18 known mitochondrial mRNAs are created by massive editing which can produce more
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The nucleotide sequence of mitochondrial pre‐mRNAs in trypanosomes is posttranscriptionally edited by the insertion and deletion of uridylate (U) residues. In some RNAs editing is limited to small sections but in African trypanosomes, such as Trypanosoma brucei, 9 of the 18 known mitochondrial mRNAs are created by massive editing which can produce more
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RNA Editing In Trypanosomatid Mitochondria
Annual Review of Microbiology, 1991INTRODUCTION 327 kDNA 328 Ma.ti circle s .... 329 Mi nicircle s . . ..... . . . . . . . ......... . . .. . . . . . . . . . . . .. . .. . . ... . . . . . . . .. . . . . . . . ...... . . . . . . 329 kDNA Mutati o ns . . .. ... . .... . . .. . .. . .. . . .. . . . . .. . .. ... . . . . ... ..... . .. .. . . . . . . . . . . . . .. .. . . . . .
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